scholarly journals TERT promoter mutation in primary papillary thyroid carcinoma lesions predicts absent or lower 131 i uptake in metastases

IUBMB Life ◽  
2019 ◽  
Author(s):  
Zhaowei Meng ◽  
Michiko Matsuse ◽  
Vladimir Saenko ◽  
Shunichi Yamashita ◽  
Peng Ren ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tert Promoter Mutation ◽  
Papillary Thyroid ◽  
Promoter Mutation ◽  
Tert Promoter

TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papillary Thyroid Carcinoma

2016 ◽  
Vol 28 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Eun Ji Oh ◽  
Sohee Lee ◽  
Ja Seong Bae ◽  
Yourha Kim ◽  
Sora Jeon ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tert Promoter Mutation ◽  
Papillary Thyroid ◽  
Promoter Mutation ◽  
Tert Promoter ◽  
Cribriform Morular Variant

scholarly journals TERT Promoter Mutation Spatial Heterogeneity in a Metastatic Follicular Thyroid Carcinoma: Implications for Clinical Work-Up

2019 ◽  
Vol 30 (3) ◽  
pp. 246-248 ◽  
Author(s):  
Adam Stenman ◽  
Martin Hysek ◽  
Kenbugul Jatta ◽  
Robert Bränström ◽  
Eva Darai-Ramqvist ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Spatial Heterogeneity ◽  
Follicular Thyroid Carcinoma ◽  
Clinical Work ◽  
Tert Promoter Mutation ◽  
Promoter Mutation ◽  
Tert Promoter ◽  
Work Up

scholarly journals A meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma

2017 ◽  
Vol 6 (3) ◽  
pp. R8-R17 ◽  
Author(s):  
Huy Gia Vuong ◽  
Uyen N P Duong ◽  
Ahmed M A Altibi ◽  
Hanh T T Ngo ◽  
Thong Quang Pham ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Random Effect ◽  
Random Effect Model ◽  
Disease Free Survival ◽  
Papillary Thyroid ◽  
Promoter Mutation ◽  
Meta Analyses ◽  
The Impact

The prognostic role of molecular markers in papillary thyroid carcinoma (PTC) is a matter of ongoing debate. The aim of our study is to investigate the impact of RAS, BRAF, TERT promoter mutations and RET/PTC rearrangements on the prognosis of PTC patients. We performed a search in four electronic databases: PubMed, Scopus, Web of Science and Virtual Health Library (VHL). Data of hazard ratio (HR) and its 95% confidence interval (CI) for disease-specific survival (DSS) and disease-free survival (DFS) were directly obtained from original papers or indirectly estimated from Kaplan–Meier curve (KMC). Pooled HRs were calculated using random-effect model weighted by inverse variance method. Publication bias was assessed by using Egger’s regression test and visual inspection of funnel plots. From 2630 studies, we finally included 35 studies with 17,732 patients for meta-analyses. TERT promoter mutation was significantly associated with unfavorable DSS (HR = 7.64; 95% CI = 4.00–14.61) and DFS (HR = 2.98; 95% CI = 2.27–3.92). BRAF mutations significantly increased the risk for recurrence (HR = 1.63; 95% CI = 1.27–2.10) but not for cancer mortality (HR = 1.41; 95% CI = 0.90–2.23). In subgroup analyses, BRAF mutation only showed its prognostic value in short-/medium-term follow-up. Data regarding RAS mutations and RET/PTC fusions were insufficient for meta-analyses. TERT promoter mutation can be used as an independent and reliable marker for risk stratification and predicting patient’s outcomes. The use of BRAF mutation to assess patient prognosis should be carefully considered.

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

2015 ◽  
Vol 33 (6) ◽  
pp. 667-668 ◽  
Author(s):  
Miguel Melo ◽  
Adriana Gaspar da Rocha ◽  
João Vinagre ◽  
Manuel Sobrinho-Simões ◽  
Paula Soares
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Added Value ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Tert Promoter ◽  
Patient Prognosis

Suspicious ultrasound and clinicopathological features of papillary thyroid carcinoma predict the status of TERT promoter

Endocrine ◽  
2020 ◽  
Vol 68 (2) ◽  
pp. 349-357
Author(s):  
Hui Shi ◽  
Le-Hang Guo ◽  
Yi-Feng Zhang ◽  
Hui-Jun Fu ◽  
Jia-Yi Zheng ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Tert Promoter ◽  
The Status
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