Hsp70 inhibitors: Implications for the treatment of colorectal cancer

IUBMB Life ◽  
2019 ◽  
Vol 71 (12) ◽  
pp. 1834-1845
Author(s):  
Reyhaneh Moradi‐Marjaneh ◽  
Maryam Paseban ◽  
Mahdi Moradi Marjaneh
Keyword(s):  
Colorectal Cancer ◽  
Hsp70 Inhibitors

Therapeutic potency of heat-shock protein-70 in the pathogenesis of colorectal cancer: current status and perspectives

2019 ◽  
Vol 97 (2) ◽  
pp. 85-90 ◽  
Author(s):  
Atena Soleimani ◽  
Elnaz Zahiri ◽  
Sajad Ehtiati ◽  
Mahtab Norouzi ◽  
Farzad Rahmani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Current Status ◽  
Cancer Cell Proliferation ◽  
Client Proteins ◽  
Or Gene ◽  
Novel Strategy ◽  
Hsp70 Inhibitors

Heat-shock protein-70 (HSP70) is critical to the folding, stability, and activity of several client proteins including many responsible for cancer cell proliferation, apoptosis, drug toxicity, and metastasis. Up-regulation of HSP70 is positively associated with increased tumorigenicity as well as poor survival in colon cancer patients, supporting the diagnostic, prognostic, and therapeutic potencies of HSP70 in colorectal cancer. The administration of specific pharmacological inhibitors or gene knock-down for HSP70 suppresses tumor progression and enhances tumor cell chemosensitivity. This review summarizes the different tumorigenic properties of HSP70 and the potential therapeutic potency of HSP70 inhibitors in terms of a novel strategy for colorectal cancer therapy, for a better understanding, and hence better management of this disease.

Deletion mapping on chromosome 6 in colorectal cancer associated with ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A121-A122
Author(s):  
T EZAKI ◽  
M WATANABE ◽  
S FUNAKOSHI ◽  
M NAGANUMA ◽  
T AZUMA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Deletion Mapping ◽  
Chromosome 6

Predicting adherence to colorectal cancer surveillance after plypectomy

2001 ◽  
Vol 120 (5) ◽  
pp. A602-A602
Author(s):  
S RAWL ◽  
S BLACKBURN ◽  
L HACKWARD ◽  
N FINEBERG ◽  
T IMPERIALE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Surveillance ◽  
Colorectal Cancer Surveillance

Urokinase type plasminogen activator and inhibitor type-1 plasma levels in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A600 ◽  
Author(s):  
L HERSZENYI ◽  
F FARINATI ◽  
G ISTVAN ◽  
M PAOLI ◽  
G ROVERONI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Inhibitor Type

A panel of mono- and dinucleotide microsatellite markers is required for reliable determination of the MSI status in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A599
Author(s):  
C ARNOLD ◽  
A GOEL ◽  
J CARETHERS ◽  
L WASSERMAN ◽  
C COMPTON ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Markers ◽  
Reliable Determination

Use of plasma MMP-2 to measure response to surgery and chemoradiotherapy in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A159-A159
Author(s):  
M TUTTON ◽  
M GEORGE ◽  
S ECCLES ◽  
I SWIFT ◽  
M ABULAFI
Keyword(s):  
Colorectal Cancer

Barriers to colorectal cancer (CRS) screening in minority communities: inadequate knowledge of guidelines by physicians in training

2001 ◽  
Vol 120 (5) ◽  
pp. A604-A604
Author(s):  
M GENNARELLI ◽  
L JANDORF ◽  
C CROMWELL ◽  
H VALDIMARSDOTTIR ◽  
W REDD ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Minority Communities ◽  
Inadequate Knowledge

Changes in the CEA gene are a basis for the lack of hepatic metastases in a spontaneous colorectal cancer primate model

2001 ◽  
Vol 120 (5) ◽  
pp. A167-A167
Author(s):  
R ZIMMER ◽  
P THOMAS ◽  
N CLAPP ◽  
C STANNERS ◽  
M TOBI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hepatic Metastases ◽  
Primate Model ◽  
Cea Gene
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