scholarly journals Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents

2016 ◽  
Vol 37 (6) ◽  
pp. 732-746 ◽  
Author(s):  
Normand Podechard ◽  
Martine Chevanne ◽  
Morgane Fernier ◽  
Arnaud Tête ◽  
Aurore Collin ◽  
...  
Keyword(s):  
Membrane Remodeling ◽  
Zebrafish Larva ◽  
Chemical Agents ◽  
Reliable Model ◽  
In Vivo Assessment

In Vivo Assessment of Synovial Microcirculation and Leukocyte–Endothelial Cell Interaction in Mouse Antigen-Induced Arthritis

1999 ◽  
Vol 6 (4) ◽  
pp. 281-290 ◽  
Author(s):  
A N D R E A S VEIHELMANN ◽  
ANTHONY G U S T A V E HARRIS ◽  
F R I T Z KROMBACH ◽  
E L K E SCHÜTZE ◽  
HANS JÜRGEN REFIOR ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Interaction ◽  
Endothelial Cell Interaction ◽  
In Vivo Assessment

In vivo assessment of anti-CD34 coated ePTFE vascular prostheses

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
W Mrowczynski ◽  
A Rungatscher ◽  
F Buchegger ◽  
JC Tille ◽  
D Mugnai ◽  
...  
Keyword(s):  
Vascular Prostheses ◽  
In Vivo Assessment

Cyanine Fluorochrome-Labeled Antibodies in Vivo: Assessment of Tumor Imaging Using Cy3, Cy5, Cy5.5, and Cy7

1998 ◽  
Vol 22 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Byron Ballou ◽  
Gregory W. Fisher ◽  
Jau-Shyong Deng ◽  
Thomas R. Hakala ◽  
Meera Srivastava ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
In Vivo Assessment

scholarly journals Noninvasive, in vivo assessment of the cervical microcirculation using incident dark field imaging

2021 ◽  
Vol 135 ◽  
pp. 104145
Author(s):  
Yani P. Latul ◽  
Arnoud W. Kastelein ◽  
Patricia W.T. Beemster ◽  
Nienke E. van Trommel ◽  
Can Ince ◽  
...  
Keyword(s):  
Dark Field ◽  
Dark Field Imaging ◽  
Incident Dark Field Imaging ◽  
Field Imaging ◽  
In Vivo Assessment

scholarly journals In vivo assessment of a single adenine mutation in 5′UTR of Endothelin-1 gene in paediatric cases with severe pulmonary hypertension: an observational study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Abhishek Kumar ◽  
Minati Choudhury ◽  
Sakshi Dhingra Batra ◽  
Kriti Sikri ◽  
Anushree Gupta
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart ◽  
Small Sample Size ◽  
Small Sample ◽  
Severe Pulmonary Hypertension ◽  
Endothelin 1 ◽  
Circulating Levels ◽  
In Vivo Assessment

Abstract Objective Endothelin-1 plays an important role in the pathogenesis of severe pulmonary hypertension. The + 139 ‘A’, adenine insertion variant in 5′UTR of edn1 gene has been reported to be associated with increased expression of Endothelin-1 in vitro. The aim of present study was to explore the association of this variant with the circulating levels of Endothelin-1 in vivo using archived DNA and plasma samples from 38 paediatric congenital heart disease (cyanotic and acyanotic) patients with severe pulmonary hypertension. Results The plasma Endothelin-1 levels were highly varied ranging from 1.63 to75.16 pg/ml. The + 139 ‘A’ insertion variant in 5′UTR of edn1 was seen in 8 out of 38 cases with only one acyanotic sample demonstrating homozygosity of inserted ‘A’ allele at + 139 site (4A/4A genotype). The plasma Endothelin-1 levels in children with homozygous variant 3A/3A genotype were comparable in cyanotic and acyanotic groups. Lone 4A/4A acyanotic sample had ET-1 levels similar to the median value of ET-1 associated with 3A/3A genotype and was absent in cyanotic group presumably due to deleterious higher ET-1 levels. The discussed observations, limited by the small sample size, are suggestive of homozygous adenine insertion variant posing a risk in cyanotic babies with Severe Pulmonary Hypertension.

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