Selectively targeting cancer stem cells: current and novel therapeutic strategies and approaches in the effective eradication of cancer

IUBMB Life ◽  
2021 ◽  
Author(s):  
Seyed‐Alireza Esmaeili ◽  
Shamim Sahranavard ◽  
Astireh Salehi ◽  
Vahid Bagheri
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Novel Therapeutic Strategies for Ovarian Cancer Stem Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Nastassja Terraneo ◽  
Francis Jacob ◽  
Anna Dubrovska ◽  
Jürgen Grünberg
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Strategies ◽  
Ovarian Cancer Stem Cells ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Cancer Stem Cells in Multiple Myeloma and the Development of Novel Therapeutic Strategies

Oncogenomics ◽  
2019 ◽  
pp. 121-137 ◽  
Author(s):  
Franco Dammacco ◽  
Patrizia Leone ◽  
Franco Silvestris ◽  
Vito Racanelli ◽  
Angelo Vacca
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Cancer Stem Cells ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies

2018 ◽  
Vol 10 ◽  
pp. 175883591881628 ◽  
Author(s):  
Nuozhou Wang ◽  
Shanshan Wang ◽  
Ming-Yue Li ◽  
Bao-guang Hu ◽  
Li-ping Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
High Capacity ◽  
Therapeutic Strategies ◽  
Small Subset ◽  
Surface Markers ◽  
Therapeutic Opportunity ◽  
Novel Therapeutic Strategies ◽  
Hcc Cells

The poor clinical outcome of hepatocellular carcinoma (HCC) patients is ascribed to the resistance of HCC cells to traditional treatments and tumor recurrence after curative therapies. Cancer stem cells (CSCs) have been identified as a small subset of cancer cells which have high capacity for self-renewal, differentiation and tumorigenesis. Recent advances in the field of liver CSCs (LCSCs) have enabled the identification of CSC surface markers and the isolation of CSC subpopulations from HCC cells. Given their central role in cancer initiation, metastasis, recurrence and therapeutic resistance, LCSCs constitute a therapeutic opportunity to achieve cure and prevent relapse of HCC. Thus, it is necessary to develop therapeutic strategies to selectively and efficiently target LCSCs. Small molecular inhibitors targeting the core stemness signaling pathways have been actively pursued and evaluated in preclinical and clinical studies. Other alternative therapeutic strategies include targeting LCSC surface markers, interrupting the CSC microenvironment, and altering the epigenetic state. In this review, we summarize the properties of CSCs in HCC and discuss novel therapeutic strategies that can be used to target LCSCs.

scholarly journals The role of adipose stem cells in inflammatory bowel disease: From biology to novel therapeutic strategies

2016 ◽  
Vol 17 (9) ◽  
pp. 889-898 ◽  
Author(s):  
Francesco De Francesco ◽  
Maurizio Romano ◽  
Laura Zarantonello ◽  
Cesare Ruffolo ◽  
Daniele Neri ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Bowel Disease ◽  
Therapeutic Strategies ◽  
Adipose Stem Cells ◽  
Inflammatory Bowel ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Targeting Cancer Stem Cells: A Strategy for Effective Eradication of Cancer

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 732 ◽  
Author(s):  
Masahiro Shibata ◽  
Mohammad Obaidul Hoque
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Cells ◽  
Therapeutic Strategies ◽  
Conventional Chemotherapy ◽  
Targeting Therapy ◽  
Main Challenge ◽  
Promote Cell Survival ◽  
Xenograft Models ◽  
Novel Therapeutic Strategies

Cancer stem cells (CSCs) are subpopulations of tumor cells with the ability to self-renew, differentiate, and initiate and maintain tumor growth, and they are considered to be the main drivers of intra- and inter-tumoral heterogeneity. While conventional chemotherapy can eradicate the majority of non-CSC tumor cells, CSCs are often drug-resistant, leading to tumor recurrence and metastasis. The heterogeneity of CSCs is the main challenge in developing CSC-targeting therapy; therefore, we and other investigators have focused on developing novel therapeutic strategies that combine conventional chemotherapy with inhibitors of CSC-regulating pathways. Encouraging preclinical findings have suggested that CSC pathway blockade can indeed enhance cellular sensitivity to non-targeted conventional therapy, and this work has led to several ongoing clinical trials of CSC pathway inhibitors. Our studies in bladder cancer and lung adenocarcinoma have demonstrated a crucial role of YAP1, a transcriptional regulator of genes that promote cell survival and proliferation, in regulating CSC phenotypes. Moreover, using cell lines and patient-derived xenograft models, we showed that inhibition of YAP1 enhances the efficacy of conventional therapies by attenuating CSC stemness features. In this review, we summarize the therapeutic strategies for targeting CSCs in several cancers and discuss the potential and challenges of the approach.

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