Both DNA damage and mitochondrial dysfunction are involved in novel oxadiazolo[3,4-d]pyrimidine nucleoside derivatives-induced cancer cell death

2009 ◽  
Vol 29 (6) ◽  
pp. 489-495 ◽  
Author(s):  
Hai-liang Liu ◽  
Jing-jing Xu ◽  
Xiao-min Dai ◽  
Jing-Bo Shi ◽  
Song Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Cancer Cell ◽  
Pyrimidine Nucleoside ◽  
Cancer Cell Death

Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

2021 ◽  
Author(s):  
Wooram Park ◽  
Seok-Jo Kim ◽  
Paul Cheresh ◽  
Jeanho Yun ◽  
Byeongdu Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Cancer Cell ◽  
High Sensitivity ◽  
Intrinsic Pathway ◽  
Cancer Cell Death

Mitochondria are crucial regulators of the intrinsic pathway of cancer cell death. The high sensitivity of cancer cells to mitochondrial dysfunction offers opportunities for emerging targets in cancer therapy. Herein,...

New Fe(iii) and Co(ii) salen complexes with pendant distamycins: selective targeting of cancer cells by DNA damage and mitochondrial pathways

2016 ◽  
Vol 45 (22) ◽  
pp. 9345-9353 ◽  
Author(s):  
Asfa Ali ◽  
Mohini Kamra ◽  
Arunoday Bhan ◽  
Subhrangsu S. Mandal ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Salen Complexes ◽  
Selective Targeting

Distamycin like moieties conjugated with core Fe(iii) and Co(ii) based salens were synthesized and studied. The metal complexes showed better and differential activity toward cancer cell death.

scholarly journals Canady Helios Cold Plasma Induces Breast Cancer Cell Death by Oxidation of Histone mRNA

2021 ◽  
Vol 22 (17) ◽  
pp. 9578
Author(s):  
Xiaoqian Cheng ◽  
Saravana R. K. Murthy ◽  
Taisen Zhuang ◽  
Lawan Ly ◽  
Olivia Jones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Damage ◽  
Cell Death ◽  
Cancer Cell ◽  
Cold Plasma ◽  
S Phase ◽  
Histone Mrna ◽  
Cancer Cell Death ◽  
Marker Status

Breast cancer is the most common cancer among women worldwide. Its molecular receptor marker status and mutational subtypes complicate clinical therapies. Cold atmospheric plasma is a promising adjuvant therapy to selectively combat many cancers, including breast cancer, but not normal tissue; however, the underlying mechanisms remain unexplored. Here, four breast cancer cell lines with different marker status were treated with Canady Helios Cold Plasma™ (CHCP) at various dosages and their differential progress of apoptosis was monitored. Inhibition of cell proliferation, induction of apoptosis, and disruption of the cell cycle were observed. At least 16 histone mRNA types were oxidized and degraded immediately after CHCP treatment by 8-oxoguanine (8-oxoG) modification. The expression of DNA damage response genes was up-regulated 12 h post-treatment, indicating that 8-oxoG modification and degradation of histone mRNA during the early S phase of the cell cycle, rather than DNA damage, is the primary cause of cancer cell death induced by CHCP. Our report demonstrates for the first time that CHCP effectively induces cell death in breast cancer regardless of subtyping, through histone mRNA oxidation and degradation during the early S phase of the cell cycle.

Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death

2012 ◽  
Vol 64 (6) ◽  
pp. 1515-1525 ◽  
Author(s):  
José M. Calderón-Montaño ◽  
Estefanía Burgos-Morón ◽  
Manuel L. Orta ◽  
Nuria Pastor ◽  
Concepción Perez-Guerrero ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death
Sign in / Sign up

Export Citation Format

Share Document