Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets

2021 ◽  
Author(s):  
Leila Ghiasvand Mohammadkhani ◽  
Maryam Khoshkam ◽  
Mohsen Kompany‐Zareh ◽  
Mahdi Amiri ◽  
Ali Ramazani
Keyword(s):  
Graphene Oxide ◽  
Graphene Oxide Nanosheets ◽  
In Vivo Toxicity

scholarly journals Graphene oxide nanosheets modulate spinal glutamatergic transmission and modify locomotor behaviour in an in vivo zebrafish model

2020 ◽  
Vol 5 (8) ◽  
pp. 1250-1263
Author(s):  
Giada Cellot ◽  
Sandra Vranic ◽  
Yuyoung Shin ◽  
Robyn Worsley ◽  
Artur Filipe Rodrigues ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Glutamatergic Transmission ◽  
Graphene Oxide Nanosheets ◽  
Zebrafish Model ◽  
Locomotor Behaviour

The article reports that graphene oxide nanosheets (s-GO), by interfering with synapses, have the potential to be used as behavioural modulators.

scholarly journals Polydopamine-doped virus-like mesoporous silica coated reduced graphene oxide nanosheets for chemo-photothermal synergetic therapy

2020 ◽  
Vol 35 (1) ◽  
pp. 28-38
Author(s):  
Jieying Liao ◽  
Huicong Zhang ◽  
Xuandong Wang
Keyword(s):  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Reduced Graphene Oxide ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Graphene Oxide Nanosheets ◽  
Stratification Method ◽  
Reduced Graphene ◽  
Post Modification

Multifunctional nanocarriers have been widely accepted and utilized for biomedical applications, because of their structural regularity, convenient post-modification and controllable structure and morphology. Herein, we reported polydopamine-doped virus-like mesoporous silica coated reduced graphene oxide nanosheets (rGO@PVMSNs) nanocomposites by a facile oil–water biphase stratification method. The synthesized rGO@PVMSNs nanocomposites performed excellent biocompatibility and photothermal performance. They could be employed as photoacoustic imaging contrast in vivo. Furthermore, the rGO@PVMSNs nanocarriers were used for loading the antitumor drug doxorubicin (DOX), the rGO@PVMSNs@DOX nanocomposites were also demonstrated to be with high inhibition of HepG2 cancer cells, especially with the help of near-infrared irradiation, which were more efficient than single chemotherapy or photothermal therapy. The rGO@PVMSNs@DOX nanocomposites of this work could be used as photoacoustic imaging and chemo-photothermal synergetic therapy agents, which show a new perspective for clinical tumor diagnosis and therapy.

Magnetite/dextran-functionalized graphene oxide nanosheets for in vivo positive contrast magnetic resonance imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (59) ◽  
pp. 47529-47537 ◽  
Author(s):  
S. Moradi ◽  
O. Akhavan ◽  
A. Tayyebi ◽  
R. Rahighi ◽  
M. Mohammadzadeh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Graphene Oxide ◽  
Positive Contrast ◽  
Functionalized Graphene ◽  
Resonance Imaging ◽  
Graphene Oxide Nanosheets ◽  
Functionalized Graphene Oxide ◽  
Contrast Magnetic Resonance ◽  
The Right

In vivo positive contrast MRI by magnetite/dextran-functionalized graphene oxide (SPIO-Dex-FGO) as compared to Magnevist® (the right rat).

Graphene oxide nanosheets induce DNA damage and activate the base excision repair (BER) signaling pathway both in vitro and in vivo

Chemosphere ◽  
2017 ◽  
Vol 184 ◽  
pp. 795-805 ◽  
Author(s):  
Chun-Jiao Lu ◽  
Xue-Feng Jiang ◽  
Muhammad Junaid ◽  
Yan-Bo Ma ◽  
Pan-Pan Jia ◽  
...  
Keyword(s):  
Dna Damage ◽  
Graphene Oxide ◽  
Signaling Pathway ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Graphene Oxide Nanosheets ◽  
Base Excision

Investigations on the in-vivo toxicity analysis of reduced graphene oxide/TiO2 nanocomposite in zebrafish embryo and larvae (Danio rerio)

2019 ◽  
Vol 481 ◽  
pp. 1360-1369 ◽  
Author(s):  
J. Prakash ◽  
Manigandan Venkatesan ◽  
Joy Sebastian Prakash J ◽  
G. Bharath ◽  
Shoaib Anwer ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Danio Rerio ◽  
Zebrafish Embryo ◽  
In Vivo Toxicity ◽  
Reduced Graphene ◽  
Toxicity Analysis

scholarly journals Graphene Oxide Nanosheets Target Excitatory Synapses in the Hippocampus: Reversible Down Regulation of Glutamate Neurotransmission In-Vivo

2018 ◽  
Vol 114 (3) ◽  
pp. 672a
Author(s):  
Rossana Rauti ◽  
Manuela Medelin ◽  
Neus Lozano ◽  
Denis Scaini ◽  
Kostas Kostarelos ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Excitatory Synapses ◽  
Graphene Oxide Nanosheets ◽  
Down Regulation ◽  
Glutamate Neurotransmission
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