Estrogenic effects of fluorinated diiodine alkanes in MCF‐7 cells, H295R cells and zebrafish embryo assays

2019 ◽  
Vol 39 (7) ◽  
pp. 945-954 ◽  
Author(s):  
Liang Lu ◽  
Jia Chang ◽  
Yunliang Qiu ◽  
Yan Chang ◽  
Jing Ma
Keyword(s):  
Zebrafish Embryo ◽  
Estrogenic Effects ◽  
H295r Cells ◽  
Mcf 7

In vitro toxicological assessment of flumethrin’s effects on MCF-7 breast cancer cells

2021 ◽  
pp. 096032712110227
Author(s):  
S Kara-Ertekin ◽  
S Yazar ◽  
M Erkan
Keyword(s):  
Breast Cancer ◽  
Cancer Cell Line ◽  
Tail Length ◽  
Tail Moment ◽  
High Concentration ◽  
Toxicological Assessment ◽  
Estrogenic Effects ◽  
Pyrethroid Pesticides ◽  
Mcf 7

Pyrethroid pesticides are frequently used for household insect control of insects and in agriculture and livestock. Flumethrin is a pyrethroid that is used against ectoparasites in many animals. The goal of this study was to evaluate the cytotoxic, apoptotic, genotoxic, and estrogenic effects of flumethrin on the mammalian breast cancer cell line (MCF-7). Compared with control groups, a dose-dependent decrease was observed in cell viability at concentrations of 100 µM and higher. The cytotoxic and apoptotic effects detected by LDH assay and AO/EtBr staining increased significantly at a concentration of 1000 µM. The expression of BCL2, which is an anti-apoptotic gene, significantly decreased, whereas BAX, TP53, and P21 expression significantly increased. The results of a comet assay indicated that flumethrin significantly changed tail length, tail % DNA, tail moment, and Olive tail moment in concentrations above 1 and 10 µM. In addition, a 0.1 µM concentration of flumethrin affected ERα receptor mediated cell proliferation and increased transcription of estrogen-responsive pS2 (TFF1) and progesterone receptor (PGR) genes. As a result, flumethrin-induced apoptosis and cytotoxicity at a high concentration, while induced genotoxicity even at lower concentrations. Flumethrin is an endocrine disrupting insecticide with estrogenic effects at very low concentrations.

(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture

2007 ◽  
Vol 221 (3) ◽  
pp. 372-383 ◽  
Author(s):  
J.A. van Meeuwen ◽  
N. Korthagen ◽  
P.C. de Jong ◽  
A.H. Piersma ◽  
M. van den Berg
Keyword(s):  
Estrogenic Effects ◽  
Mcf 7

Nitrogen-containing bisphosphonates may exert potent estrogenic effects on MCF-7 breast cancer cells growth

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 52
Author(s):  
F. Journé ◽  
C. Chaboteaux ◽  
G. Leclercq ◽  
G. Laurent ◽  
J.J. Body
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogenic Effects ◽  
Mcf 7

Estrogenic Effects of Cimicifuga racemosa (Black Cohosh) in Mice and on Estrogen Receptors in MCF-7 Cells

2001 ◽  
Vol 4 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Z.P. Liu ◽  
B. Yu ◽  
J.S. Huo ◽  
C.Q. Lu ◽  
J.S. Chen
Keyword(s):  
Estrogen Receptors ◽  
Black Cohosh ◽  
Cimicifuga Racemosa ◽  
Estrogenic Effects ◽  
Mcf 7

scholarly journals Estrogenic Effects of Extracts and Isolated Compounds from Belowground and Aerial Parts of Spartina anglica

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 210
Author(s):  
Sullim Lee ◽  
Geum Jin Kim ◽  
Hyukbean Kwon ◽  
Joo-Won Nam ◽  
Ji Yun Baek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rat Model ◽  
Estrogenic Activity ◽  
Cancer Development ◽  
Female Rat ◽  
Spartina Anglica ◽  
Immature Female ◽  
Breast Cancer Development ◽  
Estrogenic Effects ◽  
Mcf 7

Menopause, caused by decreases in estrogen production, results in symptoms such as facial flushing, vaginal atrophy, and osteoporosis. Although hormone replacement therapy is utilized to treat menopausal symptoms, it is associated with a risk of breast cancer development. We aimed to evaluate the estrogenic activities of Spartina anglica (SA) and its compounds and identify potential candidates for the treatment of estrogen reduction without the risk of breast cancer. We evaluated the estrogenic and anti-proliferative effects of extracts of SA and its compounds in MCF-7 breast cancer cells. We performed an uterotrophic assay using an immature female rat model. Among extracts of SA, belowground part (SA-bg-E50) had potent estrogenic activity. In the immature female rat model, the administration of SA-bg-E50 increased uterine weight compared with that in the normal group. Among the compounds isolated from SA, 1,3-di-O-trans-feruloyl-(-)-quinic acid (1) had significant estrogenic activity and induced phosphorylation at serine residues of estrogen receptor (ER)α. All extracts and compounds from SA did not increase MCF-7 cell proliferation. Compound 1 is expected to act as an ERα ligand and have estrogenic effects, without side effects, such as breast cancer development.

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