Subchronic cadmium exposure upregulates the mRNA level of genes associated to hepatic lipid metabolism in adult female CD1 mice

2018 ◽  
Vol 38 (7) ◽  
pp. 1026-1035 ◽  
Author(s):  
Jun Zhang ◽  
Yan Wang ◽  
Lin Fu ◽  
Yu-Jie Feng ◽  
Yan-Li Ji ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Adult Female ◽  
Mrna Level ◽  
Cadmium Exposure ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Cd1 Mice

scholarly journals Impact of Dietary Crude Protein Level on Hepatic Lipid Metabolism in Weaned Female Piglets

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1829
Author(s):  
Ning Liu ◽  
Yun Ji ◽  
Ying Yang ◽  
Hai Jia ◽  
Xuemeng Si ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Crude Protein ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Fatty Acid Synthase ◽  
Mrna Level ◽  
Building Blocks ◽  
Peroxisome Proliferator ◽  
Hepatic Lipid Metabolism ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hepatic Lipid

Amino acids serve not only as building blocks for proteins, but also as substrates for the synthesis of low-molecular-weight substances involved in hepatic lipid metabolism. In the present study, eighteen weaned female piglets at 35 days of age were fed a corn- and soybean meal-based diet containing 20%, 17%, or 14% crude protein (CP), respectively. We found that 17% or 20% CP administration reduced the triglyceride and cholesterol concentrations, while enhanced high-density lipoprotein cholesterol (HDL-C) concentration in serum. Western blot analysis showed that piglets in the 20% CP group had higher protein abundance of hormone-sensitive triglyceride lipase (HSL) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), as compared with other groups. Moreover, the mRNA expression of sterol regulatory element binding transcription factor 1 (SREBPF1), fatty acid synthase (FASN), and stearoyl-CoA desaturase (SCD) were lower in the 17% or 20% CP group, compared with those of the piglets administered with 14% CP. Of note, the mRNA level of acetyl-CoA carboxylase alpha (ACACα) was lower in the 17% CP group, compared with other groups. Additionally, the mRNA level of lipoprotein lipase (LPL), peroxisome proliferator-activated receptor alpha α (PPARα), glucose-6-phosphatase catalytic subunit (G6PC), and phosphoenolpyruvate carboxykinase 1 (PKC1) in the liver of piglets in the 20% CP group were higher than those of the 14% CP group. Collectively, our results demonstrated that dietary CP could regulate hepatic lipid metabolism through altering hepatic lipid lipogenesis, lipolysis, oxidation, and gluconeogenesis.

scholarly journals Type and amount of maternal dietary fat induce altered hepatic lipid metabolism in adult female offspring in rats

2011 ◽  
Vol 70 (OCE4) ◽  
Author(s):  
M. Sahota ◽  
N. A. Irvine ◽  
C. Kelsall ◽  
C. Torrens ◽  
K. A. Lillycrop ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Adult Female ◽  
Dietary Fat ◽  
Female Offspring ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Altered hepatic lipid metabolism in leptin-deficlent mice

2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Prenatal programming of hepatic lipid metabolism: Sex, hormones and lifelong health

2020 ◽  
Author(s):  
Katarzyna Siemienowicz ◽  
Panagiotis Filis ◽  
Chiara Talia ◽  
Jennifer Thomas ◽  
Paul Fowler ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Sex Hormones ◽  
Prenatal Programming ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

SPARC inhibition accelerates NAFLD‐associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism

2021 ◽  
Author(s):  
Agostina Onorato ◽  
Esteban Fiore ◽  
Juan Bayo ◽  
Cecilia Casali ◽  
María Fernandez‐Tomé ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid
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