Oxidative stress-mediated developmental toxicity induced by isoniazide in zebrafish embryos and larvae

2017 ◽  
Vol 37 (7) ◽  
pp. 842-852 ◽  
Author(s):  
Yu Zou ◽  
Yun Zhang ◽  
Liwen Han ◽  
Qiuxia He ◽  
Hairong Hou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos

scholarly journals Roots and stems of Kadsura coccinea extract induced developmental toxicity in zebrafish embryos/larvae through apoptosis and oxidative stress

2020 ◽  
Vol 58 (1) ◽  
pp. 1294-1301
Author(s):  
Zhongshang Xia ◽  
Erwei Hao ◽  
Zhangmei Chen ◽  
Mingzhe Zhang ◽  
Yanting Wei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
Kadsura Coccinea ◽  
And Oxidative Stress

Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway

Chemosphere ◽  
2020 ◽  
Vol 246 ◽  
pp. 125727 ◽  
Author(s):  
Zhenzhen Song ◽  
Yun Zhang ◽  
Huazheng Zhang ◽  
R. Samuel Rajendran ◽  
Rongchun Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
And Oxidative Stress

scholarly journals Cardiovascular Effects of PCB 126 (3,3’,4,4’,5-Pentachlorobiphenyl) in Zebrafish Embryos and Impact of Co-Exposure to Redox Modulating Chemicals

2019 ◽  
Vol 20 (5) ◽  
pp. 1065 ◽  
Author(s):  
Elisabet Teixidó ◽  
Marta Barenys ◽  
Ester Piqué ◽  
Joan Llobet ◽  
Jesús Gómez-Catalán
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Environmental Pollutants ◽  
Cardiovascular Effects ◽  
Zebrafish Embryos ◽  
Oxidative Potential ◽  
Antioxidant Genes ◽  
Aryl Hydrocarbon ◽  
Low Concentrations ◽  
Pericardial Edema

The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed zebrafish embryos to PCB126 or to several redox-modulating chemicals to study their ability to modulate the dysmorphogenesis produced by PCB126. PCB126 produced a concentration-dependent induction of pericardial edema and circulatory failure, and a concentration-dependent reduction of cardiac output and body length at 80 hours post fertilization (hpf). Among several modulators tested, the effects of PCB126 could be both positively and negatively modulated by different compounds; co-treatment with α-tocopherol (vitamin E liposoluble) prevented the adverse effects of PCB126 in pericardial edema, whereas co-treatment with sodium nitroprusside (a vasodilator compound) significantly worsened PCB126 effects. Gene expression analysis showed an up-regulation of cyp1a, hsp70, and gstp1, indicative of PCB126 interaction with the aryl hydrocarbon receptor (AhR), while the transcription of antioxidant genes (sod1, sod2; cat and gpx1a) was not affected. Further studies are necessary to understand the role of oxidative stress in the developmental toxicity of low concentrations of PCB126 (25 nM). Our results give insights into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of environmental pollutants.

Developmental toxicity and oxidative stress induced by gamma irradiation in zebrafish embryos

2016 ◽  
Vol 55 (4) ◽  
pp. 441-450 ◽  
Author(s):  
Miao Hu ◽  
Nan Hu ◽  
Dexin Ding ◽  
Weichao Zhao ◽  
Yongfu Feng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Irradiation ◽  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
And Oxidative Stress

scholarly journals Developmental Toxicity of Diethylnitrosamine in Zebrafish Embryos/Juveniles Related to Excessive Oxidative Stress

2018 ◽  
Vol 229 (3) ◽  
Author(s):  
Danping Huang ◽  
Hanmin Li ◽  
Qidi He ◽  
Weiqu Yuan ◽  
Zuanguang Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos

Halobenzoquinone-Induced Developmental Toxicity, Oxidative Stress, and Apoptosis in Zebrafish Embryos

2018 ◽  
Vol 52 (18) ◽  
pp. 10590-10598 ◽  
Author(s):  
Chang Wang ◽  
Xue Yang ◽  
Qi Zheng ◽  
Birget Moe ◽  
Xing-Fang Li
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos
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