Evaluation of early relational disturbance in high‐risk populations: Borderline personality disorder features, maternal mental state, and observed interaction

2020 ◽  
Vol 41 (6) ◽  
pp. 793-810
Author(s):  
Vesna Newman‐Morris ◽  
Katrina Simpson ◽  
Kylie M. Gray ◽  
Natasha Perry ◽  
Adrian Dunlop ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Mental State ◽  
Borderline Personality ◽  
High Risk Populations

scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

2020 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Childhood Maltreatment ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Antisocial Personality ◽  
Male Inmates

Abstract Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder among Male Inmates in China

2019 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Physical Abuse ◽  
Childhood Maltreatment ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Genotype Frequency ◽  
Male Inmates

Abstract Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates with high risk were included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals Metaphors in Mentalization-Based Treatment: Reintroducing the Language of Change in “Plain Old Therapy”

2021 ◽  
Author(s):  
E. J. Folmo ◽  
T. Langjord ◽  
N. C. S. Myhrvold ◽  
M. Lind
Keyword(s):  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Social Trust ◽  
Borderline Personality ◽  
Evidence Based ◽  
Cognitive Content ◽  
Perennial Philosophy ◽  
Evidence Based Treatments

AbstractMetaphors, a central conduit of change in psychotherapy, have not been taken adequately into account in Mentalization-Based Treatment (MBT). Despite successfully utilized by other evidence-based treatments for borderline personality disorder (BPD), MBT considers metaphors confusing for patients with low mentalizing abilities. For metaphors and teaching stories to stimulate growth within the window of tolerance, interventions should be responsively tailored (e.g., explained). Metaphors might be a route to making spoken matter more apprehensible, and bridge emotions with cognitive content. They hold the potential for challenging without being too confronting, and to translate knowledge between different range of understanding. This theoretical article presents why the use of metaphors in MBT—in the hands of a responsive therapists—may prove a powerful tool to open social trust, despite being considered a “high risk” intervention. The timeless lens of the metaphor may help us connect with archetypical versions of our own narratives, hence understanding our subjectivity in a larger perspective. By reaching towards concepts beyond our normal reasoning, typically denoted perennial philosophy or wisdom, they may substitute and/or supplement mentors in a memorable way.

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