Estimation of benchmark dose for renal dysfunction in a cadmium non-polluted area in Japan

2006 ◽  
Vol 26 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Etsuko Kobayashi ◽  
Yasushi Suwazono ◽  
Mirei Uetani ◽  
Takeya Inaba ◽  
Mitsuhiro Oishi ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Benchmark Dose ◽  
Polluted Area

Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China

BioMetals ◽  
2004 ◽  
Vol 17 (5) ◽  
pp. 525-530 ◽  
Author(s):  
Taiyi Jin ◽  
Xunwei Wu ◽  
Yinqi Tang ◽  
Monica Nordberg ◽  
Alfred Bernard ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Epidemiological Study ◽  
Benchmark Dose ◽  
Polluted Area

scholarly journals An  assessment of sensitivity biomarkers for urinary cadmium burden

2020 ◽  
Author(s):  
Yuting Li ◽  
Hongmei Wang ◽  
Jie Yu ◽  
Qiong Yan ◽  
Honggang Hu ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Clinical Diagnosis ◽  
Benchmark Dose ◽  
National Standard ◽  
Sensitivity Index ◽  
Urinary Cadmium ◽  
Cd Exposure

Abstract Background Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urinary β 2 -microglobulin (Uβ 2 -MG) enzymes. However, the end-pointed values and the Cd burden threshold remain controversial because the scopes fluctuate widely. Methods To ascertain the clinical benchmark dose of urinary Cd (UCd) burden for renal dysfunction, 1595 residents near a Cd site were surveyed. Urine was sampled and assayed. A benchmark dose low (BMDL) was obtained by fitting UCd levels and index levels. Results We found that over 50% of the subjects were suffering from Cd exposure as their UCd levels far exceeded the national standard threshold of 5.000 μg/g creatinine (cr). Further analysis indicated that Uβ 2 -MG was more sensitive than UNAG for renal dysfunction. The BMDL for UCd was estimated as 3.486 U/g cr (male, where U is unit of enzyme) and 2.998 U/g cr (female) for UNAG. The BMDL for Uβ 2 -MG, which is released into urine from glomerulus after Cd exposure, was found to be 2.506 μg/g cr (male, where μg is the unit of microglobulin) and 2.236 μg/g cr (female). Conclusions Uβ 2 -MG is recommended as the sensitivity index for renal dysfunction, with 2.2 μg/g cr as the threshold for clinical diagnosis. Our findings suggest that Uβ 2 -MG is the better biomarker for exposure to Cd.

The association between dietary cadmium exposure and renal dysfunction - the benchmark dose estimation of reference levels: the ChinaCad study

2018 ◽  
Vol 38 (10) ◽  
pp. 1365-1373 ◽  
Author(s):  
Xiao Chen ◽  
Guoying Zhu ◽  
Zhongqiu Wang ◽  
Yihuai Liang ◽  
Bo Chen ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Cadmium Exposure ◽  
Benchmark Dose ◽  
Dose Estimation ◽  
Reference Levels ◽  
Dietary Cadmium

scholarly journals An  assessment of sensitivity biomarkers for urinary cadmium burden

2020 ◽  
Author(s):  
Yuting Li ◽  
Hongmei Wang ◽  
Jie Yu ◽  
Qiong Yan ◽  
Honggang Hu ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Clinical Diagnosis ◽  
Benchmark Dose ◽  
National Standard ◽  
Sensitivity Index ◽  
Urinary Cadmium ◽  
Cd Exposure

Abstract Background: Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urinary β2-microglobulin (Uβ2-MG) enzymes. However, the end-pointed values and the Cd burden threshold remain controversial because the scopes fluctuate widely.Methods: To ascertain the clinical benchmark dose of urinary Cd (UCd) burden for renal dysfunction, 1595 residents near a Cd site were surveyed. Urine was sampled and assayed. A benchmark dose low (BMDL) was obtained by fitting UCd levels and index levels.Results: We found that over 50% of the subjects were suffering from Cd exposure as their UCd levels far exceeded the national standard threshold of 5.000 μg/g creatinine (cr). Further analysis indicated that Uβ2-MG was more sensitive than UNAG for renal dysfunction. The BMDL for UCd was estimated as 3.486 U/g cr (male, where U is unit of enzyme) and 2.998 U/g cr (female) for UNAG. The BMDL for Uβ2-MG, which is released into urine from glomerulus after Cd exposure, was found to be 2.506 μg/g cr (male, where μg is the unit of microglobulin) and 2.236 μg/g cr (female).Conclusions: Uβ2-MG is recommended as the sensitivity index for renal dysfunction, with 2.2 μg/g cr as the threshold for clinical diagnosis. Our findings suggest that Uβ2-MG is the better biomarker for exposure to Cd.

A probabilistic approach for benchmark dose of melamine exposure for a marker of early renal dysfunction in patients with calcium urolithiasis

2020 ◽  
Vol 200 ◽  
pp. 110741
Author(s):  
Yin-Han Wang ◽  
Chia-Fang Wu ◽  
Chia-Chu Liu ◽  
Tusty-Jiuan Hsieh ◽  
Yi-Chun Tsai ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Probabilistic Approach ◽  
Benchmark Dose ◽  
Calcium Urolithiasis
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