Metabolomic profiling of blood plasma in patients with primary brain tumours: Basal plasma metabolites correlated with tumour grade and plasma biomarker analysis predicts feasibility of the successful statistical discrimination from healthy subjects – a preliminary study

IUBMB Life ◽  
2019 ◽  
Vol 71 (12) ◽  
pp. 1994-2002 ◽  
Author(s):  
Eva Baranovičová ◽  
Tomáš Galanda ◽  
Miroslav Galanda ◽  
Jozef Hatok ◽  
Branislav Kolarovszki ◽  
...  
Keyword(s):  
Brain Tumours ◽  
Healthy Subjects ◽  
Plasma Metabolites ◽  
Tumour Grade ◽  
Plasma Biomarker ◽  
Primary Brain Tumours ◽  
Metabolomic Profiling ◽  
Biomarker Analysis ◽  
Basal Plasma ◽  
Preliminary Study

Over-All Accuracy of 99mTc-Pertechnetate Brain Scanning for Brain Tumours – Study of 471 Patients

1978 ◽  
Vol 17 (06) ◽  
pp. 249-253
Author(s):  
E. Pétursson ◽  
B. Sigurbjörnsson ◽  
D. Davidsson ◽  
O.G. Björnsson
Keyword(s):  
Brain Metastases ◽  
Brain Tumours ◽  
True Negative ◽  
Diagnostic Reliability ◽  
Radioisotope Scanning ◽  
Primary Brain Tumours ◽  
99Mtc Pertechnetate

A 3-year follow-up and re-evaluation of all scans on all patients referred for brain scanning in Iceland during 1 year was performed in order to assess the diagnostic reliability of radioisotope scanning for brain tumours. The study included 471 patients. Of these 25 had primary brain tumours and 7 brain metastases. Scans were positive and correctly interpreted in68 % of the patients with primary brain tumours and in 3 of the 7 patients with metastases. The over-all accuracy of brain scanning for brain tumours defined as the total number of correct positive scans and correct negative scans versus total number of scans examined was 96%, this figure being mainly influenced by the high number of true negative scans.

scholarly journals Mortality due to primary brain tumours in China and detection rate in people with suspected symptoms: a nationally representative cross-sectional survey

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bin Jiang ◽  
Hongmei Liu ◽  
Dongling Sun ◽  
Haixin Sun ◽  
Xiaojuan Ru ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Detection Rate ◽  
Epidemiological Data ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Detection Rates ◽  
Primary Brain Tumours ◽  
Symptom Screening ◽  
Nationally Representative

Abstract Background and purpose Epidemiological data on primary brain tumours (PBTs) are lacking due to the difficulty in case ascertainment among the population. Thus, we aimed to estimate mortality due to PBTs in China nationwide and the detection rate in people with suspected symptoms. Methods A multistage, complex sampling survey regarding mortality due to PBTs in Chinese individuals was carried out by reviewing all causes of death within a year. The detection rates in people with suspected symptoms were estimated based on PBT symptom screening and neurologist reviews and compared between groups by logistic regression analysis. Results Weighted mortality due to PBT was 1.6 (0.8–3.3) per 100,000 population in Chinese individuals, 1.8 (0.7–4.6) per 100,000 population in men, and 1.5 (0.5–4.5) per 100,000 population in women. Among 14,990 people with suspected symptoms, the PBT detection rate was 306.9 (95% CI 224.7–409.3) per 100,000 population in the total population, 233.0 (95% CI 135.7–373.1) per 100,000 population in men, and 376.9 (95% CI 252.4–546.3) per 100,000 population in women. People with an unsteady gait (OR 2.46; 95% CI 1.09–5.51; P=0.029), visual anomalies (3.84; 1.88–7.85; P<0.001), and headache (2.06; 1.10–3.86; P=0.023) were more likely to have a brain tumour than those without corresponding symptoms, while people with dizziness/vertigo were less likely to have a brain tumour than those without corresponding symptoms (0.45; 0.23–0.87; P=0.017). Conclusions Mortality due to PBT in China was low, with a nationwide estimate of 21,215 (10,427–43,165) deaths attributable to PBTs annually. However, the detection rate of PBTs can be greatly improved based on symptom screening in the population.

scholarly journals Metabolomic profiles of plasma and uterine luminal fluids from healthy and repeat breeder Holstein cows

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Natsumi Funeshima ◽  
Ryotaro Miura ◽  
Taiga Katoh ◽  
Hikari Yaginuma ◽  
Takeshi Kitou ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Plasma Metabolites ◽  
Dependent Manner ◽  
Interferon Tau ◽  
Peripheral Blood Mononuclear ◽  
Metabolomic Profiling ◽  
Reproductive Disorder ◽  
Uterine Fluid ◽  
Reduced Rate ◽  
Repeat Breeder

