Dark cell change of the cerebellar Purkinje cells induced by terbutaline under transient disruption of the blood-brain barrier in adult rats: morphological evaluation

2011 ◽  
Vol 32 (10) ◽  
pp. 790-795 ◽  
Author(s):  
Naoaki Yamada ◽  
Satoshi Sasaki ◽  
Hiroyuki Ishii ◽  
Junko Sato ◽  
Takeshi Kanno ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Adult Rats ◽  
Dark Cell ◽  
Morphological Evaluation ◽  
Blood Brain ◽  
Cerebellar Purkinje Cells

scholarly journals Restraint Stress-Induced Morphological Changes at the Blood-Brain Barrier in Adult Rats

2016 ◽  
Vol 8 ◽  
Author(s):  
Petra Sántha ◽  
Szilvia Veszelka ◽  
Zsófia Hoyk ◽  
Mária Mészáros ◽  
Fruzsina R. Walter ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Restraint Stress ◽  
Morphological Changes ◽  
Brain Barrier ◽  
Adult Rats ◽  
Blood Brain

scholarly journals Restraint Stress Induced Hyperpermeability and Damage of the Blood-Brain Barrier in the Amygdala of Adult Rats

2019 ◽  
Vol 12 ◽  
Author(s):  
Guangming Xu ◽  
Yingmin Li ◽  
Chunling Ma ◽  
Chuan Wang ◽  
Zhaoling Sun ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Restraint Stress ◽  
Brain Barrier ◽  
Adult Rats ◽  
Blood Brain

Blood-brain barrier to albumin in embryonic new born and adult rats

1968 ◽  
Vol 10 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Yngve Olsson ◽  
Igor Klatzo ◽  
Patrick Sourander ◽  
Oskar Steinwall
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Adult Rats ◽  
New Born ◽  
Blood Brain

Accumulation of plasma proteins in Purkinje cells as an indicator of blood-brain barrier breakdown

2004 ◽  
Vol 146 (2-3) ◽  
pp. 121-124 ◽  
Author(s):  
H. Ikegaya ◽  
J. Heino ◽  
H. Laaksonen ◽  
S. Toivonen ◽  
H. Kalimo ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Blood Brain Barrier ◽  
Plasma Proteins ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown

scholarly journals Transfer Constants for Blood-Brain Barrier Permeation of the Neuroexcitatory Shellfish Toxin, Domoic Acid

1991 ◽  
Vol 18 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Edward Preston ◽  
Ivo Hynie
Keyword(s):  
Blood Brain Barrier ◽  
Domoic Acid ◽  
Carrier Transport ◽  
Polar Compounds ◽  
Brain Regions ◽  
Brain Barrier ◽  
Adult Rats ◽  
Mean Values ◽  
Blood Brain ◽  
The Brain

ABSTRACT:The cause of the toxic mussel poisoning episode in 1987 was traced to a plankton-produced excitotoxin, domoic acid. Experiments were undertaken to quantitate the degree to which blood-borne domoic acid can permeate the microvasculature to enter the brain. Pentobarbital-anesthetized, adult rats received an i.v. injection of 3H-domoic acid which was permitted to circulate for 3-60 min. Transfer constants (Ki) describing blood-to-brain diffusion of tracer were calculated from analysis of the relationship between brain vs plasma radioactivity with time. Mean values (mL.g-1.s-1 x 106) for permeation into 7 brain regions (n = 10 rats) ranged from 1.60 ± 0.13 (SE) to 1.86 ± 0.33 (cortex, ponsmedulla respectively), and carrier transport or regional selectivity in uptake were not evident. Nephrectomy prior to domoic acid injection resulted in the elevation of circulating plasma tracer level and brain uptake. The Ki values are comparable to those for other polar compounds such as sucrose, and indicate that the blood-brain barrier greatly limits the amount of toxin that enters the brain. Together with absorbed dosage, integrity of the cerebrovascular barrier and normal kidney function are important to the outcome of accidentally ingesting domoic acid.

Vulnerability to Cerebral Hypoxic-Ischemic Insult in Neonatal but Not in Adult Rats Is in Parallel With Disruption of the Blood-Brain Barrier

Stroke ◽  
1997 ◽  
Vol 28 (11) ◽  
pp. 2281-2289 ◽  
Author(s):  
Kanji Muramatsu ◽  
Atsuo Fukuda ◽  
Hajime Togari ◽  
Yoshiro Wada ◽  
Hitoo Nishino
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Ischemic Insult ◽  
Adult Rats ◽  
Blood Brain

scholarly journals In Vitro Blood-Brain Barrier Models Using Brain Capillary Endothelial Cells Isolated from Neonatal and Adult Rats Retain Age-Related Barrier Properties

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e55166 ◽  
Author(s):  
Fuyuko Takata ◽  
Shinya Dohgu ◽  
Atsushi Yamauchi ◽  
Junichi Matsumoto ◽  
Takashi Machida ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Barrier Properties ◽  
Brain Barrier ◽  
Adult Rats ◽  
Brain Capillary ◽  
Blood Brain ◽  
Age Related ◽  
Capillary Endothelial Cells

scholarly journals Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
H. B. Stolp ◽  
P. A. Johansson ◽  
M. D. Habgood ◽  
K. M. Dziegielewska ◽  
N. R. Saunders ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Systemic Inflammation ◽  
Brain Barrier ◽  
Adult Rats ◽  
Dark Light ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
The Impact

Several neurological disorders have been linked to inflammatory insults suffered during development. We investigated the effects of neonatal systemic inflammation, induced by LPS injections, on blood-brain barrier permeability, endothelial tight junctions and behaviour of juvenile (P20) and adult rats. LPS-treatment resulted in altered cellular localisation of claudin-5 and changes in ultrastructural morphology of a few cerebral blood vessels. Barrier permeability to sucrose was significantly increased in LPS treated animals when adult but not at P20 or earlier. Behavioural tests showed that LPS treated animals at P20 exhibited altered behaviour using prepulse inhibition (PPI) analysis, whereas adults demonstrated altered behaviour in the dark/light test. These data indicate that an inflammatory insult during brain development can change blood-brain barrier permeability and behaviour in later life. It also suggests that the impact of inflammation can occur in several phases (short- and long-term) and that each phase might lead to different behavioural modifications.

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