Serum HE4 is associated with clinical prognostic factors and survival outcome in female patients with primary peritoneal carcinoma

BACKGROUND Perihilar cholangiocarcinoma (pCCA) is a highly aggressive malignancy with poor prognosis. Accurate prediction is of great significance for patients’ survival outcome. OBJECTIVE The present study aimed to propose a prognostic nomogram for predicting the overall survival (OS) for patients with pCCA. METHODS We conducted a retrospective analysis in a total of 940 patients enrolled from the Surveillance, Epidemiology, and End Results (SEER) program and developed a nomogram based on the prognostic factors identified from the cox regression analysis. Concordance index (C-index), risk group stratification and calibration curves were adopted to test the discrimination and calibration ability of the nomogram with bootstrap method. Decision curves were also plotted to evaluate net benefits in clinical use against TNM staging system. RESULTS On the basis of multivariate analysis, five independent prognostic factors including age, summary stage, surgery, chemotherapy, together with radiation were selected and entered into the nomogram model. The C-index of the model was significantly higher than TNM system in the training set (0.703 vs 0.572, P<0.001), which was also proved in the validation set (0.718 vs 0.588, P<0.001). The calibration curves for 1-, 2-, and 3-year OS probabilities exhibited good agreements between the nomogram-predicted and the actual observation. Decision curves displayed that the nomogram obtained more net benefits than TNM staging system in clinical context. The OS curves of two distinct risk groups stratified by nomogram-predicted survival outcome illustrated statistical difference. CONCLUSIONS We established and validated an easy-to-use prognostic nomogram, which can provide more accurate individualized prediction and assistance in decision making for pCCA patients.

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Consolidation or maintenance systemic therapy for newly diagnosed stage II, III, or IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma: a systematic review

Critical Reviews in Oncology/Hematology ◽

10.1016/j.critrevonc.2021.103336 ◽

2021 ◽

pp. 103336

Author(s):

Hal Hirte ◽

Xiaomei Yao ◽

Sarah E. Ferguson ◽

Taymaa May ◽

Laurie Elit

Keyword(s):

Systematic Review ◽

Fallopian Tube ◽

Systemic Therapy ◽

Stage Ii ◽

Newly Diagnosed ◽

Peritoneal Carcinoma ◽

Primary Peritoneal Carcinoma

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Primary peritoneal carcinoma in a young woman with suspected endometriosis

Fertility and Sterility ◽

10.1016/j.fertnstert.2009.02.005 ◽

2009 ◽

Vol 92 (1) ◽

pp. 390.e5-390.e7 ◽

Cited By ~ 1

Author(s):

Constanze Banz ◽

Sören von Otte ◽

Frank Noack ◽

Klaus Diedrich ◽

Daniela Hornung

Keyword(s):

Young Woman ◽

Peritoneal Carcinoma ◽

Primary Peritoneal Carcinoma

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Phase II Evaluation of Pemetrexed in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian or Primary Peritoneal Carcinoma: A Study of the Gynecologic Oncology Group

Yearbook of Oncology ◽

10.1016/s1040-1741(09)79452-7 ◽

2009 ◽

Vol 2009 ◽

pp. 43-44

Author(s):

J.T. Thigpen

Keyword(s):

Phase Ii ◽

Gynecologic Oncology ◽

Gynecologic Oncology Group ◽

Oncology Group ◽

Peritoneal Carcinoma ◽

Primary Peritoneal Carcinoma ◽

Platinum Resistant

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Intestinal lymphangiectasia mimicking primary peritoneal carcinoma

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2010.07.009 ◽

2010 ◽

Vol 203 (4) ◽

pp. e9-e11 ◽

Cited By ~ 2

Author(s):

Jennifer C. Steines ◽

Joshua H. Larson ◽

Neal Wilkinson ◽

Patricia Kirby ◽

Michael J. Goodheart

Keyword(s):

Intestinal Lymphangiectasia ◽

Peritoneal Carcinoma ◽

Primary Peritoneal Carcinoma

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