Olfactory identification and white matter integrity in amnestic mild cognitive impairment: A preliminary study

2016 ◽  
Vol 26 (4) ◽  
pp. 270-276
Author(s):  
Seon Young Ryu ◽  
Dong Chang Lee ◽  
Sang Bong Lee ◽  
Tae Woo Kim ◽  
Taek Jun Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Integrity ◽  
Olfactory Identification ◽  
Preliminary Study

P2-065: Volume loss and parahippocampal white matter integrity in amnestic mild cognitive impairment

2008 ◽  
Vol 4 ◽  
pp. T386-T386
Author(s):  
Emily J. Rogalski ◽  
Chris M. Murphy ◽  
Leyla de Toledo-Morrell ◽  
Raj C. Shah ◽  
Mehul A. Trivedi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Integrity ◽  
Volume Loss

scholarly journals Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages

2021 ◽  
Vol 15 ◽  
Author(s):  
Siyu Wang ◽  
Jiang Rao ◽  
Yingying Yue ◽  
Chen Xue ◽  
Guanjie Hu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Activation ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Integrity ◽  
Correlation Analyses ◽  
Preclinical Ad

BackgroundSubjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI) are regarded to be at high risk of converting to Alzheimer’s disease (AD). Amplitude of low-frequency fluctuations (ALFF) can reflect functional deterioration while diffusion tensor imaging (DTI) is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands and white matter fiber integrity among normal controls (CN), SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.ResultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus (LING) and superior frontal gyrus (SFG) within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus (UF) in aMCI patients and within the superior longitudinal fasciculus (SLF) in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.ConclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression.

P4-188: White Matter Integrity and Olfactory Function in Mild Cognitive Impairment: Preliminary Study

2016 ◽  
Vol 12 ◽  
pp. P1094-P1094
Author(s):  
Seon Young Ryu ◽  
Sang Bong Lee ◽  
Tae Woo Kim ◽  
Taek Jun Lee ◽  
Dong Chang Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Olfactory Function ◽  
White Matter Integrity ◽  
Preliminary Study
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