Altered thyroid hormone levels affect body condition at metamorphosis in larvae of Xenopus laevis

2018 ◽  
Vol 38 (11) ◽  
pp. 1416-1425 ◽  
Author(s):  
Katharina Ruthsatz ◽  
Kathrin H. Dausmann ◽  
Claudia Drees ◽  
Laura I. Becker ◽  
Lisa Hartmann ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Body Condition ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

STUDIES ON THE ORIGIN OF ALTERED THYROID HORMONE LEVELS IN THE BLOOD OF RATS DURING COLD EXPOSURE

1979 ◽  
Vol 91 (3) ◽  
pp. 484-492 ◽  
Author(s):  
C. van Hardeveld ◽  
M. J. Zuidwijk ◽  
A. A. H. Kassenaar
Keyword(s):  
Thyroid Hormone ◽  
Cold Exposure ◽  
Plasma Levels ◽  
Dose Regimen ◽  
Sympathetic Activity ◽  
Chemical Sympathectomy ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

ABSTRACT The effect of sympathetic activity on T4 and T3 levels in cold-exposed rats was investigated. Administration of the highest dose of propranolol (2 mg/100 g b.w.) twice daily during 4 days decreased T4 and T3 concentrations in plasma of rats living at 23°C (T4 from 46.4 ± 2.6 to 25.8 ± 5.3 nmol/l and T3 from 1.08. ± 0.6 to 0.82 ± 0.12 nmol/l). No significant effect on T4 and T3 levels (49.0 ± 11.6 and 1.48 ± 0.16 n/mol, respectively) after the administration of the same dose regimen of propranolol was observed in rats exposed to cold for 4 weeks. T4 and T3 levels in rats exposed to cold for 4 weeks were not significantly altered 1 week after sympathectomy, while remaining in the cold. However, chemical sympathectomy before cold exposure delayed the cold induced T3 elevation occurring during the first week of cold exposure (controls: from 1.16 ± 0.19 to 1.44 ± 0.29 nmol/l; sympathectomized rats: from 1.07 ± 0.12 to 1.17 ± 0.22 nmol/l). After 2 weeks of cold exposure the T3 levels of controls and sympathectomized rats were not significantly different (controls: 1.45 ± 0.12 nmol/l, sympathectomized rats: 1.38 ± 0.15 nmol/l). No effect of sympathectomy was observed on T4 levels. These experiments show that the role of sympathetic activity in increasing T3 is not clear during cold exposure. They provide some evidence that sympathetic activity may play a role in the initiation of the process leading to increased T3 plasma levels during cold exposure.

Altered thyroid hormone levels in bacterial sepsis: The role of nutritional adequacy

Metabolism ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 936-942 ◽  
Author(s):  
David A. Richmand ◽  
Mark E. Molitch ◽  
Thomas F. O'Donnell
Keyword(s):  
Thyroid Hormone ◽  
Bacterial Sepsis ◽  
Nutritional Adequacy ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

Effect of Altered Thyroid Hormone Levels on Hypothalamic-Pituitary-Adrenal Function*

1987 ◽  
Vol 65 (5) ◽  
pp. 994-999 ◽  
Author(s):  
THEMIS C. KAMILARIS ◽  
C. ROWAN DEBOLD ◽  
SPYROS N. PAVLOU ◽  
DONALD P. ISLAND ◽  
ANESTIS HOURSANIDIS ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Adrenal Function ◽  
Hypothalamic Pituitary Adrenal ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

scholarly journals Role of thyroid metabolism in vestibular vertigo

2020 ◽  
Vol 6 (2) ◽  
pp. 359
Author(s):  
Anisa . ◽  
Sheetal Rai
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Control Group ◽  
Large Sample Size ◽  
Thyroid Function Tests ◽  
Hormone Levels ◽  
Thyroid Metabolism ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