Abstract Background Repeat breeding is a critical reproductive disorder in cattle. The problem of repeat breeder cattle remains largely unmanageable due to a lack of informative biomarkers. Here, we utilized metabolomic profiling in an attempt to identify metabolites in the blood plasma and uterine luminal fluids. We collected blood and uterine fluid from repeat breeder and healthy cows on day 7 of the estrous cycle. Results Metabolomic analysis identified 17 plasma metabolites detected at concentrations that distinguished between the two groups, including decreased various bile acids among the repeat breeders. However, no metabolites that varied significantly were detected in the uterine luminal fluids between two groups. Among the plasma samples, kynurenine was identified as undergoing the most significant variation. Kynurenine is a metabolite produced from tryptophan via the actions of indoleamine 2,3-dioxygenase (IDO). As IDO is key for maternal immune tolerance and induced in response to interferon tau (IFNT, ruminant maternal recognition of pregnancy factor), we examined the responsiveness to IFNT on peripheral blood mononuclear cells (PBMC) isolated from healthy and repeat breeder cows. The mRNA expression of IFNT-response makers (ISG15 and MX2) were significantly increased by IFNT treatment in a dose-dependent manner in both groups. Although treatment with IFNT promoted the expression of IDO in PBMCs from both groups, it did so at a substantially reduced rate among the repeat breeder cows, suggesting that decreased levels of kynurenine may relate to the reduced IDO expression in repeat breeder cows. Conclusions These findings provide valuable information towards the identification of critical biomarkers for repeat breeding syndrome in cattle.

scholarly journals Can National Tests from the Last Year of Compulsory School Be Used to Obtain More Detailed Information about Academic Performance in Children Treated for Brain Tumours? A Nationwide, Population-Based Study from Sweden

Cancers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 135
Author(s):  
Malin Lönnerblad ◽  
Eva Berglund ◽  
Ingrid van’t Hooft ◽  
Klas Blomgren
Keyword(s):  
Academic Performance ◽  
Oral Reading ◽  
Brain Tumours ◽  
Mother Tongue ◽  
Strong Predictor ◽  
Population Based ◽  
Late Complications ◽  
Age At Diagnosis ◽  
Tumour Grade ◽  
National Tests

Children treated for brain tumours often have late-appearing complications that may affect their school performance. Uneven skill profiles may help reveal late complications that can be compensated for but otherwise remain undetected. We investigated Swedish national school tests of oral, reading and writing skills in the first foreign language (English), the mother tongue (Swedish) and mathematics. Data were obtained from The Swedish Childhood Cancer Registry and Statistics Sweden. The results from 475 children diagnosed with a brain tumour before their 15th birthday and 2197 matched controls showed that children treated for brain tumours evinced more difficulties with national tests than controls in almost all subtests, especially in the subject English, and that they may perform better on oral than written tasks. There were larger differences between female cases and controls than between male cases and controls; age at diagnosis played a significant role for some subtests, whereas tumour grade did not. Missing information from national tests proved to be a strong predictor of poor academic performance. Our results show that regular educational follow-ups, as a complement to neuropsychological follow-ups, are important for all children treated for brain tumours, regardless of sex, age at diagnosis or tumour grade.

Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

1987 ◽  
Vol 48 (4) ◽  
pp. 501-504 ◽  
Author(s):  
C. Doutremepuich ◽  
D. Pailley ◽  
M.C. Anne ◽  
O. de Séze ◽  
J. Paccalin ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Healthy Subjects ◽  
Bleeding Time ◽  
Acetyl Salicylic Acid ◽  
Preliminary Study

Patients with Primary Brain Tumours Have Elevated Serum Titres of Antibodies to the Myelin Glycolipid Sulphatide

2001 ◽  
Vol 45 (1) ◽  
pp. 38-42 ◽  
Author(s):  
C. Nygren ◽  
H. v. Holst ◽  
K. Ericson ◽  
P. Fredman
Keyword(s):  
Brain Tumours ◽  
Elevated Serum ◽  
Primary Brain Tumours

3524 POSTER Epidemiology of Primary Brain Tumours in Georgia – First-year Results of a Prospective Population-based Study

2011 ◽  
Vol 47 ◽  
pp. S253 ◽  
Author(s):  
T. Gigineishvili ◽  
N. Shengelia ◽  
S. Kartsivadze ◽  
G. Shalashvili ◽  
S. Tsiskaridze ◽  
...  
Keyword(s):  
Brain Tumours ◽  
Population Based ◽  
First Year ◽  
Population Based Study ◽  
Primary Brain Tumours
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