A novel 7-azaisoindigo derivative-induced cancer cell apoptosis and mitochondrial dysfunction mediated by oxidative stress

2010 ◽  
pp. n/a-n/a
Author(s):  
Jing-jing Xu ◽  
Xiao-min Dai ◽  
Hai-liang Liu ◽  
Wen-jie Guo ◽  
Jing Gao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

2018 ◽  
Vol 9 (11) ◽  
pp. 5536-5546 ◽  
Author(s):  
Yang Wang ◽  
Yang-Jia Li ◽  
Xiao-Hui Huang ◽  
Can-Can Zheng ◽  
Xing-Feng Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dysfunction ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Quantitative Proteomics ◽  
Food Source ◽  
Colorectal Cancer Cell ◽  
Functional Screen ◽  
Cancer Cell Apoptosis

Functional screen and quantitative proteomics reveal that food-source liensinine induces colorectal cancer cell apoptosisviathe JNK-mitochondrial dysfunction signaling pathway.

scholarly journals Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis

2020 ◽  
Vol 11 (12) ◽  
pp. 3215-3222
Author(s):  
Xinming Li ◽  
Yanan Hou ◽  
Jintao Zhao ◽  
Jin Li ◽  
Song Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis ◽  
And Oxidative Stress

The 1,2-diselenolane unit is a general scaffold to construct glutathione-dependent prodrugs that show increased potency to cancer cells, and work via a combination of chemotherapy and oxidative stress.

scholarly journals Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

2012 ◽  
Vol 13 (3) ◽  
pp. 138-147 ◽  
Author(s):  
Wang Zhiyu ◽  
Cheng Yue ◽  
Wang Neng ◽  
Wang Dong Mei ◽  
Li Ying Wei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

scholarly journals p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis

2020 ◽  
Vol 22 (1) ◽  
pp. 155-164
Author(s):  
Jiuling Li ◽  
Yany Li ◽  
Lanlan Chen ◽  
Bingbing Yu ◽  
Yanan Xue ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Prostate Cancer Cell ◽  
Cancer Cell Apoptosis

Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis

2016 ◽  
Vol 4 (13) ◽  
pp. 2351-2358 ◽  
Author(s):  
Tianqi Nie ◽  
Hualian Wu ◽  
Ka-Hing Wong ◽  
Tianfeng Chen
Keyword(s):  
Mitochondrial Dysfunction ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Selenium Nanoparticles ◽  
Facile Synthesis ◽  
Cancer Cell Apoptosis ◽  
Intracellular Ros ◽  
Induction Of Apoptosis ◽  
Highly Uniform ◽  
Induce Cancer Cell Apoptosis

Herein, we demonstrated a new and facial synthesis of highly uniformed SeNPs using glucose as the reductant and surface decorator. Glu–SeNPs induced cancer cell apoptosisviainduction of apoptosis by triggering intracellular ROS overproduction and mitochondrial dysfunction.

Elesclomol induces cancer cell apoptosis through oxidative stress

2008 ◽  
Vol 7 (8) ◽  
pp. 2319-2327 ◽  
Author(s):  
Jessica R. Kirshner ◽  
Suqin He ◽  
Vishwasenani Balasubramanyam ◽  
Jane Kepros ◽  
Chin-Yu Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis

scholarly journals Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Wang ◽  
Liming Zhu ◽  
Mei Guo ◽  
Gang Sun ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
B Cell Lymphoma ◽  
Histone Methyltransferase ◽  
Chemotherapeutic Agents ◽  
Cancer Cell Apoptosis ◽  
Active Transcription

AbstractWHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. In this study, we revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer (CRC). Our data showed that WHSC1 as well as H3K36me2 were highly expressed in clinical CRC samples, and high WHSC1 expression is associated with poorer prognosis in CRC patients. WHSC1 reduction promoted colon cancer cell apoptosis both in vivo and in vitro. We found that B cell lymphoma-2 (BCL2) expression, an anti-apoptotic protein, is markedly decreased in after WHSC1 depletion. Mechanistic characterization indicated that WHSC1 directly binds to the promoter region of BCL2 gene and regulate its H3K36 dimethylation level. What’s more, our study indicated that WHSC1 depletion promotes chemosensitivity in CRC cells. Together, our results suggested that WHSC1 and H3K36me2 modification might be optimal therapeutic targets to disrupt CRC progression and WHSC1-targeted therapy might potentially overcome the resistance of chemotherapeutic agents.

Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis

2020 ◽  
Vol 21 (10) ◽  
pp. 571-582
Author(s):  
Jia Qi Li ◽  
Jia Lu Li ◽  
Yuan Hong Xie ◽  
Yao Wang ◽  
Xiao Nan Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Saccharomyces Cerevisiae ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cancer Cell Apoptosis
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