In vitroevaluation of the cytotoxic and genotoxic effects of artemether, an antimalarial drug, in a gastric cancer cell line (PG100)

2011 ◽  
Vol 33 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Diego Di Felipe Ávila Alcântara ◽  
Helem Ferreira Ribeiro ◽  
Plínio Cerqueira dos Santos Cardoso ◽  
Taíssa Maíra Thomaz Araújo ◽  
Rommel Rodriguez Burbano ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Antimalarial Drug ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Genotoxic Effects

scholarly journals Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line

2021 ◽  
Vol 22 (14) ◽  
pp. 7698
Author(s):  
Sara Peri ◽  
Alessio Biagioni ◽  
Giampaolo Versienti ◽  
Elena Andreucci ◽  
Fabio Staderini ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Intracellular Signaling ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Tumor Evolution ◽  
Selective Growth Advantage

Chemotherapy is still widely used as a coadjutant in gastric cancer when surgery is not possible or in presence of metastasis. During tumor evolution, gatekeeper mutations provide a selective growth advantage to a subpopulation of cancer cells that become resistant to chemotherapy. When this phenomenon happens, patients experience tumor recurrence and treatment failure. Even if many chemoresistance mechanisms are known, such as expression of ATP-binding cassette (ABC) transporters, aldehyde dehydrogenase (ALDH1) activity and activation of peculiar intracellular signaling pathways, a common and universal marker for chemoresistant cancer cells has not been identified yet. In this study we subjected the gastric cancer cell line AGS to chronic exposure of 5-fluorouracil, cisplatin or paclitaxel, thus selecting cell subpopulations showing resistance to the different drugs. Such cells showed biological changes; among them, we observed that the acquired chemoresistance to 5-fluorouracil induced an endothelial-like phenotype and increased the capacity to form vessel-like structures. We identified the upregulation of thymidine phosphorylase (TYMP), which is one of the most commonly reported mutated genes leading to 5-fluorouracil resistance, as the cause of such enhanced vasculogenic ability.

scholarly journals Downregulation of c-Met expression does not enhance the sensitivity of gastric cancer cell line MKN-45 to gefitinib

2014 ◽  
Vol 11 (3) ◽  
pp. 2269-2275 ◽  
Author(s):  
JIN-AN MA ◽  
CHUNHONG HU ◽  
WENJUAN LI ◽  
JING REN ◽  
FANGWEN ZOU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line

scholarly journals Establishment of an α-Fetoprotein-producing Gastric Cancer Cell Line in Serum-free Media

1991 ◽  
Vol 82 (8) ◽  
pp. 883-885 ◽  
Author(s):  
Masanori Terashima ◽  
Kenichiro Ikeda ◽  
Chihaya Maesawa ◽  
Hidenobu Kawamura ◽  
Yorikazu Niitsu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Serum Free ◽  
Free Media

scholarly journals New prognostic markers revealed by RNA-Seq transcriptome analysis after MYC silencing in a metastatic gastric cancer cell line

Oncotarget ◽  
2019 ◽  
Vol 10 (56) ◽  
pp. 5768-5779 ◽  
Author(s):  
Luana de O. Lopes ◽  
Jersey H. Maués ◽  
Hygor Ferreira-Fernandes ◽  
France K. Yoshioka ◽  
Severino C. Sousa Júnior ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Transcriptome Analysis ◽  
Gastric Cancer Cell ◽  
Prognostic Markers ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Metastatic Gastric Cancer ◽  
Rna Seq
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