Protective effects of S ‐carvedilol on doxorubicin‐induced damages to human umbilical vein endothelial cells and rats

2019 ◽  
Vol 39 (8) ◽  
pp. 1233-1244 ◽  
Author(s):  
Ting Wu ◽  
Haixin Li ◽  
Qunsheng Lan ◽  
Ze‐an Zhao ◽  
Ying Cao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

scholarly journals Protective effects of hyperoside against H2O2-induced apoptosis in human umbilical vein endothelial cells

2016 ◽  
Vol 14 (1) ◽  
pp. 399-405 ◽  
Author(s):  
XU-LIANG HAO ◽  
YA KANG ◽  
JIAN-KUAN LI ◽  
QING-SHAN LI ◽  
EN-LI LIU ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Human Umbilical Vein ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

scholarly journals The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells

2019 ◽  
Vol 8 (6) ◽  
pp. 1050-1056
Author(s):  
Zahra Karimi ◽  
Maryam Ghaffari ◽  
Jafar Ezzati Nazhad Dolatabadi ◽  
Parvin Dehghan
Keyword(s):  
Endothelial Cells ◽  
Protective Effect ◽  
Food Industry ◽  
Umbilical Vein ◽  
Protective Agent ◽  
Protective Effects ◽  
Oxidative Rancidity ◽  
Dapi Staining ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Abstract 2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry. However, this antioxidant can stimulate cytotoxicity in human umbilical vein endothelial cells (HUVECs). Thus, potential protective effects of thymoquinone (TQ) against TBHQ-induced cytotoxicity were investigated. Cytotoxicity was evaluated via MTT, flow cytometry, DAPI staining and DNA fragmentation methods. The obtained results revealed that treatment of HUVECs with TQ enhanced the cell viability rate and it had potential to reduce the cytotoxicity effect of TBHQ in cells. Also, in a combined regime of TQ and TBHQ, apoptosis was reduced compared to the cells treated with TBHQ (p < 0.05). Similarly, TQ had a protective effect on DNA and chromatin fragmentation of the cells treated with TBHQ. Finally, it can be concluded that TQ could be used as a protective agent against cytotoxicity induced by TBHQ in HUVECs.

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