scholarly journals FOXO transcription factors in antioxidant defense

IUBMB Life ◽  
2021 ◽  
Author(s):  
Niklas Krafczyk ◽  
Lars‐Oliver Klotz
Keyword(s):  
Transcription Factors ◽  
Antioxidant Defense ◽  
Foxo Transcription Factors

scholarly journals Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15288 ◽  
Author(s):  
Qinghe Chen ◽  
Suthakar Ganapathy ◽  
Karan P. Singh ◽  
Sharmila Shankar ◽  
Rakesh K. Srivastava
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Prostate Cancer Cells ◽  
Foxo Transcription Factors

scholarly journals 256 FOXO TRANSCRIPTION FACTORS IN ARTICULAR CHONDROCYTES

2009 ◽  
Vol 17 ◽  
pp. S141
Author(s):  
N. de Isla ◽  
N. Charif ◽  
C. Huselstein ◽  
D. Bensoussan ◽  
J.-F. Stoltz
Keyword(s):  
Transcription Factors ◽  
Articular Chondrocytes ◽  
Foxo Transcription Factors

scholarly journals Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1138
Author(s):  
Martina Schiavello ◽  
Elena Gazzano ◽  
Loredana Bergandi ◽  
Francesca Silvagno ◽  
Roberta Libener ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factors ◽  
Malignant Pleural Mesothelioma ◽  
Antioxidant Defense ◽  
Asbestos Exposure ◽  
Predictive Biomarkers ◽  
Antioxidant Systems ◽  
Pleural Mesothelioma ◽  
Related Factor ◽  
Aggressive Cancer

Although asbestos has been banned in most countries around the world, malignant pleural mesothelioma (MPM) is a current problem. MPM is an aggressive tumor with a poor prognosis, so it is crucial to identify new markers in the preventive field. Asbestos exposure induces oxidative stress and its carcinogenesis has been linked to a strong oxidative damage, event counteracted by antioxidant systems at the pulmonary level. The present study has been focused on some redox-sensitive transcription factors that regulate cellular antioxidant defense and are overexpressed in many tumors, such as Nrf2 (Nuclear factor erythroid 2-related factor 2), Ref-1 (Redox effector factor 1), and FOXM1 (Forkhead box protein M1). The research was performed in human mesothelial and MPM cells. Our results have clearly demonstrated an overexpression of Nrf2, Ref-1, and FOXM1 in mesothelioma towards mesothelium, and a consequent activation of downstream genes controlled by these factors, which in turn regulates antioxidant defense. This event is mediated by oxidative free radicals produced when mesothelial cells are exposed to asbestos fibers. We observed an increased expression of Nrf2, Ref-1, and FOXM1 towards untreated cells, confirming asbestos as the mediator of oxidative stress evoked at the mesothelium level. These factors can therefore be considered predictive biomarkers of MPM and potential pharmacological targets in the treatment of this aggressive cancer.

FOXO transcription factors in cancer development and therapy

2015 ◽  
Vol 73 (6) ◽  
pp. 1159-1172 ◽  
Author(s):  
Alexandra Coomans de Brachène ◽  
Jean-Baptiste Demoulin
Keyword(s):  
Transcription Factors ◽  
Cancer Development ◽  
Foxo Transcription Factors

FOXO Transcription Factors

2010 ◽  
pp. 2049-2057
Author(s):  
Anne Brunet ◽  
Hien Tran ◽  
Michael E. Greenberg
Keyword(s):  
Transcription Factors ◽  
Foxo Transcription Factors
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