Efficacy of soap and water‐based skin decontamination using in vitro animal models: A systematic review

2021 ◽  
Author(s):  
Maxwell Green ◽  
Nadia Kashetsky ◽  
Aileen M. Feschuk ◽  
Howard I. Maibach
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Water Based ◽  
Skin Decontamination

Transplantation of Adipose-derived Cells for Periodontal Regeneration: A Systematic Review

2019 ◽  
Vol 14 (6) ◽  
pp. 504-518 ◽  
Author(s):  
Dilcele Silva Moreira Dziedzic ◽  
Bassam Felipe Mogharbel ◽  
Priscila Elias Ferreira ◽  
Ana Carolina Irioda ◽  
Katherine Athayde Teixeira de Carvalho
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
In Vitro Studies ◽  
In Vivo Studies ◽  
Cell Sources ◽  
Study Designs

This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords “ADIPOSE”, “CELLS”, and “PERIODONTAL”, with the Boolean operator “AND”. A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose- derived cells stimulate neovascularization, have osteogenic and odontogenic potential; besides adhesion, proliferation and differentiation on probable cell carriers. Preclinical studies described improvement of bone and periodontal healing with the association of adipose-derived cells and the carrier materials tested: Platelet Rich Plasma, Fibrin, Collagen and Synthetic polymer. There is evidence from the current in vitro and in vivo data indicating that adipose-derived cells may contribute to bone and periodontal regeneration. The small quantity of studies and the large variation on study designs, from animal models, cell sources and defect morphology, did not favor a meta-analysis. Additional studies need to be conducted to investigate the regeneration variability and the mechanisms of cell participation in the processes. An overview of animal models, cell sources, and scaffolds, as well as new perspectives are provided for future bone and periodontal regeneration study designs.

scholarly journals Anticancer Effects of Disulfiram: A Systematic Review of in Vitro, Animal, and Human Studies

2021 ◽  
Author(s):  
ling wang ◽  
yang yu ◽  
cong zhou ◽  
run wan ◽  
Yumin Li
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Animal Models ◽  
Human Studies ◽  
Cochrane Library ◽  
Future Research ◽  
Tumor Inhibition ◽  
Anti Tumor Activity

Abstract Background and objectives: Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Several preclinical and clinical studies have examined the potential of repurposing disulfiram (DSF) as an anticancer treatment. This systematic review aimed to assess evidence regarding the antineoplastic activity of DSF in in vitro and in vivo models, as well as in humans.Methods: Two authors independently conducted this systematic review of English and Chinese articles from the PubMed, Embase, and the Cochrane Library databases up to July 2019. Eligible in vitro studies needed to include assessments of the apoptosis rate by flow cytometry using annexin V/propidium iodide, and studies in animal models and clinical trials needed to examine tumor inhibition rates, and progression-free survival (PFS) and overall survival (OS), respectively. Data were analyzed using descriptive statistics.Results: Overall, 35 studies, i.e., 21 performed in vitro, 11 based on animal models, and three clinical trials, were finally included. In vitro and animal studies indicated that DSF was associated with enhanced apoptosis and tumor inhibition rates. Human studies showed that DSF prolongs PFS and OS. The greatest anti-tumor activity was observed when DSF was used as combination therapy or as a nanoparticle-encapsulated molecule.Conclusions: This systematic review provides evidence regarding the anti-tumor activity of DSF in vitro, in animals, and in humans and indicates the optimal forms of treatment to be evaluated in future research.

scholarly journals Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2532
Author(s):  
Ludovica Bartiromo ◽  
Matteo Schimberni ◽  
Roberta Villanacci ◽  
Jessica Ottolina ◽  
Carolina Dolci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Cultured Cells ◽  
Regulatory Pathways ◽  
Medical Databases ◽  
Lesion Growth ◽  
Experimental Findings

The aim of this systematic review was to provide comprehensive and available data on the possible role of phytoestrogens (PE) for the treatment of endometriosis. We conducted an advanced, systematic search of online medical databases PubMed and Medline. Only full-length manuscripts written in English up to September 2020 were considered. A total of 60 studies were included in the systematic review. According to in vitro findings, 19 out of 22 studies reported the ability of PE in inducing anti-proliferative, anti-inflammatory and proapoptotic effects on cultured cells. Various mechanisms have been proposed to explain this in vitro action including the alteration of cell cycle proteins, the activation/inactivation of regulatory pathways, and modification of radical oxidative species levels. Thirty-eight articles on the effects of phytoestrogens on the development of endometriotic lesions in in vivo experimental animal models of endometriosis have been included. In line with in vitro findings, results also derived from animal models of endometriosis generally supported a beneficial effect of the compounds in reducing lesion growth and development. Finally, only seven studies investigated the effects of phytoestrogens intake on endometriosis in humans. The huge amount of in vitro and in vivo animal findings did not correspond to a consistent literature in the women affected. Therefore, whether the experimental findings can be translated in women is currently unknown.

scholarly journals Sex Specific Determinants in Osteoarthritis: A Systematic Review of Preclinical Studies

