scholarly journals Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease

IUBMB Life ◽  
2018 ◽  
Vol 71 (2) ◽  
pp. 277-282 ◽  
Author(s):  
Qiang Zhang ◽  
Yongshun Ai ◽  
Huiqiu Dong ◽  
Junsong Wang ◽  
Li Xu
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Early Stage ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Strong Risk Factor

Identification of oxidized low-density lipoprotein in human serum by NMR spectroscopy

1998 ◽  
Vol 95 (4) ◽  
pp. 489-495 ◽  
Author(s):  
J. JANKOWSKI ◽  
J.-R. NOFER ◽  
M. TEPEL ◽  
B. GRIEWEL ◽  
H. SCHLÜTER ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Human Serum ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Simple Method ◽  
Control Subjects ◽  
Healthy Control

1.In this study we compared the 500 MHz 1H-NMRs from native and oxidized low-density lipoproteins. 2.The measurements revealed a characteristic pattern of three resonances in spectra from oxidized, but not from native low-density liprotein at 1.17 p.p.m., 1.18 p.p.m. and 1.20 p.p.m. (relative to 3-trimethylsilyl-[2,2,3,3-2H4]-propionate). 3.A quantitative comparison between these resonances in sera from patients with coronary heart disease and healthy control subjects revealed that the intensity was significantly higher in patients with coronary heart disease (1.17 p.p.m.: 0.026±0.014 versus 0.015±0.019; 1.18 p.p.m.: 0.032±0.011 versus 0.017±0.021; 1.20 p.p.m.: 0.030±0.066 versus 0.010±0.005; P< 0.05 compared with healthy control subjects for each resonance). 4.Fractionation of sera from patients with coronary heart disease revealed that the resonances equal to those obtained from experimentally oxidized low-density lipoprotein are indeed caused by the low-density lipoprotein fraction of the sera. 5.When the NMRs from sera were calibrated with oxidized low-density lipoprotein prepared by Cu2+ oxidation, a concentration of 66.5±28.6 ;μg/ml and 36.3±23.7 ;μg/ml (P< 0.05) was estimated in patients with coronary heart disease and healthy subjects respectively. Elevated levels of oxidized low-density lipoprotein also occurred in those patients with normal serum concentrations of total low-density lipoprotein. 6.The study shows a simple method to measure oxidized low-density lipoprotein in human serum and may gain interest to assess the cardiovascular risk factor profiles more completely.

scholarly journals Autoantibodies Against Oxidized Low-Density Lipoprotein and Cardiolipin in Patients With Coronary Heart Disease

2000 ◽  
Vol 20 (1) ◽  
pp. 204-209 ◽  
Author(s):  
Arja T. Erkkilä ◽  
Outi Närvänen ◽  
Seppo Lehto ◽  
Matti I. J. Uusitupa ◽  
Seppo Ylä-Herttuala
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein
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