scholarly journals Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE −/− mouse model

2021 ◽  
Author(s):  
Ulrike Kogel ◽  
Ee Tsin Wong ◽  
Justyna Szostak ◽  
Wei Teck Tan ◽  
Francesco Lucci ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Inhalation Exposure ◽  
Smoke Exposure ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Exposure Study ◽  
Apoe Mouse

scholarly journals Cigarette exposure induces changes in maternal vascular function in a pregnant mouse model

2010 ◽  
Vol 298 (5) ◽  
pp. R1249-R1256 ◽  
Author(s):  
Robin E. Gandley ◽  
Arun Jeyabalan ◽  
Ketaki Desai ◽  
Stacy McGonigal ◽  
Jennifer Rohland ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Smoke Exposure ◽  
Renal Arteries ◽  
Growth Restriction ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Pregnant Mice

Smoking is associated with multiple adverse pregnancy outcomes, including fetal growth restriction. The objective of this study was to determine whether cigarette smoke exposure during pregnancy in a mouse model affects the functional properties of maternal uterine, mesenteric, and renal arteries as a possible mechanism for growth restriction. C57Bl/CJ mice were exposed to whole body sidestream smoke for 4 h/day. Smoke particle exposure was increased from day 4 of gestation until late pregnancy ( day 16–19), with mean total suspended particle levels of 63 mg/m3, representative of moderate-to-heavy smoking in humans. Uterine, mesenteric, and renal arteries from late-pregnant and virgin mice were isolated and studied in a pressure-arteriograph system ( n = 23). Plasma cotinine was measured by ELISA. Fetal weights were significantly reduced in smoke-exposed compared with control fetuses (0.88 ± 0.1 vs. 1.0 ± 0.08 g, P < 0.02), while litter sizes were not different. Endothelium-mediated relaxation responses to methacholine were significantly impaired in both the uterine and mesenteric vasculature of pregnant mice exposed to cigarette smoke during gestation. This difference was not apparent in isolated renal arteries from pregnant mice exposed to cigarette smoke; however, relaxation was significantly reduced in renal arteries from smoke-exposed virgin mice. In conclusion, we found that passive cigarette smoke exposure is associated with impaired vascular relaxation of uterine and mesenteric arteries in pregnant mice. Functional maternal vascular perturbations during pregnancy, specifically impaired peripheral and uterine vasodilation, may contribute to a mechanism by which smoking results in fetal growth restriction.

Comparison of the immune response in a mouse model of whole body and nose-only cigarette smoke-exposure

2017 ◽  
Author(s):  
Jef Serré ◽  
Tom Tanjeko Ajimé ◽  
Carolien Mathyssen ◽  
Tobias Heigl ◽  
Karen Maes ◽  
...  
Keyword(s):  
Immune Response ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Whole Body ◽  
Cigarette Smoke Exposure

scholarly journals Prenatal cigarette smoke exposure slightly alters neurobehavioral development in neonatal rats: Implications for developmental origins of health and disease (DoHAD)

2020 ◽  
Vol 107 (1) ◽  
pp. 55-66
Author(s):  
B. Mammel ◽  
T. Kvárik ◽  
Zs. Szabó ◽  
J. Gyarmati ◽  
T. Ertl ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Motor Coordination ◽  
Smoke Exposure ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Control Group ◽  
Developmental Origins ◽  
Smoking During Pregnancy ◽  
Neurobehavioral Development ◽  
Health And Disease

AbstractNumerous studies indicate that smoking during pregnancy exerts harmful effects on fetal brain development. The aim of this study was to determine the influence of maternal smoking during pregnancy on the early physical and neurobehavioral development of newborn rats. Wistar rats were subjected to whole-body smoke exposure for 2 × 40 min daily from the day of mating until day of delivery. For this treatment, a manual closed-chamber smoking system and 4 research cigarettes per occasion were used. After delivery the offspring were tested daily for somatic growth, maturation of facial characteristics and neurobehavioral development until three weeks of age. Motor coordination tests were performed at 3 and 4 weeks of age. We found that prenatal cigarette smoke exposure did not alter weight gain or motor coordination. Critical physical reflexes indicative of neurobehavioral development (eyelid reflex, ear unfolding) appeared significantly later in pups prenatally exposed to smoke as compared to the control group. Prenatal smoke exposure also resulted in a delayed appearance of reflexes indicating neural maturity, including hind limb grasping and forelimb placing reflexes. In conclusion, clinically relevant prenatal exposure to cigarette smoke results in slightly altered neurobehavioral development in rat pups. These findings suggest that chronic exposure of pregnant mothers to cigarette smoke (including passive smoking) results in persisting alterations in the developing brain, which may have long-lasting consequences supporting the concept of developmental origins of health and disease (DoHAD).

scholarly journals Chronic Cigarette Smoke Exposure Primes NK Cell Activation in a Mouse Model of Chronic Obstructive Pulmonary Disease

2010 ◽  
Vol 184 (8) ◽  
pp. 4460-4469 ◽  
Author(s):  
Gregory T. Motz ◽  
Bryan L. Eppert ◽  
Brian W. Wortham ◽  
Robyn M. Amos-Kroohs ◽  
Jennifer L. Flury ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Mouse Model ◽  
Pulmonary Disease ◽  
Cigarette Smoke ◽  
Cell Activation ◽  
Nk Cell ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Long-Term Cigarette Smoke Exposure in a Mouse Model of Ciliated Epithelial Cell Function

2010 ◽  
Vol 43 (6) ◽  
pp. 635-640 ◽  
Author(s):  
Samantha M. Simet ◽  
Joseph H. Sisson ◽  
Jacqueline A. Pavlik ◽  
Jane M. DeVasure ◽  
Craig Boyer ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Cell Function ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Ciliated Epithelial Cell

scholarly journals Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

10.3791/61793 ◽  
2020 ◽  
Author(s):  
Daniel E. Morales-Mantilla ◽  
Xinyan Huang ◽  
Philip Erice ◽  
Paul Porter ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Whole Body Inhalation

Cigarette Smoke Exposure Triggers Autophagy-Mediated Ovarian Follicle Loss in a Mouse Model.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 37-37
Author(s):  
Anne Marie Gannon ◽  
Martin Stampfli ◽  
Warren G. Foster
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Ovarian Follicle ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

scholarly journals Comparison and evaluation of two different methods to establish the cigarette smoke exposure mouse model of COPD

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jiaze Shu ◽  
Defu Li ◽  
Haiping Ouyang ◽  
Junyi Huang ◽  
Zhen Long ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure
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