In vivo and in situ imaging of controlled-release dissolving silk microneedles into the skin by optical coherence tomography

2016 ◽  
Vol 10 (6-7) ◽  
pp. 870-877 ◽  
Author(s):  
Ran Liu ◽  
Mingtian Zhang ◽  
Cuiyun Jin
Keyword(s):  
Optical Coherence Tomography ◽  
Controlled Release ◽  
Optical Coherence ◽  
In Situ Imaging

In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography

2010 ◽  
Vol 28 (1) ◽  
pp. 66-81 ◽  
Author(s):  
Siôn A. Coulman ◽  
James C. Birchall ◽  
Aneesh Alex ◽  
Marc Pearton ◽  
Bernd Hofer ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Human Volunteers ◽  
In Situ Imaging

In vivo in situ en face optical coherence tomography imaging of chick embryos

2009 ◽  
Author(s):  
Michael Leitner ◽  
Joana Castanheira ◽  
Luís Ferreira ◽  
Mónica Ferreira ◽  
Isabel Palmeirim ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Chick Embryos ◽  
Optical Coherence ◽  
Tomography Imaging ◽  
En Face ◽  
Optical Coherence Tomography Imaging

scholarly journals Biomolecular Contrast Agents for Optical Coherence Tomography

2019 ◽  
Author(s):  
George J. Lu ◽  
Li-dek Chou ◽  
Dina Malounda ◽  
Amit K. Patel ◽  
Derek S. Welsbie ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Contrast Agents ◽  
Fluorescent Protein ◽  
Mouse Retina ◽  
Optical Coherence ◽  
Gas Vesicles ◽  
Cellular Functions ◽  
Green Fluorescent

ABSTRACTOptical coherence tomography (OCT) has gained wide adoption in biological and medical imaging due to its exceptional tissue penetration, 3D imaging speed and rich contrast. However, OCT plays a relatively small role in molecular and cellular imaging due to the lack of suitable biomolecular contrast agents. In particular, while the green fluorescent protein has provided revolutionary capabilities to fluorescence microscopy by connecting it to cellular functions such as gene expression, no equivalent reporter gene is currently available for OCT. Here we introduce gas vesicles, a unique class of naturally evolved gas-filled protein nanostructures, as the first genetically encodable OCT contrast agents. The differential refractive index of their gas compartments relative to surrounding aqueous tissue and their nanoscale motion enables gas vesicles to be detected by static and dynamic OCT at picomolar concentrations. Furthermore, the OCT contrast of gas vesicles can be selectively erasedin situwith ultrasound, allowing unambiguous assignment of their location. In addition, gas vesicle clustering modulates their temporal signal, enabling the design of dynamic biosensors. We demonstrate the use of gas vesicles as reporter genes in bacterial colonies and as purified contrast agentsin vivoin the mouse retina. Our results expand the utility of OCT as a unique photonic modality to image a wider variety of cellular and molecular processes.

Quantitative in situ imaging and grading of oral precancer with attenuation corrected-optical coherence tomography

Oral Oncology ◽  
2021 ◽  
pp. 105216
Author(s):  
Biswajoy Ghosh ◽  
Avishek Bhandari ◽  
Mousumi Mandal ◽  
Ranjan Rashmi Paul ◽  
Mousumi Pal ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Oral Precancer ◽  
Attenuation Corrected ◽  
In Situ Imaging

scholarly journals In situ imaging of lung alveoli with an optical coherence tomography needle probe

2011 ◽  
Vol 16 (3) ◽  
pp. 036009 ◽  
Author(s):  
Bryden C. Quirk ◽  
Robert A. McLaughlin ◽  
Andrea Curatolo ◽  
Rodney W. Kirk ◽  
Peter B. Noble ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Needle Probe ◽  
In Situ Imaging
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