scholarly journals Childhood maltreatment and prospectively observed quality of early care as predictors of antisocial personality disorder features

2012 ◽  
Vol 33 (1) ◽  
pp. 55-69 ◽  
Author(s):  
Zhenyu Shi ◽  
Jean-Francois Bureau ◽  
M. Ann Easterbrooks ◽  
Xudong Zhao ◽  
Karlen Lyons-Ruth
Keyword(s):  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Childhood Maltreatment ◽  
Antisocial Personality ◽  
Early Care

scholarly journals Oxytocin Receptor Gene, Childhood Maltreatment and Borderline Personality Disorder Features among Male Inmates in China

2020 ◽  
Author(s):  
Min Zhang ◽  
Na Liu ◽  
Haocheng Chen ◽  
Ning Zhang
Keyword(s):  
Sexual Abuse ◽  
Borderline Personality Disorder ◽  
High Risk ◽  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Childhood Maltreatment ◽  
Oxytocin Receptor ◽  
Borderline Personality ◽  
Antisocial Personality ◽  
Male Inmates

Abstract Background: Borderline personality disorder (BPD) is caused by a variety of biological and environmental factors. Accumulating evidence suggests that childhood maltreatment is a risk environmental factor in the development of BPD, but research on the genetic pathology of BPD is still in its early stages, and very little is known about the oxytocin receptor (OXTR) gene. The purpose of this study is to further explore the interactive effects between OXTR gene polymorphisms and childhood maltreatment on BPD risk. Methods: Among the 1804 male inmates, 765 inmates who had BPD or antisocial personality disorder (ASPD) or highly impulsive or violent crime were considered as high-risk inmates and included in this study. Childhood maltreatment, BPD, antisocial personality disorder (ASPD) and impulsivity were measured by self-reported questionnaires. Peripheral venous blood was collected for the genotype test. Results: Analyses revealed that the BP group (inmates with BPD features) had higher rs53576 AA genotype frequency and rs237987 AA genotype frequency than the non-BP group, while the statistical significances were lost after Bonferroni correction. Total childhood maltreatment score, emotional abuse and neglect could positively predict BPD risk. Among the high-risk samples, rs53576 GG genotype carriers had higher BPD scores at higher levels of physical abuse and sexual abuse and had lower BPD scores at lower levels of physical abuse and sexual abuse. Conclusions: The findings suggest that the interaction between OXTR gene variations and childhood maltreatment is an important mechanism for the development of BPD. The moderating role of the OXTR gene provides evidence for gene plasticity.

scholarly journals The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism

2018 ◽  
Vol 31 (1) ◽  
pp. 361-377 ◽  
Author(s):  
Amy L. Byrd ◽  
Stephen B. Manuck ◽  
Samuel W. Hawes ◽  
Tayler J. Vebares ◽  
Vishwajit Nimgaonkar ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Childhood Maltreatment ◽  
Emotional Reactivity ◽  
Borderline Personality ◽  
Monoamine Oxidase A ◽  
Personality Pathology ◽  
Antisocial Personality ◽  
Gene Environment

AbstractResearch consistently demonstrates that common polymorphic variation in monoamine oxidase A (MAOA) moderates the influence of childhood maltreatment on later antisocial behavior, with growing evidence that the “risk” allele (high vs. low activity) differs for females. However, little is known abouthowthis Gene × Environment interaction functions to increase risk, or if this risk pathway is specific to antisocial behavior. Using a prospectively assessed, longitudinal sample of females (n= 2,004), we examined whether changes in emotional reactivity (ER) during adolescence mediated associations between this Gene × Environment and antisocial personality disorder in early adulthood. In addition, we assessed whether this putative risk pathway also conferred risk for borderline personality disorder, a related disorder characterized by high ER. While direct associations between early maltreatment and later personality pathology did not vary by genotype, there was a significant difference in the indirect path via ER during adolescence. Consistent with hypotheses, females with high-activityMAOAgenotype who experienced early maltreatment had greater increases in ER during adolescence, and higher levels of ER predicted both antisocial personality disorderandborderline personality disorder symptom severity. Taken together, findings suggest that the interaction betweenMAOAand early maltreatment places women at risk for a broader range of personality pathology via effects on ER.

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