<p class="abstract"><strong>Background:</strong> Thyroid hormones play a role in the development and functioning of the inner ear.  Therefore, it was hypothesized that a derangement in the thyroid hormone levels can affect the cochleo-vestibular system.</p><p class="abstract"><strong>Methods:</strong> The present study included 64 cases and 64 controls. All patients diagnosed with peripheral vertigo were enrolled into the study. All the subjects underwent thyroid function tests- serum T3, T4 and thyroid stimulating hormone (TSH). Free hormone levels were obtained in patients with subclinical hypo or hyperthyroidism. The data was analyzed using Independent sample t test.  </p><p class="abstract"><strong>Results:</strong> Out of 64 cases only 10 patients showed altered thyroid values. Fifty-nine cases were diagnosed with benign paroxysmal positional vertigo (BPPV) out of which 9 (15%) had altered thyroid hormone levels. Among the control group, 12 were found to have deranged thyroid hormone levels.</p><p class="abstract"><strong>Conclusions:</strong> There is no association between functional thyroid hormone levels and BPPV. Therefore, altered thyroid metabolism has no role in the causation of vestibular dysfunction due to BPPV. However, in case of Meniere’s disease and Vestibular neuronitis further studies with large sample size are required to ascertain the role of functional thyroid hormones in producing vestibular symptoms.</p>

Hypermetabolism in Gaucher disease type I is not associated with altered thyroid hormone levels

2007 ◽  
Vol 30 (6) ◽  
pp. 985-985 ◽  
Author(s):  
M. Langeveld ◽  
E. Endert ◽  
W. M. Wiersinga ◽  
J. M. F. G. Aerts ◽  
C. E. M. Hollak
Keyword(s):  
Thyroid Hormone ◽  
Gaucher Disease ◽  
Disease Type ◽  
Type I ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

scholarly journals Small for Gestational Age is a Risk Factor for Thyroid Dysfunction in Preterm Newborns

2020 ◽  
Author(s):  
Chunhua Liu ◽  
Kaiyan Wang ◽  
Jizhong Guo ◽  
Jiru Chen ◽  
Mei Chen ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Thyroid Dysfunction ◽  
Z Score ◽  
Normal Range ◽  
Free Triiodothyronine ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Altered Thyroid

Abstract Background Thyroid hormones play an important role in the normal growth and maturation of the central nervous system. However, few publications addressed the altered thyroid hormone levels in preterm small for gestational age (SGA) newborns. We hypothesized preterm SGA infants have higher thyroid-stimulating hormone (TSH) concentrations than appropriate for gestational age (AGA) ones within the normal range and an increased incidence of thyroid dysfunction. Methods The study was designed to compare thyroid hormone levels within the normal range and the incidence of thyroid dysfunction in the SGA and AGA groups to test the hypothesis. Blood samples were collected between 72 and 96 hours of life and analyzed with TSH, free thyroxine (FT4) and free triiodothyronine (FT3) assays. Thyroid function test (TFT) results, and neonatal demographic and clinical factors were analyzed to identify the associations between SGA birth and altered thyroid concentrations and thyroid dysfunction. Results TSH and FT4 concentrations were significantly higher in the SGA group than the AGA group ((4.89(interquartile range (IQR): 2.62~7.59) vs. 3.15(IQR: 1.86~5.42) mU/L, p=0.015), and (18.64±4.39 vs. 17.40±3.70 pmol/L, p=0.037), respectively). The higher TSH levels were associated with being SGA or Z-score of birth weight (BW) for GA after adjusting for potential confounders (( β SGA =1.28 (95% confidence interval (CI) 0.45~2.12), p=0.003) or ( β Z-score =-0.25 (95%CI -0.48~-0.03), p=0.028), respectively). However, we did not find a significant association between SGA birth and altered FT4 concentrations. Furthermore, compared with the AGA group, the SGA group presented an increased incidence of transient hypothyroxinemia with delayed TSH elevation (dTSHe) (odds ratio (OR) =8.75(95%CI 0.71~78.02)), a higher percentage receiving levothyroxine (L-T4) therapy (OR=1.80 (95%CI 0.98~3.21)), and a higher rate of follow-up within the first 6 months of life (OR=1.82 (95%CI 0.93~3.39)). Conclusions Preterm SGA newborns had significantly higher TSH concentrations within the normal range and an increased incidence of thyroid dysfunction. The SGA newborns with these features should be closely followed up with periodical TFTs and endocrinologic evaluation.

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