Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride

2003 ◽  
Vol 23 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Pablo Muriel ◽  
Yesenia Escobar
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Kupffer Cells

EFFECTS OF NATURAL AND RECOMBINANT INTERFERON ON CARBON TETRACHLORIDE- INDUCED LIVER CIRRHOSIS

2001 ◽  
Vol 10 (2) ◽  
pp. 11-17
Author(s):  
Mohamed Hassan ◽  
Mona El-Azab ◽  
EI-Sayed El-Awady ◽  
Soad Abou-El-Ela
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Recombinant Interferon

Pharmacodynamic Changes of Mivacurium in Liver Cirrhosis Model in Rabbits Using Carbon Tetrachloride Intoxication

2004 ◽  
Vol 46 (6) ◽  
pp. 708
Author(s):  
Young Duk Cha ◽  
Hong Sik Lee ◽  
Hwa Young Ki ◽  
Hye Jin Park ◽  
Chun Woo Yang ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Carbon Tetrachloride Intoxication

Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis

1997 ◽  
Vol 273 (1) ◽  
pp. G124-G130 ◽  
Author(s):  
D. C. Rockey ◽  
J. J. Chung
Keyword(s):  
Nitric Oxide ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Kupffer Cells ◽  
Hepatic Injury ◽  
Bile Duct Ligation ◽  
Inos Mrna ◽  
No Production ◽  
Nonparenchymal Cells ◽  
Duct Ligation

Nitric oxide (NO) production via inducible NO synthase (iNOS) is prominent in the liver after stimulation with cytokines and/or lipopolysaccharide. The aim of this study was to investigate the production of NO via iNOS in specific liver cell populations during toxin-mediated and obstructive hepatic injury and fibrogenesis. After a single dose of carbon tetrachloride, iNOS mRNA and nitrite (a metabolic product of NO) were detected only in Kupffer cells. They were not detectable in any cell type after recurrent administration of carbon tetrachloride, including in animals with far advanced cirrhosis (i.e., portal hypertension and/or ascites). After bile duct ligation, a mechanistically different form of liver injury and fibrogenesis, iNOS mRNA and nitrite were identified in all nonparenchymal cells but not in hepatocytes. Twenty-four hours after bile duct ligation, iNOS mRNA and NO production were greatest in Kupffer cells, but after prolonged bile duct ligation, iNOS was found predominantly in sinusoidal endothelial cells. These data indicate that iNOS expression varies temporally and spatially in the liver after injury and also varies with the type of insult.

Nanoparticle Based Delivery of Quercetin for the Treatment of Carbon Tetrachloride Mediated Liver Cirrhosis in Rats

2016 ◽  
Vol 12 (2) ◽  
pp. 274-285 ◽  
Author(s):  
Shashi Kant Verma ◽  
Shweta Rastogi ◽  
Indu Arora ◽  
Kalim Javed ◽  
Mohd Akhtar ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride

scholarly journals Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

2012 ◽  
Vol 27 (8) ◽  
pp. 589-594 ◽  
Author(s):  
Thamirys Guimarães Marques ◽  
Eleazar Chaib ◽  
Juliana Hamati da Fonseca ◽  
Ana Cecília Rodrigues Lourenço ◽  
Felipe Duarte Silva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Web Sites ◽  
Bile Duct Ligation ◽  
Experimental Models ◽  
Duct Ligation ◽  
Experimental Liver Cirrhosis ◽  
Experimental Liver ◽  
Better Than

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

scholarly journals Oral Supplementation with Branched-Chain Amino Acids Improves Transthyretin Turnover in Rats with Carbon Tetrachloride-Induced Liver Cirrhosis

1996 ◽  
Vol 126 (5) ◽  
pp. 1412-1420 ◽  
Author(s):  
Toshio Usui ◽  
Hisataka Moriwaki ◽  
Hiroo Hatakeyama ◽  
Tetsuhiro Kasai ◽  
Masahiko Kato ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Branched Chain Amino Acids ◽  
Oral Supplementation ◽  
Branched Chain

Depressed sensitivity of the hepatoportal NaCl receptors in rats with carbon tetrachloride-induced liver cirrhosis

1995 ◽  
Vol 269 (6) ◽  
pp. R1390-R1395 ◽  
Author(s):  
K. Tanaka ◽  
T. Matsuda ◽  
H. Morita ◽  
H. Hosomi
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Present Article ◽  
Treatment Period ◽  
Liver Tissue ◽  
Afferent Nerves ◽  
Significant Difference ◽  
Norepinephrine Content ◽  
Ccl4 Treatment ◽  
Tissue Norepinephrine

In normal rats, the activity of the hepatoportal NaCl-sensitive afferent nerves is increased by portal injection of hypertonic NaCl. In the present article, we have found this effect to be markedly reduced in rats with CCl4-induced liver cirrhosis (CT rats). Liver tissue norepinephrine content, a marker of tissue innervation, was also decreased in the treated rats. Over the 12 wk CCl4-treatment period, no significant difference in Na balance was found between control and CT rats when both groups were given normal NaCl (0.45%) food. However, when both were given high NaCl (8%) food, the Na balance of CT rats was positive and greater than that of controls. These results indicate that the sensitivity of the hepatoportal NaCl receptors is decreased even when the degree of liver cirrhosis is slight. This mechanism plays an important role in maintaining Na balance during intake of high NaCl food.

107 Transplantation of endothelial progenitor cells improves carbon tetrachloride (CCL4)-induced liver cirrhosis in rats

2006 ◽  
Vol 44 ◽  
pp. S46-S47
Author(s):  
T. Nakamura ◽  
T. Torimura ◽  
M. Sakamoto ◽  
E. Taniguchi ◽  
O. Hashimoto ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor
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