2020 ◽  
Vol 21 (10) ◽  
pp. 3696 ◽  
Author(s):  
Deyanira Contartese ◽  
Matilde Tschon ◽  
Monica De Mattei ◽  
Milena Fini
Keyword(s):  
Gene Expression ◽  
Systematic Review ◽  
Sex Differences ◽  
Animal Models ◽  
Molecular Mechanisms ◽  
Joint Disease ◽  
In Vivo Studies ◽  
Preclinical Studies

Osteoarthritis (OA) is a highly prevalent joint disease that primarily affects about 10% of the world’s population over 60 years old. The purpose of this study is to systematically review the preclinical studies regarding sex differences in OA, with particular attention to the molecular aspect and gene expression, but also to the histopathological aspects. Three databases (PubMed, Scopus, and Web of Knowledge) were screened for eligible studies. In vitro and in vivo papers written in English, published in the last 11 years (2009–2020) were eligible. Participants were preclinical studies, including cell cultures and animal models of OA, evaluating sex differences. Independent extraction of articles and quality assessments were performed by two authors using predefined data fields and specific tools (Animals in Research Reporting In Vivo Experiments (ARRIVE) guideline and Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool). Twenty-three studies were included in the review: 4 in vitro studies, 18 in vivo studies, and 1 both in vitro and in vivo study. From in vitro works, sex differences were found in the gene expression of inflammatory molecules, hormonal receptors, and in responsiveness to hormonal stimulation. In vivo research showed a great heterogeneity of animal models mainly focused on the histopathological aspects rather than on the analysis of sex-related molecular mechanisms. This review highlights that many gaps in knowledge still exist; improvementsin the selection and reporting of animal models, the use of advanced in vitro models, and multiomics analyses might contribute to developing a personalized gender-based medicine.

scholarly journals Optimal therapeutic adropin dose intervention in mice and rat animal models: A systematic review

2021 ◽  
pp. 1426-1429
Author(s):  
Foad Alzoughool ◽  
Mohammad Borhan Al-Zghoul
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Glucose Homeostasis ◽  
Energy Homeostasis ◽  
Daily Injection ◽  
Optimum Dose ◽  
Therapeutic Effects ◽  
Factors Affecting ◽  
Study Results

Background and Aim: Adropin is a hormone encoded by the Enho gene, which is associated with energy homeostasis. Preclinical studies using animal models have shown that adropin plays a role in enhancing glucose homeostasis and dyslipidemia. Lately, several studies on animal models have been performed to examine the therapeutic and pathophysiological effects of adropin in many disorders. The aim of this systematic review was to identify the ideal adropin dose in mice and rat animal models. Materials and Methods: We systematically searched PubMed, Science Direct, and Scopus databases from 2008 to 2020. The terms used in the search were "adropin," "adropin doses in animal models," "glucose homeostasis related to adropin," and "adropin therapeutic effects on rats and mice." Articles that included non-adropin doses, in vitro studies, and factors affecting adropin levels were excluded from the study. Results: Of the total 179 qualified studies, six studies were included. We found that a daily injection of 450 nmol/kg of adropin for 3 days might be considered the optimum dose of effect in mice, whereas injection of 2.1 μg/kg once a day for 10 successive days might be the optimal effective dose in rats. Conclusion: Additional investigations are needed to determine the optimum dose of adropin to be used as a therapeutic intervention depending on the animal model.

scholarly journals Septopremaxillary ligament traction system: a review

2019 ◽  
Vol 6 (4) ◽  
pp. 1363
Author(s):  
Rajani R. Elayadath ◽  
Biswas P. Palakunnu
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Animal Studies ◽  
Experimental Models ◽  
Human Condition ◽  
System A ◽  
Biomechanical Force ◽  
Traction System

Over the years, several animal studies have been conducted concerning the role of cartilaginous nasal septum, septopremaxillary ligament in midfacial growth. Most of the studies utilized non primate animal models at first and then more recently in primates such as chimpanzee. Proper choice of animal model to extrapolate from is critical for successful experimental design. Although nonhuman primates are phylogenetically closer to humans than other mammalian groups for better extrapolation to human condition, not all the craniofacial experiments require primate models. Renewed interests in understanding the influence of septopremaxillary ligament resection on midfacial growth led to many in vitro experiments on animal models. Recently systematic review of relevant animal experiment is regarded as a prerequisite for the conduct of the new clinical trials. Despite this fact, the literature addressing this topic in humans and systematic review on the effect of the septopremaxillary ligament is scarce. The more recent studies show that the maxillary labial frenum encloses the septopremaxillary ligament and forms an important constituent of septopremaxillary traction system. The biomechanical force mediating through the septopremaxillary ligament, maxillary labial frenum and nasolabial muscles results in stimulating their effects on sagital growth of the maxilla. The main purpose of this review is to update and extend the knowledge of the role of septopremaxillary traction system on the midfacial growth by synthesizing the available literature involving the septopremaxillary ligament resection in experimental models. If this review could synthesize the results of relevant research, a change in the therapeutic notions can also be expected.

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