scholarly journals Moonlighting characteristics of G protein-coupled receptors: Focus on receptor heteromers and relevance for neurodegeneration

IUBMB Life ◽  
2011 ◽  
Vol 63 (7) ◽  
pp. 463-472 ◽  
Author(s):  
Dasiel O. Borroto-Escuela ◽  
Alexander O. Tarakanov ◽  
Diego Guidolin ◽  
Francisco Ciruela ◽  
Luigi F. Agnati ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Receptor Heteromers ◽  
G Protein Coupled

scholarly journals Understanding the Added Value of G-Protein-Coupled Receptor Heteromers

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nuria Franco ◽  
Rafael Franco
Keyword(s):  
Human Genome ◽  
G Protein ◽  
Nobel Prize ◽  
Basic Research ◽  
G Protein Coupled Receptors ◽  
Added Value ◽  
G Protein Coupled Receptor ◽  
Receptor Heteromers ◽  
The Future ◽  
G Protein Coupled

G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the human genome. Since the early sixties work on GPCRs and on GPCR-mediated signaling has led to a number of awards, the most recent being the Nobel Prize in Chemistry for 2012. The future of GPCRs research is surely based on their capacity for heteromerization. Receptor heteromers offer a series of challenges that will help in providing success in academic/basic research and translation into more effective and safer drugs.

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