Acute and subacute toxicity evaluation of Houttuynia cordata ethanol extract and plasma metabolic profiling analysis in both male and female rats

2021 ◽  
Author(s):  
Hongjiang Chen ◽  
Xiuxiu Sha ◽  
Yiyuan Luo ◽  
Jianwei Chen ◽  
Xiang Li ◽  
...  
Keyword(s):  
Metabolic Profiling ◽  
Ethanol Extract ◽  
Female Rats ◽  
Toxicity Evaluation ◽  
Houttuynia Cordata ◽  
Male And Female ◽  
Subacute Toxicity ◽  
Male And Female Rats ◽  
Metabolic Profiling Analysis ◽  
Profiling Analysis

A 13-week repeated oral dose toxicity evaluation and a 4-week recovery evaluation of the Sam So Eum (SSE) in male and female rats

2020 ◽  
Vol 260 ◽  
pp. 112988 ◽  
Author(s):  
Jong-Hyun Nho ◽  
Hyun-Joo Lee ◽  
Seon-Yu Lee ◽  
Ji-Hun Jang ◽  
Beo-Deul Yang ◽  
...  
Keyword(s):  
Oral Dose ◽  
Female Rats ◽  
Toxicity Evaluation ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Acute and subacute toxicity assessment of an aqueous extract of Crotalaria retusa (Fabaceae) in Swiss mice and Wistar rats

2021 ◽  
Vol 11 (6) ◽  
pp. 94-100
Author(s):  
Lane Adrien GOH BI ◽  
Noel Kouame TOTO ◽  
Ouga Stanislas ZAHOUI ◽  
Yomalan KASSI ◽  
Semi Anthelme NENE Bi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Aqueous Extract ◽  
Wistar Rat ◽  
Toxicity Assessment ◽  
Female Rats ◽  
Male And Female ◽  
Subacute Toxicity ◽  
Swiss Mice ◽  
Aerial Parts ◽  
Male And Female Rats

The present study is a contribution to the enhancement of Ivorian traditional medicine, by carrying out bio-tolerance tests of an aqueous extract of the aerial parts of Crotalaria retusa (EACr) in mice and rats according to the guidelines of the Organization for Economic Co-operation and Development (OECD) 423 and 407, respectively. The doses of 2000 and 5000 mg/kg of body weight (BW) of the extract were used for acute toxicity. For subacute toxicity which lasted 28 days, doses of 500, 1000, and 2000 mg/kg BW have been used. The administration of the single doses of 2000 and 5000 mg/kg BW of EACr did not provoke death in female mice in the acute toxicity setting. For subacute toxicity in rats (male and female), the administration of repetitive doses of 500, 1000, and 2000 mg/kg BW of EACr over a period of 28 days did not cause death in these animals. In females, these doses caused weight loss and a decrease in platelets. The extract reduced the activity of AST in both sexes of rats. The findings also showed that this extract would possess a nephroprotective property in male and female rats. Keywords: Crotalaria retusa, Acute and subacute toxicities, Wistar rat, Swiss mice

THE PITUITARY AND ADRENAL RESPONSES TO ADMINISTRATION OF OESTRIOL IN GONADECTOMIZED RATS

1961 ◽  
Vol 38 (1) ◽  
pp. 50-58 ◽  
Author(s):  
N. E. Borglin ◽  
L. Bjersing
Keyword(s):  
Pituitary Gland ◽  
Adrenal Cortex ◽  
Clinical Experience ◽  
Uterine Cervix ◽  
Morphological Changes ◽  
Physiological Significance ◽  
Female Rats ◽  
Experimental Conditions ◽  
Male And Female ◽  
Male And Female Rats

ABSTRACT Oestriol (oestra-1,3,5(10)-triene-3,16α,17β-triol) is a weakly oestrogenic substance which, however, in contrast to what was formerly believed, is of physiological significance. Its effect is localized largely to the uterine cervix and vagina. Clinical experience argues both for and against an effect on the pituitary gland. This investigation is concerned with the morphological changes in the pituitary gland and adrenal cortex of gonadectomized male and female rats after the injection of oestriol. It was found that oestriol has the same type of action on these glands as other oestrogens, but under the experimental conditions used, this effect proved much weaker than that produced by oestradiol (oestra-1,3,5(10)-triene-3,17β-diol).

