Development of haemostatic decontaminants for treatment of wounds contaminated with chemical warfare agents. 3: Evaluation of in vitro topical decontamination efficacy using damaged skin

2017 ◽  
Vol 37 (8) ◽  
pp. 976-984 ◽  
Author(s):  
Helen L. Lydon ◽  
Charlotte A. Hall ◽  
Christopher H. Dalton ◽  
J. Kevin Chipman ◽  
John S. Graham ◽  
...  
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Warfare Agents ◽  
Treatment Of Wounds

The in vitro efficacy of haemostatic products in the presence of chemical warfare agents—Sulphur mustard (HD) and VX

Toxicology ◽  
2009 ◽  
Vol 262 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Charlotte A. Hall ◽  
Helen L. Lydon ◽  
Christopher H. Dalton ◽  
J. Kevin Chipman ◽  
Robert P. Chilcott ◽  
...  
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Sulphur Mustard ◽  
Warfare Agents

Some Possibilities to Study New Prophylactics against Nerve Agents

2019 ◽  
Vol 19 (12) ◽  
pp. 970-979 ◽  
Author(s):  
J. Bajgar ◽  
J. Kassa ◽  
T. Kucera ◽  
K. Musilek ◽  
D. Jun ◽  
...  
Keyword(s):  
Cholinesterase Inhibitors ◽  
Chemical Warfare Agents ◽  
Nerve Agents ◽  
Chemical Warfare ◽  
Huperzine A ◽  
Acetylcholinesterase Inhibition ◽  
Effective Prophylaxis ◽  
Warfare Agents

Nerve agents belong to the most dangerous chemical warfare agents and can be/were misused by terrorists. Effective prophylaxis and treatment is necessary to diminish their effect. General principles of prophylaxis are summarized (protection against acetylcholinesterase inhibition, detoxification, treatment “in advance” and use of different drugs). They are based on the knowledge of mechanism of action of nerve agents. Among different examinations, it is necessary to test prophylactic effectivity in vivo and compare the results with protection in vitro. Chemical and biological approaches to the development of new prophylactics would be applied simultaneously during this research. Though the number of possible prophylactics is relatively high, the only four drugs were introduced into military medical practice. At present, pyridostigmine seems to be common prophylactic antidote; prophylactics panpal (tablets with pyridostigmine, trihexyphenidyl and benactyzine), transant (transdermal patch containing HI-6) are other means introduced into different armies as prophylactics. Scavenger commercionally available is Protexia®. Future development will be focused on scavengers, and on other drugs either reversible cholinesterase inhibitors (e.g., huperzine A, gallantamine, physostigmine, acridine derivatives) or other compounds.

Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 2: Evaluation ofin vitrotopical decontamination efficacy using undamaged skin

2014 ◽  
Vol 35 (5) ◽  
pp. 543-550 ◽  
Author(s):  
Christopher H. Dalton ◽  
Charlotte A. Hall ◽  
Helen L. Lydon ◽  
J. K. Chipman ◽  
John S. Graham ◽  
...  
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Warfare Agents ◽  
Treatment Of Wounds

Protective effects of clothing on the in vitro absorption of chemical warfare agents

Toxicology ◽  
2010 ◽  
Vol 278 (3) ◽  
pp. 344
Author(s):  
Hazem Matar ◽  
Shirley C. Price ◽  
Robert P. Chilcott
Keyword(s):  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Protective Effects ◽  
Warfare Agents
Sign in / Sign up

Export Citation Format

Share Document