Concentration of aluminium in breast cyst fluids collected from women affected by gross cystic breast disease

2009 ◽  
Vol 29 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ferdinando Mannello ◽  
Gaetana A. Tonti ◽  
Philippa D. Darbre
Keyword(s):  
Breast Disease ◽  
Breast Cyst ◽  
Gross Cystic Breast Disease ◽  
Cyst Fluids

Circulating Immune Complexes in Human Breast Cyst Fluids: Relationship with Intracystic Immunoglobulin and Electrolyte Levels

1991 ◽  
Vol 6 (2) ◽  
pp. 122-128 ◽  
Author(s):  
F. Mannello ◽  
S. Battistelli ◽  
G.D. Bocchiotti ◽  
F. Marcheggiani ◽  
R. Troccoli
Keyword(s):  
Linear Correlation ◽  
Immune Complexes ◽  
Breast Disease ◽  
Immunoglobulin M ◽  
Circulating Immune Complexes ◽  
Human Breast ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Almost All ◽  
Cyst Fluids

Circulating immune complexes, the major classes of immunoglobulins and electrolyte concentrations were measured in sixty-two breast cyst fluids aspirated in women affected by gross cystic breast disease. Two main classes of cysts were defined according to the Na/K ratio. Appreciable levels of immunoglobulins were found in almost all samples examined; 66% of breast cyst fluids showed increased levels of immune complexes. A highly significant linear correlation between increased values of immune complexes and immunoglobulin M (p < 0.001) was found in apocrine cysts, characterized by Na/K ratio <3. However, a significant inverse linear correlation was found between positive values of immune complexes and lowered levels of immunoglobulins A (p < 0.001) and G (p < 0.001) in epithelial cysts with Na/K ratio > 3. These data suggest and confirm that the menstrual cycle can also influence or modulate the metabolic activity of human breast cells as a part of the secretory immune system. The relationship between immune complexes and immunoglobulins and electrolyte profiles may provide further knowledge about the immunological features of breast cyst fluid and suggest the possible alteration of immune-response in cystic breast lesions associated with increased cancer risk

Quantification of prostate-specific antigen immunoreactivity in human breast cyst fluids

1996 ◽  
Vol 38 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Ferdinando Mannello ◽  
GianDomenico Bocchiotti ◽  
Giuseppe Bianchi ◽  
Francesco Marcheggiani ◽  
Giancarlo Gazzanelli
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Human Breast ◽  
Breast Cyst ◽  
Cyst Fluids

Steroid Hormones in Breast Cyst Fluids

1990 ◽  
Vol 586 (1 Biochemistry) ◽  
pp. 60-69 ◽  
Author(s):  
W. R. MILLER ◽  
W. N. SCOTT ◽  
R. W. KELLY ◽  
R. A. HAWKINS
Keyword(s):  
Steroid Hormones ◽  
Breast Cyst ◽  
Cyst Fluids

Benign Breast Disease

2017 ◽  
Author(s):  
Stephanie A Valente ◽  
Stephen R Grobmyer
Keyword(s):  
Benign Breast Disease ◽  
Nipple Discharge ◽  
Breast Disease ◽  
Breast Diseases ◽  
Breast Pain ◽  
Idiopathic Granulomatous Mastitis ◽  
Breast Cyst ◽  
Benign Breast Diseases ◽  
Palpable Breast ◽  
Management Recommendations

Benign breast disease constitutes any abnormality that upon further workup is found to be noncancerous and does not establish premalignant potential. Benign breast diseases can present in various ways, such as breast pain, a palpable breast lump, nipple discharge, or an imaging abnormality. Appropriate workup is essential to ensure that the new change is benign. This may entail additional imaging, biopsy, or surgery if necessary. Surgeons need to be able to recognize the presentation, appropriate workup, and treatment recommendations for the various benign breast diseases. This review addresses the broad range of benign breast lesions and their management recommendations.  This review contains 7 figures, 5 tables and 54 references Key words: benign breast disease, breast cyst, breast mass, breast pain, idiopathic granulomatous mastitis, nipple discharge, papilloma, periductal mastitis, sclerosing adenosis

Radioimmunoassay for Serum Apolipoprotein D, an Atypical Apolipoprotein: Validation and Clinical Application

1997 ◽  
Vol 34 (5) ◽  
pp. 537-542
Author(s):  
Olusola Osundeko ◽  
Lesley Tetlow ◽  
Nigel Bundred ◽  
Eric Gowland
Keyword(s):  
Breast Cancer ◽  
Solid Phase ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Breast Cyst ◽  
Structure Synthesis ◽  
Coefficients Of Variation ◽  
Increased Risk ◽  
Apolipoprotein D ◽  
Working Day

Apolipoprotein D (apoD) is an atypical apolipoprotein in terms of its structure, synthesis and probable function. It is the most abundant protein in breast cyst fluids of patients suffering from macrocystic disease of the breast, a disease associated with an increased risk of developing breast cancer. We have developed and optimized a competitive radioimmunoassay for the measurement of apoD in human serum. The assay uses a solid phase separation method and with a 4h incubation period, it can be completed in a single working day. The within and between run coefficients of variation were <8·5% and <12·2%, respectively, and quantitative recovery of apoD was obtained over the range 250–5000 μg/L. There was no difference in the serum concentrations of apoD between female controls, patients with benign breast disease and early breast cancer. However, serum apoD was significantly lower in breast cancer patients with bone metastasis.

Serum Prolactin Levels in Women with Gross Cystic Breast Disease

1992 ◽  
Vol 7 (4) ◽  
pp. 225-229 ◽  
Author(s):  
F. Vizoso ◽  
M.T. Allende ◽  
J.L. García-Muñiz ◽  
E. Alexandre ◽  
A. Fueyo ◽  
...  
Keyword(s):  
Breast Disease ◽  
Serum Prolactin ◽  
Control Group ◽  
Type I ◽  
Type Ii ◽  
Normal Range ◽  
Trh Stimulation ◽  
Gross Cystic Breast Disease ◽  
Premenopausal Patients ◽  
Normal Women

Serum prolactin (PRL) concentrations at baseline and after TRH stimulation were determined in 15 healthy women and in 51 premenopausal patients suffering from Gross Cystic Breast Disease. All women were in the luteal phase of the menstrual cycle and patients were divided into three groups according to cyst type at presentation. Basal hormone levels were within the normal range in the control group and in the three cystic breast disease groups. The maximum PRL response to TRH stimulation was significantly higher (p < 0.001) in patients with type I cysts (low Na+/K+ intracystic ratio and apocrine epithelium) than in patients with type II cysts (high Na+/K+ intracystic ratio and flattened epithelium), type III cysts (intermediate Na+/K+ intracystic ratio and mixed epithelium) and in normal women. Serum PRL concentrations corresponding to samples obtained 60 and 90 minutes after stimulation remained higher in the first group of patients. These results led us to consider the existence of an altered central regulation of PRL secretion in patients with type I cysts at presentation.

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