Meta‐analysis of heparin combined with aspirin versus aspirin alone for unexplained recurrent spontaneous abortion

2020 ◽  
Vol 151 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Jie Li ◽  
Yue‐hua Gao ◽  
Lin Xu ◽  
Zeng‐yan Li
Keyword(s):  
Spontaneous Abortion ◽  
Meta Analysis ◽  
Recurrent Spontaneous Abortion ◽  
Unexplained Recurrent Spontaneous Abortion

scholarly journals The Efficacy of Traditional Chinese Medicine Shoutai Pill Combined with Western Medicine in the First Trimester of Pregnancy in Women with Unexplained Recurrent Spontaneous Abortion: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Hui-fang Li ◽  
Qi-hong Shen ◽  
Xiao-qing Li ◽  
Zhang-feng Feng ◽  
Wei-min Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chinese Medicine ◽  
Spontaneous Abortion ◽  
Western Medicine ◽  
Meta Analysis ◽  
First Trimester ◽  
Recurrent Spontaneous Abortion ◽  
Unexplained Recurrent Spontaneous Abortion ◽  
First Trimester Of Pregnancy

Background. Shoutai Pill (STP), a famous classic herbal formula documented in traditional Chinese medicine (TCM), is widely available in China for treating unexplained recurrent spontaneous abortion (URSA). This systematic review and meta-analysis aims at evaluating the efficacy and safety of STP in the first trimester of pregnancy in women with a history of unexplained recurrent spontaneous abortion. Methods. The following eight databases were searched from their establishment to Dec 31, 2019, for randomized controlled trials (RCTs): PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), the Chinese BioMedical database (CBM), Chinese Scientific Journal Database (VIP), and the Wanfang database. The quality of evidence was estimated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results. A total of 12 studies (916 patients) with URSA were contained in this meta-analysis. The forest plot showed that patients treated with Shoutai Pill and western medicine had a significantly lower incidence of early pregnancy loss (RR: 0.42; 95% CI: 0.34–0.52; P<0.01, I2=0%). Subgroup analysis revealed that different types of TCM syndrome differentiation had the similar results. Also, in the combined group, patients had a lower TCM syndromes and symptoms and serum D-dimer level, while higher incidence of live birth. Conclusions. Our findings suggest that cotreatment with STP and western medicine might be superior to western medicine alone in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent spontaneous abortion, and there was no adverse event in the experimental group reported. However, the methodological quality of included RCTs was unsatisfactory; it is necessary to verify its effectiveness with further more standardized researches of rigorous design.

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