Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits

2009 ◽  
Vol 29 (5) ◽  
pp. 381-385 ◽  
Author(s):  
Zhu Jiangbo ◽  
Wan Xuying ◽  
Zhu Yuping ◽  
Ma Xili ◽  
Zheng Yiwen ◽  
...  
Keyword(s):  
New Zealand ◽  
Fetal Development ◽  
Sprague Dawley ◽  
Astragaloside Iv ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

scholarly journals An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits

2018 ◽  
Vol 7 (6) ◽  
pp. 1225-1235
Author(s):  
Ronghua Li ◽  
Tingting Zhang ◽  
Mei Qin ◽  
Peng Yue ◽  
Ming Cai ◽  
...  
Keyword(s):  
New Zealand ◽  
Fetal Development ◽  
Toxicity Study ◽  
Ginkgolide B ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

The potential effects of dimethylaminoethyl ginkgolid B on pregnant dams and embryo-fetal development had been investigated in both Sprague-Dawley rats and New Zealand white rabbits.

2-Nitropropane-induced liver DNA and RNA base modifications: differences between Sprague-Dawley rats and New Zealand White rabbits

1993 ◽  
Vol 74 (1-2) ◽  
pp. 9-14 ◽  
Author(s):  
Emerich S. Fiala ◽  
Guo Nie ◽  
Rama Sodum ◽  
C.Clifford Conaway ◽  
Ock Soon Sohn
Keyword(s):  
New Zealand ◽  
Sprague Dawley ◽  
Dna And Rna ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits ◽  
Base Modifications

scholarly journals Evaluation of the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats and New Zealand White Rabbits

1996 ◽  
Vol 34 (2) ◽  
pp. 249-259
Author(s):  
JULIA D. GEORGE ◽  
CATHERINE J. PRICE ◽  
MELISSA C. MARR ◽  
CHRISTINA B. MYERS ◽  
BERNARD A. SCHWETZ ◽  
...  
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

scholarly journals Interspecies Comparison of Control Data From Embryo–Fetal Development Studies in Sprague-Dawley Rats, New Zealand White Rabbits, and Göttingen Minipigs

2019 ◽  
Vol 38 (6) ◽  
pp. 476-486
Author(s):  
France-Helene Paradis ◽  
Anne Marie Downey ◽  
Francine Beaudry ◽  
Clémentine Pinêtre ◽  
Sisse Ellemann-Laursen ◽  
...  
Keyword(s):  
New Zealand ◽  
Fetal Development ◽  
Zealand White Rabbit ◽  
Female Rats ◽  
Sprague Dawley ◽  
Skeletal Malformations ◽  
Sprague Dawley Rats ◽  
Study Results ◽  
Data Assessment ◽  
Safety Assessments

Species-dependent differences in relative incidence of spontaneous variations and malformations should be considered in the assessment of the translational value of reproductive and developmental safety assessments. The objective of this evaluation was to compare litter parameters and the frequency of external, visceral, and skeletal malformations and variations across species in the Sprague-Dawley rat, New Zealand White rabbit, and Göttingen minipig and to determine whether notable differences exist. Pregnant female rats (n = 824), rabbits (n = 540), and minipigs (n = 70) from vehicle control groups were included in the analysis, equating to 10,749 rat, 5,073 rabbit, and 378 pig fetuses collected at term by cesarean delivery. Preimplantation loss was more frequent than postimplantation loss in the rat and rabbit, whereas the opposite was observed in the minipig. Several external and visceral malformations and variations such as domed head, bent tail, abdominal edema, and anal atresia were observed in all 3 species. Visceral malformations of the heart and major blood vessels were remarkably more frequent in the minipig and rabbit, respectively; ventricular and atrium septum defects were observed in 1.9% and 2.1%, respectively, for the minipig fetuses, whereas they were observed in equal or less than 0.02% among the rat and rabbit fetuses evaluated in this study. Understanding species-dependent differences in spontaneous variations and malformations can be useful for the interpretation of embryo–fetal development study results. The current analysis identified relevant differences between commonly used species in reproductive toxicology with potential implications for data assessment.

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