scholarly journals Homer Proteins in Ca2+Entry

IUBMB Life ◽  
2013 ◽  
Vol 65 (6) ◽  
pp. 497-504 ◽  
Author(s):  
Isaac Jardin ◽  
José J. López ◽  
Alejandro Berna-Erro ◽  
Ginés M. Salido ◽  
Juan A. Rosado
Keyword(s):  
Homer Proteins

Homer proteins: implications for neuropsychiatric disorders

2006 ◽  
Vol 16 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Karen K Szumlinski ◽  
Peter W Kalivas ◽  
Paul F Worley
Keyword(s):  
Neuropsychiatric Disorders ◽  
Homer Proteins

scholarly journals Mouse brain and muscle tissues constitutively express high levels of Homer proteins

2000 ◽  
Vol 267 (3) ◽  
pp. 634-639 ◽  
Author(s):  
Mikhail M. Soloviev ◽  
Francisco Ciruela ◽  
Wai-Yee Chan ◽  
R. A. Jeffrey McIlhinney
Keyword(s):  
Mouse Brain ◽  
Muscle Tissues ◽  
Homer Proteins

scholarly journals Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila

SLEEP ◽  
2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Sarah Ly ◽  
Ewa Strus ◽  
Nirinjini Naidoo
Keyword(s):  
Binding Site ◽  
Metabotropic Glutamate Receptors ◽  
Amino Acid Replacement ◽  
Sleep Regulation ◽  
Metabotropic Glutamate ◽  
Functional Homology ◽  
Group I ◽  
Homer Proteins ◽  
Physical Dissociation ◽  
Putative Binding Site

Abstract Homer proteins mediate plasticity and signaling at the postsynaptic density of neurons and are necessary for sleep and synaptic remodeling during sleep. The goal of this study was to investigate the mechanisms of sleep regulation by Homer signaling. Using the Drosophila animal model, we demonstrate that knockdown of Homer specifically in the brain reduces sleep and that Drosophila Homer binds to the sole Drosophila mGluR, known as DmGluRA. This is the first evidence that DmGluRA, which bears greatest homology to group II mammalian metabotropic glutamate receptors (mGluRs), shares functional homology with group I mGluRs which couple to Homer proteins in mammals. As sleep is associated with the physical dissociation of Homer and mGluRs proteins at the synapse, we sought to determine the functional necessity of Homer × DmGluRA interaction in sleep regulation. Using the CRISPR/Cas9 gene editing system, we generated a targeted amino acid replacement of the putative binding site for Homer on DmGluRA to prevent Homer and DmGluRA protein binding. We found that loss of the conserved proline-rich PPXXF sequence on DmGluRA reduces Homer/DmGluRA associations and significantly reduces sleep amount. Thus, we identify a conserved mechanism of synaptic plasticity in Drosophila and demonstrate that the interaction of Homer with DmGluRA is necessary to promote sleep.

Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling

Cell Calcium ◽  
2003 ◽  
Vol 34 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Jens H Westhoff ◽  
Sung-Yong Hwang ◽  
R Scott Duncan ◽  
Fumiko Ozawa ◽  
Pompeo Volpe ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Intracellular Calcium ◽  
Ryanodine Receptor ◽  
Receptor Type ◽  
Intracellular Calcium Signaling ◽  
Homer Proteins

scholarly journals Homer Proteins Regulate Sensitivity to Cocaine

Neuron ◽  
2004 ◽  
Vol 43 (3) ◽  
pp. 401-413 ◽  
Author(s):  
Karen K. Szumlinski ◽  
Marlin H. Dehoff ◽  
Shin H. Kang ◽  
Kelly A. Frys ◽  
Kevin D. Lominac ◽  
...  
Keyword(s):  
Homer Proteins

Control of constitutive activity of metabotropic glutamate receptors by Homer proteins

2003 ◽  
Vol 1249 ◽  
pp. 245-251 ◽  
Author(s):  
Laurent Fagni ◽  
Fabrice Ango ◽  
Laurent Prezeau ◽  
Paul F. Worley ◽  
Jean-Philippe Pin ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Constitutive Activity ◽  
Metabotropic Glutamate ◽  
Homer Proteins

scholarly journals Changes in mGlu5 Receptor-Dependent Synaptic Plasticity and Coupling to Homer Proteins in the Hippocampus of Ube3A Hemizygous Mice Modeling Angelman Syndrome

2014 ◽  
Vol 34 (13) ◽  
pp. 4558-4566 ◽  
Author(s):  
M. Pignatelli ◽  
S. Piccinin ◽  
G. Molinaro ◽  
L. Di Menna ◽  
B. Riozzi ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Angelman Syndrome ◽  
Mglu5 Receptor ◽  
Homer Proteins
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