Light-driven photosensitizer uptake increases Candida albicans photodynamic inactivation

2017 ◽  
Vol 10 (11) ◽  
pp. 1538-1546 ◽  
Author(s):  
Renan A. Romano ◽  
Sebastião Pratavieira ◽  
Ana P. da Silva ◽  
Cristina Kurachi ◽  
Francisco E. G. Guimarães
Keyword(s):  
Candida Albicans ◽  
Photodynamic Inactivation

scholarly journals Antimicrobial Photodynamic Inactivation Inhibits Candida albicans Virulence Factors and ReducesIn VivoPathogenicity

2012 ◽  
Vol 57 (1) ◽  
pp. 445-451 ◽  
Author(s):  
Ilka Tiemy Kato ◽  
Renato Araujo Prates ◽  
Caetano Padial Sabino ◽  
Beth Burgwyn Fuchs ◽  
George P. Tegos ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Virulence Factors ◽  
Sodium Dodecyl ◽  
Systemic Infection ◽  
Tube Formation ◽  
Photodynamic Inactivation ◽  
Content Type ◽  
Daughter Cells

ABSTRACTThe objective of this study was to evaluate whetherCandida albicansexhibits altered pathogenicity characteristics following sublethal antimicrobial photodynamic inactivation (APDI) and if such alterations are maintained in the daughter cells.C. albicanswas exposed to sublethal APDI by using methylene blue (MB) as a photosensitizer (0.05 mM) combined with a GaAlAs diode laser (λ 660 nm, 75 mW/cm2, 9 to 27 J/cm2).In vitro, we evaluated APDI effects onC. albicansgrowth, germ tube formation, sensitivity to oxidative and osmotic stress, cell wall integrity, and fluconazole susceptibility.In vivo, we evaluatedC. albicanspathogenicity with a mouse model of systemic infection. Animal survival was evaluated daily. Sublethal MB-mediated APDI reduced the growth rate and the ability ofC. albicansto form germ tubes compared to untreated cells (P< 0.05). Survival of mice systemically infected withC. albicanspretreated with APDI was significantly increased compared to mice infected with untreated yeast (P< 0.05). APDI increasedC. albicanssensitivity to sodium dodecyl sulfate, caffeine, and hydrogen peroxide. The MIC for fluconazole forC. albicanswas also reduced following sublethal MB-mediated APDI. However, none of those pathogenic parameters was altered in daughter cells ofC. albicanssubmitted to APDI. These data suggest that APDI may inhibit virulence factors and reducein vivopathogenicity ofC. albicans. The absence of alterations in daughter cells indicates that APDI effects are transitory. The MIC reduction for fluconazole following APDI suggests that this antifungal could be combined with APDI to treatC. albicansinfections.

scholarly journals Comparative Study on the Efficiency of the Photodynamic Inactivation of Candida albicans Using CdTe Quantum Dots, Zn(II) Porphyrin and Their Conjugates as Photosensitizers

Molecules ◽  
2015 ◽  
Vol 20 (5) ◽  
pp. 8893-8912 ◽  
Author(s):  
Osnir Viana ◽  
Martha Ribeiro ◽  
Andréa Rodas ◽  
Júlio Rebouças ◽  
Adriana Fontes ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Candida Albicans ◽  
Comparative Study ◽  
Cdte Quantum Dots ◽  
Photodynamic Inactivation

Photodynamic inactivation of Candida albicans mediated by a low density of light energy

2013 ◽  
Author(s):  
Gabriel Salles Barbério ◽  
Soraia Veloso da Costa ◽  
Mariana dos Santos Silva ◽  
Thaís Marchini de Oliveira ◽  
Thiago Cruvinel Silva ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Light Energy ◽  
Low Density ◽  
Photodynamic Inactivation

Biofilms of Candida albicans and Streptococcus sanguinis and their susceptibility to antimicrobial effects of photodynamic inactivation

2018 ◽  
Vol 24 ◽  
pp. 95-101 ◽  
Author(s):  
Ana Luiza do Rosário Palma ◽  
Lucas de Paula-Ramos ◽  
Nádia Domingues ◽  
Graziella Nuernberg Back-Brito ◽  
Luciane Dias de Oliveira ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Inactivation ◽  
Streptococcus Sanguinis ◽  
Antimicrobial Effects

scholarly journals Photodynamic inactivation in the expression of the Candida albicans genes ALS3, HWP1, BCR1, TEC1, CPH1, and EFG1 in biofilms

2018 ◽  
Vol 33 (7) ◽  
pp. 1447-1454 ◽  
Author(s):  
Fernanda Freire ◽  
Patrícia Pimentel de Barros ◽  
Cristiane Aparecida Pereira ◽  
Juliana Campos Junqueira ◽  
Antonio Olavo Cardoso Jorge
Keyword(s):  
Candida Albicans ◽  
Photodynamic Inactivation

scholarly journals Antimicrobial photodynamic inactivation of fungal biofilm using amino functionalized mesoporus silica-rose bengal nanoconjugate against Candida albicans

2018 ◽  
Vol 1 ◽  
pp. e00007 ◽  
Author(s):  
Parasuraman Paramanantham ◽  
Asha P Antony ◽  
S.B. Sruthil Lal ◽  
Alok Sharan ◽  
Asad Syed ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Rose Bengal ◽  
Photodynamic Inactivation

Photodynamic inactivation of chlorin e6-loaded CTAB-liposomes against Candida albicans

2013 ◽  
Vol 45 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Yu-Tsai Yang ◽  
Hsiung-Fei Chien ◽  
Po-Han Chang ◽  
Yee-Chun Chen ◽  
Michael Jay ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Chlorin E6 ◽  
Photodynamic Inactivation

Evaluation of gene expression SAP5, LIP9, and PLB2 of Candida albicans biofilms after photodynamic inactivation

2015 ◽  
Vol 30 (5) ◽  
pp. 1511-1518 ◽  
Author(s):  
Fernanda Freire ◽  
Patrícia Pimentel de Barros ◽  
Damara da Silva Ávila ◽  
Graziella Nuernberg Back Brito ◽  
Juliana Campos Junqueira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Candida Albicans ◽  
Photodynamic Inactivation ◽  
Candida Albicans Biofilms

Mechanistic aspects of the photodynamic inactivation of Candida albicans induced by cationic porphyrin derivatives

2012 ◽  
Vol 58 ◽  
pp. 332-339 ◽  
Author(s):  
Ezequiel D. Quiroga ◽  
M. Paula Cormick ◽  
Patricia Pons ◽  
M. Gabriela Alvarez ◽  
Edgardo N. Durantini
Keyword(s):  
Candida Albicans ◽  
Photodynamic Inactivation ◽  
Cationic Porphyrin ◽  
Porphyrin Derivatives
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