INDUCTION OF GOITRE BY PTU OR KClO4 IN MALE AND FEMALE RATS. EFFECT OF GONADECTOMY

1973 ◽  
Vol 74 (1) ◽  
pp. 88-104 ◽  
Author(s):  
T. Jolín ◽  
M. J. Tarin ◽  
M. D. Garcia
Keyword(s):  
Iodine Content ◽  
High Plasma ◽  
Disc Electrophoresis ◽  
Female Rats ◽  
Male Rats ◽  
Adult Rats ◽  
Male And Female ◽  
Glucose Levels ◽  
Male And Female Rats ◽  
Tsh Levels

ABSTRACT Male and female rats of varying ages were placad on a low iodine diet (LID) plus KClO4 or 6-propyl-2-thiouracil (PTU) or on the same diet supplemented with I (control rats). Goitrogenesis was also induced with LID plus PTU in gonadectomized animals of both sexes. The weight of the control and goitrogen treated animals, and the weight and iodine content of their thyroids were determined, as well as the plasma PBI, TSH, insulin and glucose levels. The pituitary GH-like protein content was assessed by disc electrophoresis on polyacrylamide gels. If goitrogenesis was induced in young rats of both sexes starting with rats of the same age, body weight (B.W.) and pituitary growth hormone (GH) content, it was found that both the males and females developed goitres of the same size. On the contrary, when goitrogenesis was induced in adult animals, it was found that male rats, that had larger B.W. and pituitary GH content than age-paired females, developed larger goitres. However, both male and female rats were in a hypothyroid condition of comparable degree as judged by the thyroidal iodine content and the plasma PBI and TSH levels. When all the data on the PTU or KClO4-treated male and female rats of varying age and B.W. were considered together, it was observed that the weights of the thyroids increased proportionally to B.W. However, a difference in the slope of the regression of the thyroid weight over B.W. was found between male and female rats, due to the fact that adult male rats develop larger goitres than female animals. In addition, in the male rats treated with PTU, gonadectomy decreased the B.W., pituitary content of GH-like protein and, concomitantly, the size of the goitre decreased; an opposite effect was induced by ovariectomy on the female animals. However, when goitrogenesis was induced in weight-paired adult rats of both sexes, the male animals still developed larger goitres than the females. Among all the parameters studied here, the only ones which appeared to bear a consistent relationship with the size of the goitres in rats of different sexes, treated with a given goitrogen, were the rate of body growth and the amount of a pituitary GH-like protein found before the onset of the goitrogen treatment. Moreover, though the pituitary content of the GH-like protein decreased as a consequence of goitrogen treatment, it was still somewhat higher in male that in female animals. The present results suggest that GH may somehow be involved in the mechanism by which male and female rats on goitrogens develop goitres of different sizes, despite equally high plasma TSH levels.

GONADOTROPHIN PATTERNS IN MALE AND FEMALE RATS:

1968 ◽  
Vol 58 (4) ◽  
pp. 600-612 ◽  
Author(s):  
Robert Boyd ◽  
Donald C. Johnson
Keyword(s):  
Ascorbic Acid ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Female Rat ◽  
Feedback Effects ◽  
Male And Female ◽  
Prostate Weight ◽  
Male And Female Rats ◽  
Males And Females ◽  
Normal Males

ABSTRACT The effects of various doses of testosterone propionate (TP) upon the release of luteinizing hormone (LH or ICSH) from the hypophysis of a gonadectomized male or female rat were compared. Prostate weight in hypophysectomized male parabiotic partners was used to evaluate the quantity of circulating LH. Hypophyseal LH was measured by the ovarian ascorbic acid depletion method. Males castrated when 45 days old secreted significantly more LH and had three times the amount of pituitary LH as ovariectomized females. Administration of 25 μg TP daily reduced the amount of LH in the plasma, and increased the amount in the pituitary gland, in both sexes. Treatment with 50 μg caused a further reduction in plasma LH in males, but not in females, while pituitary levels in both were equal to that of their respective controls. LH fell to the same low level in partners of males or females receiving 100 μg TP. When gonadectomized at 39 days, males and females had the same amount of plasma LH, but males had more stored hormone. Pituitary levels were unchanged from controls following treatment with 12.5, 25 or 50 μg TP daily, but plasma values dropped an equal amount in both sexes with the latter two doses. Androgenized males or females, gonadectomized when 39 days old, were very sensitive to the effects of TP and plasma LH was significantly reduced with 12.5 μg daily. Pituitary LH in androgenized males was higher than that of normal males but was reduced to normal by small amounts of TP. The amount of stored LH in androgenized females was not different from that of normal females and it was unchanged by any dose of TP tested. Results are consistent with the conclusion that the male hypothalamic-hypophyseal axis is at least as sensitive as the female axis to the negative feedback effects of TP. Androgenization increases the sensitivity to TP in both males and females.

Studies on progestin binding sites in the hepatic microsomal fraction of male and female rats

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S191-S192
Author(s):  
M. STOPPOK ◽  
H. SCHRIEFERS ◽  
E. R. LAX
Keyword(s):  
Binding Sites ◽  
Microsomal Fraction ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats
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