scholarly journals Trapping of human DNA topoisomerase I by DNA structures mimicking intermediates of DNA repair

IUBMB Life ◽  
10.1002/iub.5 ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Natalia Lebedeva ◽  
Nadejda Rechkunova ◽  
Serge Boiteux ◽  
Olga Lavrik
Keyword(s):  
Dna Repair ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Dna Structures ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

DNA Repair ◽  
2007 ◽  
Vol 6 (12) ◽  
pp. 1757-1763 ◽  
Author(s):  
Christian Mielke ◽  
Faiza M. Kalfalah ◽  
Morten O. Christensen ◽  
Fritz Boege
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
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