Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation and cell survival pathways

IUBMB Life ◽  
2020 ◽  
Author(s):  
Xiangqi Fan ◽  
Xiangjun Xiao ◽  
Xiangbing Mao ◽  
Daiwen Chen ◽  
Bing Yu ◽  
...  
Keyword(s):  
Cell Survival ◽  
Bioactive Components ◽  
Survival Pathways ◽  
Anti Inflammation

scholarly journals WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death

2010 ◽  
Vol 22 (5) ◽  
pp. 809-820 ◽  
Author(s):  
Balachandar Venkatesan ◽  
Sumanth D. Prabhu ◽  
Kaliyamurthi Venkatachalam ◽  
Srinivas Mummidi ◽  
Anthony J. Valente ◽  
...  
Keyword(s):  
Cell Survival ◽  
Signaling Pathway ◽  
Survival Pathways

Effect of 2-Hydroxyethyl Methacrylate on Human Pulp Cell Survival Pathways ERK and AKT

2008 ◽  
Vol 34 (6) ◽  
pp. 684-688 ◽  
Author(s):  
Gianrico Spagnuolo ◽  
Vincenzo D'Antò ◽  
Rosa Valletta ◽  
Caterina Strisciuglio ◽  
Gottfried Schmalz ◽  
...  
Keyword(s):  
Cell Survival ◽  
Hydroxyethyl Methacrylate ◽  
Pulp Cell ◽  
Survival Pathways

scholarly journals mTOR Signaling in the Inner Ear as Potential Target to Treat Hearing Loss

2021 ◽  
Vol 22 (12) ◽  
pp. 6368
Author(s):  
Maurizio Cortada ◽  
Soledad Levano ◽  
Daniel Bodmer
Keyword(s):  
Hearing Loss ◽  
Cell Survival ◽  
Inner Ear ◽  
Hearing Aids ◽  
Noise Exposure ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Signaling ◽  
Curative Therapy ◽  
Age Related ◽  
Survival Pathways

Hearing loss affects many people worldwide and occurs often as a result of age, ototoxic drugs and/or excessive noise exposure. With a growing number of elderly people, the number of people suffering from hearing loss will also increase in the future. Despite the high number of affected people, for most patients there is no curative therapy for hearing loss and hearing aids or cochlea implants remain the only option. Important treatment approaches for hearing loss include the development of regenerative therapies or the inhibition of cell death/promotion of cell survival pathways. The mammalian target of rapamycin (mTOR) pathway is a central regulator of cell growth, is involved in cell survival, and has been shown to be implicated in many age-related diseases. In the inner ear, mTOR signaling has also started to gain attention recently. In this review, we will emphasize recent discoveries of mTOR signaling in the inner ear and discuss implications for possible treatments for hearing restoration.

scholarly journals Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

2005 ◽  
Vol 171 (1) ◽  
pp. 87-98 ◽  
Author(s):  
W. Haung Yu ◽  
Ana Maria Cuervo ◽  
Asok Kumar ◽  
Corrinne M. Peterhoff ◽  
Stephen D. Schmidt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Survival ◽  
Mammalian Target Of Rapamycin ◽  
Amyloid Peptide ◽  
Survival Pathways ◽  
Secretase Activity ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In this study, we show that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β-amyloidosis. Subsequently, autophagosomes and late autophagic vacuoles (AVs) accumulate markedly in dystrophic dendrites, implying an impaired maturation of AVs to lysosomes. Immunolabeling identifies AVs in the brain as a major reservoir of intracellular Aβ. Purified AVs contain APP and β-cleaved APP and are highly enriched in PS1, nicastrin, and PS-dependent γ-secretase activity. Inducing or inhibiting macroautophagy in neuronal and nonneuronal cells by modulating mammalian target of rapamycin kinase elicits parallel changes in AV proliferation and Aβ production. Our results, therefore, link β-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD.

scholarly journals Propolis Augments Apoptosis Induced by Butyrate via Targeting Cell Survival Pathways

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73151 ◽  
Author(s):  
Eric Drago ◽  
Michael Bordonaro ◽  
Seon Lee ◽  
Wafa Atamna ◽  
Darina L. Lazarova
Keyword(s):  
Cell Survival ◽  
Survival Pathways

scholarly journals Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ian T. Saunders ◽  
Hina Mir ◽  
Neeraj Kapur ◽  
Shailesh Singh
Keyword(s):  
Colon Cancer ◽  
Cell Survival ◽  
Survival Pathways
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