Direct activation of aryl hydrocarbon receptor by benzo[ a ]pyrene elicits T‐helper 2‐driven proinflammatory responses in a mouse model of allergic dermatitis

2019 ◽  
Vol 39 (7) ◽  
pp. 936-944 ◽  
Author(s):  
Hitoshi Tajima ◽  
Risako Tajiki‐Nishino ◽  
Yuko Watanabe ◽  
Tomoki Fukuyama
Keyword(s):  
Mouse Model ◽  
Aryl Hydrocarbon Receptor ◽  
T Helper ◽  
Allergic Dermatitis ◽  
T Helper 2 ◽  
Direct Activation ◽  
Aryl Hydrocarbon ◽  
Proinflammatory Responses

scholarly journals Galactomyces fermentation filtrate prevents T helper 2‐mediated reduction of filaggrin in an aryl hydrocarbon receptor‐dependent manner

2015 ◽  
Vol 40 (7) ◽  
pp. 786-793 ◽  
Author(s):  
K. Takei ◽  
C. Mitoma ◽  
A. Hashimoto‐Hachiya ◽  
M. Takahara ◽  
G. Tsuji ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Dependent Manner ◽  
T Helper ◽  
T Helper 2 ◽  
Aryl Hydrocarbon ◽  
Mediated Reduction

Direct activation of the aryl hydrocarbon receptor by dog allergen participates in airway neutrophilic inflammation

Allergy ◽  
2021 ◽  
Author(s):  
Mélodie Bouté ◽  
Saliha Ait Yahia ◽  
Julie Nanou ◽  
Daniel Alvarez‐Simon ◽  
Camille Audousset ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Neutrophilic Inflammation ◽  
Direct Activation ◽  
Aryl Hydrocarbon ◽  
Dog Allergen

A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen

2018 ◽  
Vol 58 ◽  
pp. 122-130 ◽  
Author(s):  
Hyun Jung Park ◽  
Wahn Soo Choi ◽  
Won Young Lee ◽  
Youngsok Choi ◽  
Chankyu Park ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Model ◽  
T Helper ◽  
T Helper 2

scholarly journals Modulation of T helper 1 and T helper 2 immune balance in a stress mouse model during Chlamydia muridarum genital infection

2019 ◽  
Author(s):  
Tesfaye Belay ◽  
Elisha Martin ◽  
Gezelle Brown ◽  
Raenel Crenshaw ◽  
Julia Street ◽  
...  
Keyword(s):  
Mouse Model ◽  
Genital Infection ◽  
Th2 Cytokines ◽  
T Helper ◽  
T Helper 1 ◽  
Chlamydia Muridarum ◽  
T Helper 2 ◽  
Induced Stress ◽  
Ifn Γ ◽  
Th1 And Th2

ABSTRACTA mouse model to study the effect of cold-induced stress on Chlamydia muridarum genital infection and immune response has been developed in our laboratory. Our previous results show that cold-induced stress increases the intensity of chlamydia genital infection, but little is known about the effect of cold-induced stress on differentiations and activities of T cell subpopulations and bone marrow derived dendritic cells (BMDCs). The factors that regulate the production of T helper 1 (Th1) or T helper 2 (Th2) cytokines is not clear. The objective of this study was to examine whether cold-induced stress modulates the expression of transcription factors and hallmark cytokines of Th1 and Th2 or differentiation of BMDCs during C. muridarum genital infection in mice. Our results show that mRNA level of beta2-adrenergic receptor (β2-AR) compared to β1-AR and β3-AR was high in mixed population of CD4+ T cells and BMDCs. Further, decreased expression of T-bet and low level of interferon-gamma (IFN-γ) production and increased expression of GATA-3 and interleukin-4 (IL-4) production in CD4+ T of stressed mice was observed. Exposure of BMDCs to feroterol (β2-AR agonist) or ICI,118551 (β2-AR antagonist), respectively, revealed significant stimulation or inhibition of β2-AR in stressed mice. Moreover, co-culturing of mature BMDC and naïve CD4+ T cells resulted in increased production of IL-4, IL-10, and IL-17 in culture supernatants, suggesting that stimulation of β2-AR leads to the increased production of Th2 cytokines. Overall, our results show for the first time that cold-induced stress is able to modulate the pattern of Th1 and Th2 cytokine environment, suggesting that it promotes the differentiation to Th2 rather than Th1 by the overexpression of GATA-3 correlated with elevated production of IL-4, IL-10, IL-23, and IL-17 in contrast to a low expression of T-bet correlated with less IFN-γ secretion in the mouse model.

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