scholarly journals Apolipoprotein E isoforms and lipoprotein metabolism

IUBMB Life ◽  
2014 ◽  
Vol 66 (9) ◽  
pp. 616-623 ◽  
Author(s):  
Michael C. Phillips
Keyword(s):  
Apolipoprotein E ◽  
Lipoprotein Metabolism

scholarly journals Role of Apolipoprotein E in Lipoprotein Metabolism and in the Process of Atherosclerosis

1995 ◽  
Vol 2 (Supplement1) ◽  
pp. S29-S33 ◽  
Author(s):  
Nobuhiro Yamada ◽  
Hitoshi Shimano ◽  
Yoshio Yazaki
Keyword(s):  
Apolipoprotein E ◽  
Lipoprotein Metabolism

scholarly journals Pinus pinaster Oil Affects Lipoprotein Metabolism in Apolipoprotein E-Deficient Mice

1999 ◽  
Vol 129 (11) ◽  
pp. 1972-1978 ◽  
Author(s):  
G. Asset ◽  
E. Baugé ◽  
R. L. Wolff ◽  
J. C. Fruchart ◽  
J. Dallongeville
Keyword(s):  
Apolipoprotein E ◽  
Pinus Pinaster ◽  
Lipoprotein Metabolism ◽  
Deficient Mice

Role of apolipoprotein E in lipoprotein metabolism

1987 ◽  
Vol 113 (2) ◽  
pp. 470-474 ◽  
Author(s):  
Richard J. Havel ◽  
Nobuhiro Yamada ◽  
David M. Shames
Keyword(s):  
Apolipoprotein E ◽  
Lipoprotein Metabolism

scholarly journals PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: Evidence for genotype-specific regulation of lipoprotein metabolism

2015 ◽  
Vol 62 (4) ◽  
pp. 763-770 ◽  
Author(s):  
Simon H. Bridge ◽  
David A. Sheridan ◽  
Daniel J. Felmlee ◽  
Mary M.E. Crossey ◽  
Fiona I. Fenwick ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Apolipoprotein E ◽  
Chronic Hepatitis C ◽  
Lipoprotein Metabolism ◽  
Genotype 3 ◽  
Specific Regulation

Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation

Blood ◽  
2003 ◽  
Vol 101 (10) ◽  
pp. 3901-3907 ◽  
Author(s):  
Hong Wang ◽  
XiaoHua Jiang ◽  
Fan Yang ◽  
John W. Gaubatz ◽  
Lang Ma ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Low Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Peritoneal Macrophages ◽  
Direct Role ◽  
Knock Out ◽  
Knock Out Mice ◽  
Mouse Peritoneal Macrophages

AbstractAlthough hyperhomocysteinemia is an independent risk factor for cardiovascular disease, a direct role for homocysteine (Hcy) in this disease remains to be shown. Whereas diet-induced hyperhomocysteinemia promotes atherosclerosis in animal models, the effects of Hcy on atherogenesis in the absence of dietary perturbations is not known. We have generated double knock-out mice with targeted deletions of the genes for apolipoprotein E (apoE) and cystathionine β-synthase (CBS), which converts Hcy to cystathionine. ApoE−/−/CBS−/− mice developed aortic lesions even in the absence of dietary manipulation; lesion area and lesion cholesteryl ester (CE) and triglyceride (TG) contents increased with animal age and plasma Hcy levels. Plasma total cholesterol was significantly increased, whereas high density lipoprotein (HDL) cholesterol and TG concentrations of apoE−/−/CBS−/− mice were decreased. Cholesterol esterification and activities of enzymes catalyzing CE or TG formation in the vessel wall and in peritoneal macrophages were not changed by hyperhomocysteinemia. However, uptake of human acetyl-LDL, but not native low density lipoprotein (LDL), by mouse peritoneal macrophages was higher in the presence of hyperhomocysteinemia. These results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic and macrophage lipoprotein metabolism, in part, by enhancing uptake of modified LDL.

Low- and High-Density Lipoprotein Metabolism in HepG2 Cells Expressing Various Levels of Apolipoprotein E†

Biochemistry ◽  
2000 ◽  
Vol 39 (51) ◽  
pp. 16084-16091 ◽  
Author(s):  
Daniel Charpentier ◽  
Caroline Tremblay ◽  
Eric Rassart ◽  
David Rhainds ◽  
Anick Auger ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Apolipoprotein E ◽  
Hepg2 Cells ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
High Density
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