High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology

2020 ◽  
Vol 30 (2) ◽  
pp. 464-472
Author(s):  
Wenxue Zhang ◽  
Jianbo Jian ◽  
Cuiyun Sun ◽  
Jie Chen ◽  
Wenjuan Lv ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Phase Contrast ◽  
3D Imaging ◽  
Human Glioma ◽  
X Ray ◽  
Microvascular Architecture

scholarly journals Robust phase retrieval for high resolution edge illumination x-ray phase-contrast computed tomography in non-ideal environments

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anna Zamir ◽  
Marco Endrizzi ◽  
Charlotte K. Hagen ◽  
Fabio A. Vittoria ◽  
Luca Urbani ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Phase Contrast ◽  
Phase Retrieval ◽  
X Ray

scholarly journals Advances in 3D imaging and volumetric reconstruction of fluid and melt inclusions by high resolution X-ray computed tomography

2019 ◽  
Vol 508 ◽  
pp. 3-14 ◽  
Author(s):  
Antonin Richard ◽  
Christophe Morlot ◽  
Laura Créon ◽  
Nicolas Beaudoin ◽  
Vladimir S. Balistky ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
3D Imaging ◽  
Melt Inclusions ◽  
X Ray ◽  
Volumetric Reconstruction ◽  
Fluid And Melt Inclusions ◽  
X Ray Computed

X-ray computed tomography in Zernike phase contrast mode at 8 keV with 50-nm resolution using Cu rotating anode X-ray source

2007 ◽  
Vol 222 (11/2007) ◽  
Author(s):  
Andrei Tkachuk ◽  
Fred Duewer ◽  
Hongtao Cui ◽  
Michael Feser ◽  
Steve Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Phase Contrast ◽  
High Efficiency ◽  
Materials Science ◽  
Fresnel Zone ◽  
X Ray ◽  
X Ray Computed ◽  
Structure Height ◽  
Better Than

High-resolution X-ray computed tomography (XCT) enables nondestructive 3D imaging of complex structures, regardless of their state of crystallinity. This work describes a sub-50 nm resolution XCT system operating at 8 keV in absorption and Zernike phase contrast modes based on a commercially available Cu rotating anode laboratory X-ray source. The system utilizes a high efficiency reflective capillary condenser lens and high-resolution Fresnel zone plates with an outermost zone width of 35 nm and 700 nm structure height resulting in a spatial resolution better than 50 nm currently. Imaging a fragment of the solid oxide fuel cells (SOFC) with 50 nm resolution is presented as an application example of the XCT technique in materials science and nanotechnology.

Breast tumor segmentation in high resolution x-ray phase contrast analyzer based computed tomography

2014 ◽  
Vol 41 (11) ◽  
pp. 111902 ◽  
Author(s):  
E. Brun ◽  
S. Grandl ◽  
A. Sztrókay-Gaul ◽  
G. Barbone ◽  
A. Mittone ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Breast Tumor ◽  
Phase Contrast ◽  
Tumor Segmentation ◽  
X Ray

scholarly journals Visualization Ability of Phase-Contrast Synchrotron-Based X-Ray Imaging Using an X-Ray Interferometer in Soft Tissue Tumors

2021 ◽  
Vol 20 ◽  
pp. 153303382110101
Author(s):  
Thet-Thet Lwin ◽  
Akio Yoneyama ◽  
Hiroko Maruyama ◽  
Tohoru Takeda
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Spatial Resolution ◽  
Phase Contrast ◽  
Soft Tissue Tumors ◽  
X Ray ◽  
3 Dimensional ◽  
Computed Tomography Images ◽  
X Ray Imaging ◽  
X Ray Computed

Phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer provides high sensitivity and high spatial resolution, and it has the ability to depict the fine morphological structures of biological soft tissues, including tumors. In this study, we quantitatively compared phase-contrast synchrotron-based X-ray computed tomography images and images of histopathological hematoxylin-eosin-stained sections of spontaneously occurring rat testicular tumors that contained different types of cells. The absolute densities measured on the phase-contrast synchrotron-based X-ray computed tomography images correlated well with the densities of the nuclear chromatin in the histological images, thereby demonstrating the ability of phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer to reliably identify the characteristics of cancer cells within solid soft tissue tumors. In addition, 3-dimensional synchrotron-based phase-contrast X-ray computed tomography enables screening for different structures within tumors, such as solid, cystic, and fibrous tissues, and blood clots, from any direction and with a spatial resolution down to 26 μm. Thus, phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer shows potential for being useful in preclinical cancer research by providing the ability to depict the characteristics of tumor cells and by offering 3-dimensional information capabilities.

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