Relationship between osteoid formation and iron deposition induced by chronic cadmium exposure in ovariectomized rats

2020 ◽  
Author(s):  
Yumi Wako ◽  
Hideaki Hiratsuka ◽  
Tetsurou Kurotaki ◽  
Minoru Tsuchitani ◽  
Takashi Umemura
Keyword(s):  
Cadmium Exposure ◽  
Iron Deposition ◽  
Ovariectomized Rats ◽  
Osteoid Formation

Iron Deposition at Mineralization Fronts and Osteoid Formation Following Chronic Cadmium Exposure in Ovariectomized Rats

1997 ◽  
Vol 143 (2) ◽  
pp. 348-356 ◽  
Author(s):  
Hideaki Hiratsuka ◽  
Osamu Katsuta ◽  
Naoto Toyota ◽  
Minoru Tsuchitani ◽  
Takashi Akiba ◽  
...  
Keyword(s):  
Cadmium Exposure ◽  
Iron Deposition ◽  
Ovariectomized Rats ◽  
Osteoid Formation

P18: Relationship between osteoid formations and iron deposition induced by chronic cadmium exposure in ovariectomized rats

2009 ◽  
Vol 61 (4) ◽  
pp. 410-411
Author(s):  
Yumi Wako ◽  
Hideaki Hiratsuka ◽  
Yoshimasa Kurata ◽  
Minoru Tsuchitani ◽  
Takashi Umemura
Keyword(s):  
Cadmium Exposure ◽  
Iron Deposition ◽  
Ovariectomized Rats

Uncoupling between Bone Formation and Resorption in Ovariectomized Rats with Chronic Cadmium Exposure

2000 ◽  
Vol 164 (3) ◽  
pp. 264-272 ◽  
Author(s):  
Kohei Uriu ◽  
Isao Morimoto ◽  
Keiko Kai ◽  
Yuichi Okazaki ◽  
Yusuke Okada ◽  
...  
Keyword(s):  
Bone Formation ◽  
Cadmium Exposure ◽  
Ovariectomized Rats

Chronic Cadmium Exposure-Induced Renal Anemia in Ovariectomized Rats

1996 ◽  
Vol 137 (2) ◽  
pp. 228-236 ◽  
Author(s):  
Hideaki Hiratsuka ◽  
Osamu Katsuta ◽  
Naoto Toyota ◽  
Minoru Tsuchitani ◽  
Takashi Umemura ◽  
...  
Keyword(s):  
Cadmium Exposure ◽  
Renal Anemia ◽  
Ovariectomized Rats

Estrogenic effects of pomegranate extracts in ovariectomized rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
W Promprom ◽  
W Lijuan ◽  
P Munglue ◽  
P Kupittayanant ◽  
K Indrapichate ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Estrogenic Effects

Anti-osteoporotic effect of Eucommia ulmoides cortex in ovariectomized rats

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
B Kim ◽  
DW Lim ◽  
J Song ◽  
H Kim
Keyword(s):  
Ovariectomized Rats ◽  
Eucommia Ulmoides

Iron status in diabetes mellitus

2019 ◽  
pp. 7-12
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cells ◽  
Defense Mechanism ◽  
Acute Stress ◽  
Islet Cells ◽  
Iron Status ◽  
Acute Phase Reactant ◽  
Iron Deposition ◽  
Muscle Tissues ◽  
High Production

Diabetes mellitus can be defined as chronic metabolic disease which results from either relative or complete absence of insulin by the pancreatic beta islet cells. This in-turn may lead to hyperglycemia due to disturbances in the metabolism of glucose. In the human body, iron is con- sidered to be an effective pro-oxidant and participates in the generation of reactive oxygen species (ROS) such as hydroxyl radical. Because of the poor antioxidant defense mechanism of beta cells (low production of antioxidant enzymes such as catalase, glutathione peroxidase and dismutase), so they are highly prone to iron-induced oxidative stress and iron deposition in it and this will lead to apoptosis, and subsequently insulin deficiency. This iron deposition in beta cells will also lead to insulin resistance by reducing insulin extracting ability of the liver and inhibiting glucose uptake in muscle tissues and fats, this in turn will result in high production of hepatic glucose. Ferritin which is an acute phase reactant protein, that responds to acute stress like trauma, infections, tissue necrosis and surgery, it can produce diabetes mellitus either through inflammation or by increasing iron stores.

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