scholarly journals A genetic variant in a homocysteine metabolic gene that increases the risk of congenital cardiac septal defects in Han Chinese populations

IUBMB Life ◽  
2017 ◽  
Vol 69 (9) ◽  
pp. 700-705
Author(s):  
Han-Hui Xie ◽  
Jiong Li ◽  
Pei-Qiang Li ◽  
An-An Zhang ◽  
Yi Li ◽  
...  
Keyword(s):  
Genetic Variant ◽  
Han Chinese ◽  
Metabolic Gene ◽  
Chinese Populations ◽  
Septal Defects ◽  
Cardiac Septal Defects

scholarly journals A Genetic Variant in Vitamin B12 Metabolic Genes That Reduces the Risk of Congenital Heart Disease in Han Chinese Populations

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88332 ◽  
Author(s):  
Jue Wang ◽  
Jian-Yuan Zhao ◽  
Feng Wang ◽  
Qian-Qian Peng ◽  
Jia Hou ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Vitamin B12 ◽  
Congenital Heart ◽  
Genetic Variant ◽  
Han Chinese ◽  
Chinese Populations ◽  
Metabolic Genes

A Genetic Variant in FIGN Gene Reduces the Risk of Congenital Heart Disease in Han Chinese Populations

2017 ◽  
Vol 38 (6) ◽  
pp. 1169-1174 ◽  
Author(s):  
Dan Wang ◽  
Maoping Chu ◽  
Feng Wang ◽  
Aihua Zhou ◽  
Miaohua Ruan ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Genetic Variant ◽  
Han Chinese ◽  
Chinese Populations

scholarly journals Genetic Polymorphisms of the TYMS Gene Are Not Associated with Congenital Cardiac Septal Defects in a Han Chinese Population

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31644 ◽  
Author(s):  
Jian-Yuan Zhao ◽  
Jing-Wei Sun ◽  
Zhuo-Ya Gu ◽  
Jue Wang ◽  
Er-Li Wang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Septal Defects ◽  
Cardiac Septal Defects

scholarly journals Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

2009 ◽  
Vol 18 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Yang Li ◽  
Wen-Jing Wang ◽  
Huiqing Cao ◽  
Jiehua Lu ◽  
Chong Wu ◽  
...  
Keyword(s):  
Genetic Association ◽  
Han Chinese ◽  
Chinese Populations

Abstract TP134: Genome Wide Association Studies in Han Chinese Populations Identify Novel Susceptibility Loci for Specific Ischemic Stroke Subtypes

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Tai-Ming Ko ◽  
Tsong-Hai Lee Lee ◽  
Chien-Hsiun Chen ◽  
Yuan-Tsong Chen ◽  
Jer-Yuarn Wu
Keyword(s):  
Ischemic Stroke ◽  
Chinese Population ◽  
Genetic Factors ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Papillary Thyroid ◽  
Susceptibility Loci ◽  
Han Chinese Population ◽  
Chinese Populations ◽  
Genome Wide

Introduction: Although family history studies in ischemic stroke support that genetic factors may be involved in the pathogenesis of two major subtypes of ischemia stroke: large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO), it is still unclear which particular genetic factors contribute to LAA or SVO. Hypothesis: Because the etiology of ischemic stroke is heterogeneous, we hypothesize that genetic factors may vary by etiologic subtypes or ethnicities. Thus, we aim to identify genetic factors that contribute to LAA or SVO based on two independent Han Chinese populations. Methods: Novel genetic variants that predispose individuals to LAA and SVO were identified by genome-wide association study comprising of 824 individuals (including 444 LAA cases and 380 SVO cases) and 1,727 controls in a Han Chinese population residing in Taiwan. The LAA study was replicated in an independent Han Chinese population comprising of an additional 319 LAA cases and 1,802 controls. Results: In LAA cases, from two independent populations, we identified five single-nucleotide polymorphisms (SNPs), including SNP-1 (P = 3.10 х 10–8), SNP-2 (P = 4.00 х 10–9), SNP-3 (P = 3.57 х 10–8), SNP-4 (P = 1.76 х 10–8), and SNP-5 (P = 2.92 х 10–8), at one novel locus on chromosome 14q13.3 within PTCSC3 (encoding papillary thyroid carcinoma susceptibility candidate 3). In SVO cases, from the discovery stage, we identified two novel candidate susceptibility loci on chromosome 3p25.3 (SNP-6, P = 3.24 х 10–5) and chromosome 14 q31.1 (SNP-7, P = 2.58 х 10–4). Conclusions: For LAA, the newly identified SNPs within PTCSC3 gene were found to have genome-wide statistical significance (P < 5 х 10–8) and were shown to be located in a risk locus correlated with papillary thyroid carcinoma. Moreover, the genetic association between PTCSC3 gene and SVO was not identified, which suggested that PTCSC3 is a specific susceptibility locus for LAA. For SVO, we identified two novel candidate genetic loci which were valuable for replication by an independent population with SVO. In conclusion, our findings provide insights into the genetic basis of LAA and SVO, which may be applicable in the study of the pathogenesis of ischemic stroke and in the development of alternative therapeutic interventions.

PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis

2013 ◽  
Vol 34 (7) ◽  
pp. 1922.e1-1922.e5 ◽  
Author(s):  
YongPing Chen ◽  
Zhen-Zhen zheng ◽  
Rui Huang ◽  
Ke Chen ◽  
Wei Song ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Han Chinese ◽  
Chinese Populations ◽  
Lateral Sclerosis
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