Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): A triad for cellular homeostasis

IUBMB Life ◽  
2010 ◽  
pp. NA-NA ◽  
Author(s):  
Sang Gyu Park ◽  
Eung-Chil Choi ◽  
Sunghoon Kim
Keyword(s):  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Cellular Homeostasis ◽  
Multifunctional Proteins

scholarly journals Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1064
Author(s):  
Muwoong Kim ◽  
Hyosun Kim ◽  
Dokyoung Kim ◽  
Chan Park ◽  
Youngbuhm Huh ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Schwann Cells ◽  
Myelin Sheath ◽  
Peripheral Nerves ◽  
Trna Synthetase ◽  
Ventral Horn ◽  
Nerve Degeneration ◽  
Aminoacyl Trna Synthetase ◽  
Multifunctional Proteins ◽  
Sheath Formation

Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs) are auxiliary factors involved in protein synthesis related to aminoacyl-tRNA synthetases (ARSs). AIMPs, which are well known as nonenzymatic factors, include AIMP1/p43, AIMP2/p38, and AIMP3/p18. The canonical functions of AIMPs include not only protein synthesis via multisynthetase complexes but also maintenance of the structural stability of these complexes. Several recent studies have demonstrated nontypical (noncanonical) functions of AIMPs, such as roles in apoptosis, inflammatory processes, DNA repair, and so on. However, these noncanonical functions of AIMPs have not been studied in peripheral nerves related to motor and sensory functions. Peripheral nerves include two types of structures: peripheral axons and Schwann cells. The myelin sheath formed by Schwann cells produces saltatory conduction, and these rapid electrical signals control motor and sensory functioning in the service of survival in mammals. Schwann cells play roles not only in myelin sheath formation but also as modulators of nerve degeneration and regeneration. Therefore, it is important to identify the main functions of Schwann cells in peripheral nerves. Here, using immunofluorescence technique, we demonstrated that AIMPs are essential morphological indicators of peripheral nerve degeneration, and their actions are limited to peripheral nerves and not the dorsal root ganglion and the ventral horn of the spinal cord.

Analysis of the aminoacyl-tRNA synthetase genes of silkworm (Bombyx mori)

2009 ◽  
Vol 31 (12) ◽  
pp. 1248-1258
Author(s):  
Guang-Li CAO ◽  
Ren-Yu XUE ◽  
Yue-Xiong ZHU ◽  
Yu-Hong WEI ◽  
Cheng-Liang GONG
Keyword(s):  
Bombyx Mori ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase

Directed evolution of an improved aminoacyl‐tRNA synthetase for incorporation of L‐3,4‐dihydroxyphenylalanine (L‐DOPA)

2021 ◽  
Author(s):  
Ross Thyer ◽  
Simon d’Oelsnitz ◽  
Molly S. Blevins ◽  
Dustin R. Klein ◽  
Jennifer S. Brodbelt ◽  
...  
Keyword(s):  
Directed Evolution ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase
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