Diagnosis of liver cancer from blood sera using FTIR microspectroscopy: a preliminary study

2014 ◽  
Vol 7 (3-4) ◽  
pp. 222-231 ◽  
Author(s):  
Kanjana Thumanu ◽  
Suleeporn Sangrajrang ◽  
Thiravud Khuhaprema ◽  
Anant Kalalak ◽  
Waraporn Tanthanuch ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Ftir Microspectroscopy ◽  
Preliminary Study

scholarly journals Dissecting the biological diversity of hepatocellular carcinoma: Opening Pandora's Box

2016 ◽  
Vol 2 (4) ◽  
pp. 179
Author(s):  
Omar Abdel-Rahman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cell Lines ◽  
Biological Diversity ◽  
Primary Liver Cancer ◽  
Low Grade ◽  
High Grade ◽  
B Virus ◽  
Preliminary Study ◽  
To Come

<p>Primary liver cancer is one of the most commonly occur-ring malignancies, albeit one with a deadly consequence as it ranks second in males and sixth in females as a cause of cancer-related death [1, 2]. In this regard, hepatocellular carcinoma (HCC) constitutes almost 90% of confirmed primary liver cancer cases [3]. Despite the advances in clinical classifications of HCC according to patient-related and disease-related criteria (e.g., the Barcelona Clinic liver cancer system) [4], exploring the biological diversity of HCC have lagged behind. The biological diversity of HCC is ex-pected to come from a diverse set of etiological factors (Hepatitis-B virus, Hepatitis-C virus, non-alcoholic stea-tohepatitis, and aflatoxin, among other things), all of which are expected to drive the pathogenesis of HCC via various pathways. In the current issue of AMOR, Youssef and co-workers explored the potential involvement of the cofactor of BRCA1 (COBRA1) in HCC pathogenesis [5]. COBRA1 has been incriminated in the pathogenesis of a number of other solid tumors, notably breast cancer. In the current study, the authors investigated the expression of COBRA1 in several HCC cell lines, ranging from low- to high-grade HCC cell lines. Their results showed that the COBRA1 protein was highly expressed in the low-grade HCC cell line, while significantly down-regulated in high-grade HCC cell lines. This preliminary study indicates that COBRA1 may indeed play a role in HCC pathogenesis and progression, and should be further investigated moving forward.</p><p>Primary liver cancer is one of the most commonly occurring malignancies, albeit one with a deadly consequence as it ranks second in males and sixth in females as a cause of cancer-related death [1,2]. In this regard, hepatocellular carcinoma (HCC) constitutes almost 90% of confirmed primary liver cancer cases [3].</p><p>Despite the advances in clinical classifications of HCC according to patient-related and disease-related criteria (<em>e.g.</em>, the Barcelona Clinic liver cancer system) [4], exploring the biological diversity of HCC have lagged behind. The biological diversity of HCC is expected to come from a diverse set of etiological factors (Hepatitis-B virus, Hepatitis-C virus, non-alcoholic steatohepatitis, and aflatoxin, among other things), all of which are expected to drive the pathogenesis of HCC via various pathways.</p><p>In the current issue of AMOR, Youssef and co-workers explored the potential involvement of the cofactor of BRCA1 (COBRA1) in HCC pathogenesis [5].  COBRA1 has been incriminated in the pathogenesis of a number of other solid tumors, notably breast cancer. In the current study, the authors investigated the expression of COBRA1 in several HCC cell lines, ranging from low- to high-grade HCC cell lines. Their results showed that the COBRA1 protein was highly expressed in the low-grade HCC cell line, while significantly down-regu- lated in high-grade HCC cell lines. This preliminary study indicates that COBRA1 may indeed play a role in HCC pathogenesis and progression, and should be further investigated moving forward.</p>

FTIR microspectroscopy of melanocytic skin lesions: a preliminary study

The Analyst ◽  
2010 ◽  
Vol 135 (12) ◽  
pp. 3213 ◽  
Author(s):  
Giorgio Tosi ◽  
Carla Conti ◽  
Elisabetta Giorgini ◽  
Paolo Ferraris ◽  
Maria Grazia Garavaglia ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Ftir Microspectroscopy ◽  
Preliminary Study

Observations of liver cancer cells in scanning probe acoustic microscope: a preliminary study

2016 ◽  
Author(s):  
Xiaohui Chen ◽  
Xiaoyue Fang ◽  
Qing Xi ◽  
Hua Guo ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Scanning Probe ◽  
Acoustic Microscope ◽  
Liver Cancer Cells ◽  
Preliminary Study

Establishment of a Cancer Registry in Senegal: Preliminary results

2021 ◽  
Vol 1 (1) ◽  
pp. 15-16
Author(s):  
Salif Baldé ◽  
O Ba ◽  
Mamadou Diop ◽  
G Diouf ◽  
T Fall ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Liver Cancer ◽  
Cancer Registry ◽  
Palliative Treatment ◽  
Main Mode ◽  
Preliminary Results ◽  
Common Location ◽  
The Media ◽  
Preliminary Study

INTRODUCTION: Senegal with the support of WHO has undertaken the establishment of a National Cancer Registry. The objective of this work was to assess the preliminary results. MATERIALS AND METHODS: We conducted a non-exhaustive preliminary study over a period of three months from January 1, 2013 to March 31, 2013 at four hospitals in Dakar. RESULTS: Two hundred and eighty-nine cases were identified. These were 127 men (44%) and 126 women (56%) with a sex-ratio of 0.8. The ages ranged from 20 to 90 with an average of 50. The main mode of diagnosis was essentially histological with 76% of cases (n=219). The most frequent locations were ENT (25%), hepatic (7%) and bronchopulmonary (4.5%). In men, liver cancer was the most common location and in women cervical cancer with 16%. Squamous cell carcinoma was the most frequent histological type with 68% of cases followed by adenocarcinoma with 22% of cases. Thirty-eight percent of the patients were classified as stage III and IV. A quarter of our patients have received palliative treatment. In contrast, 15 (15%) received chemotherapy and 4% radiotherapy. Data collection was satisfactory. CONCLUSION: Cancer is a reality in Senegal but it remains underdiagnosed. The media allow the cancer registry to be made effective across the country.

scholarly journals A preliminary study on the optical diagnosis of sclerosing osteomyelitis of the mandible using FTIR microspectroscopy

2001 ◽  
Vol 41 (supplement) ◽  
pp. S92
Author(s):  
T. Ogawa ◽  
N. Miyoshi ◽  
H. Hidenobu ◽  
T. Yamada ◽  
T. Toshiyuki ◽  
...  
Keyword(s):  
Optical Diagnosis ◽  
Ftir Microspectroscopy ◽  
Preliminary Study

The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

1967 ◽  
Vol 25 ◽  
pp. 180-181
Author(s):  
John H.L. Watson ◽  
John L. Swedo ◽  
R.W. Talley
Keyword(s):  
Mammary Carcinoma ◽  
Osmium Tetroxide ◽  
Estrogen Therapy ◽  
Ultrastructural Level ◽  
Uranyl Acetate ◽  
Human Mammary Carcinoma ◽  
Surgical Biopsy ◽  
Lead Hydroxide ◽  
Preliminary Study ◽  
Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

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