scholarly journals Editorial Comment to False‐positive 123 I‐metaiodobenzylguanidine scan in a patient with renal cell carcinoma: A case of chromophobe renal cell carcinoma oncocytic variant with a complicated clinical course

2020 ◽  
Vol 4 (1) ◽  
pp. 42-43
Author(s):  
Naoto Kuroda
Keyword(s):  
Renal Cell Carcinoma ◽  
Editorial Comment ◽  
Cell Carcinoma ◽  
False Positive ◽  
Renal Cell ◽  
Clinical Course ◽  
Chromophobe Renal Cell Carcinoma ◽  
Oncocytic Variant

scholarly journals Oncocytic variant, a novel subtype of chromophobe renal cell carcinoma: a report of two cases and a literature review

2020 ◽  
Author(s):  
Takashi Karashima ◽  
Naoto Kuroda ◽  
Takahiro Taguchi ◽  
Hideo Fukuhara ◽  
Takahira Kuno ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Staining ◽  
Histopathological Examination ◽  
Chromophobe Renal Cell Carcinoma ◽  
Rare Entity ◽  
Cytokeratin 7 ◽  
Novel Variant ◽  
Oncocytic Variant

AbstractA novel variant of chromophobe renal cell carcinoma showing an oncocytic phenotype is proposed. Two new cases of this rare entity are presented and discussed along with six previous cases from our colleagues. A 76-year-old man and a 78-year-old man had a 3.4-cm and a 3.2-cm-diameter renal mass, respectively. On histopathological examination of surgical specimens, uniform eosinophilic cuboidal cells without a perinuclear halo growing in a tubular pattern were seen, and differential diagnosis from oncocytoma was necessary. Immunohistochemical staining for cytokeratin 7 and E-cadherin showed diffusely positive patterns in both, as in the previous reports. Although monosomy of chromosomes 7, 10, 13, and 17 was commonly observed in the previous reports, gains of chromosome 19 were observed in the two present cases. Immunohistochemical and cytogenetic approaches lead to exclusion of oncocytoma and the diagnosis of an oncocytic variant of chromophobe renal cell carcinoma.

scholarly journals A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Noriyoshi Ishikawa ◽  
Nao Kimura ◽  
Toshio Yoshida ◽  
Ichiro Yoshimura ◽  
Ken Nakahara ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chromophobe Renal Cell Carcinoma ◽  
Low Grade ◽  
Diagnostic Challenge ◽  
Eosinophilic Cytoplasm ◽  
Oncocytic Tumor ◽  
Oncocytic Variant ◽  
Disease Entities

The oncocytic variant of chromophobe renal cell carcinoma (oChRCC) and low-grade oncocytic tumor (LOT) is introduced as new renal disease entity. Both of these tumors are low-grade malignancies consisting of cells with eosinophilic cytoplasm. Distinguishing between eosinophilic variant of chromophobe renal cell carcinoma (eCRCC) and oncocytoma is often a diagnostic challenge in routine surgical pathology. However, oChRCC and LOT might be independent disease entities that might not fit completely into any of these categories. Histologically, these tumors have greater morphological similarity with oncocytoma than with ChRCC. However, immunohistochemically, they exhibit diffuse and dense positivity for CK7 and are negative for CD117. In the present case, we initially had difficulty distinguishing among oncocytoma, eCRCC, and type 2 papillary renal cell carcinoma (2-pRCC). However, after learning about new disease entities such as oChRCC and LOT, we were able to diagnose this tumor.

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