Chlamydia trachomatis infection among Ghanaian women undergoing hysterosalpingography for suspected tubal factor infertility

2019 ◽  
Vol 146 (2) ◽  
pp. 200-205
Author(s):  
Titus Beyuo ◽  
Samuel A. Oppong ◽  
Ali Samba ◽  
Vera M. Beyuo
Keyword(s):  
Chlamydia Trachomatis ◽  
Chlamydia Trachomatis Infection ◽  
Tubal Factor Infertility ◽  
Tubal Factor ◽  
Ghanaian Women

scholarly journals NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility

2015 ◽  
Vol 73 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Ivan Branković ◽  
Eleanne F. van Ess ◽  
Marlies P. Noz ◽  
Wilhelmina (Anke) J. Wiericx ◽  
Joke Spaargaren ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Functional Polymorphism ◽  
Chlamydia Trachomatis Infection ◽  
Tubal Factor Infertility ◽  
Tubal Factor

scholarly journals Relation between Chlamydia trachomatis infection and pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility in a Dutch cohort of women previously tested for chlamydia in a chlamydia screening trial

2019 ◽  
pp. sextrans-2018-053778 ◽  
Author(s):  
Bernice M Hoenderboom ◽  
Birgit H B van Benthem ◽  
Jan E A M van Bergen ◽  
Nicole H T M Dukers-Muijrers ◽  
Hannelore M Götz ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Control Strategies ◽  
Incidence Rates ◽  
Chlamydia Screening ◽  
Chlamydia Trachomatis Infection ◽  
Tubal Factor Infertility ◽  
Tubal Factor

ObjectivesA better understanding of Chlamydia trachomatis infection (chlamydia)–related sequelae can provide a framework for effective chlamydia control strategies. The objective of this study was to estimate risks and risk factors of pelvic inflammatory disease (PID), ectopic pregnancy and tubal factor infertility (TFI) with a follow-up time of up until 8 years in women previously tested for chlamydia in the Chlamydia Screening Implementation study (CSI) and participating in the Netherlands Chlamydia Cohort Study (NECCST).MethodsWomen who participated in the CSI 2008–2011 (n=13 498) were invited in 2015–2016 for NECCST. Chlamydia positive was defined as a positive CSI-PCR test, positive chlamydia serology and/or self-reported infection (time dependent). Data on PID, ectopic pregnancy and TFI were collected by self-completed questionnaires. Incidence rates and HRs were compared between chlamydia-positive and chlamydia-negative women corrected for confounders.ResultsOf 5704 women included, 29.5% (95% CI 28.3 to 30.7) were chlamydia positive. The incidence rate of PID was 1.8 per 1000 person-years (py) (1.6 to 2.2) overall, 4.4 per 1000 py (3.3 to 5.7) among chlamydia positives compared with 1.4 per 1000 py (1.1 to 1.7) for chlamydia negatives. For TFI, this was 0.4 per 1000 py (0.3 to 0.5) overall, 1.3 per 1000 py (0.8 to 2.1) and 0.2 per 1000 py (0.1 to 0.4) among chlamydia positives and negatives, respectively. And for ectopic pregnancy, this was 0.6 per 1000 py (0.5 to 0.8) overall, 0.8 per 1000 py (0.4 to 1.5) and 0.6 per 1000 py (0.4 to 0.8) for chlamydia negatives. Among chlamydia-positive women, the strongest risk factor for PID was symptomatic versus asymptomatic infection (adjusted HR 2.88, 1.4 to 4.5) and for TFI age <20 versus >24 years at first infection (HR 4.35, 1.1 to 16.8).ConclusionWe found a considerably higher risk for PID and TFI in chlamydia-positive women, but the incidence for ectopic pregnancy was comparable between chlamydia-positive and chlamydia-negative women. Overall, the incidence rates of sequelae remained low.Trial registrationNTR-5597.

scholarly journals MiR-378b Modulates Chlamydia-Induced Upper Genital Tract Pathology

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 566
Author(s):  
Stephanie R. Lundy ◽  
Kobe Abney ◽  
Debra Ellerson ◽  
Joseph U. Igietseme ◽  
Darin Carroll ◽  
...  
Keyword(s):  
Host Responses ◽  
Chlamydia Infection ◽  
Chlamydia Trachomatis Infection ◽  
Host Immune Responses ◽  
Tubal Factor Infertility ◽  
Evolutionarily Conserved ◽  
Duration Of Infection ◽  
Tubal Factor ◽  
Pathologic Lesions ◽  
Mammalian Gene Expression

Genital Chlamydia trachomatis infection causes severe reproductive pathologies such as salpingitis and pelvic inflammatory disease that can lead to tubal factor infertility. MicroRNAs (miRNAs) are evolutionarily conserved regulators of mammalian gene expression in development, immunity and pathophysiologic processes during inflammation and infection, including Chlamydia infection. Among the miRNAs involved in regulating host responses and pathologic outcome of Chlamydia infection, we have shown that miR-378b was significantly differentially expressed during primary infection and reinfection. In this study, we tested the hypothesis that miR-378b is involved in the pathological outcome of Chlamydia infection. We developed miR-378b knockout mice (miR-378b−/−) using Crispr/Cas and infected them along with their wild-type (WT) control with Chlamydia to compare the infectivity and reproductive pathologies. The results showed that miR-378b−/− mice were unable to clear the infection compared to WT mice; also, miR-378b−/− mice exhibited a relatively higher Chlamydia burden throughout the duration of infection. However, gross pathology results showed that miR-378b−/− mice had significantly reduced uterine dilatations and pathologic lesions after two infections compared to WT mice. In addition, the pregnancy and fertility rates for infected miR-378b−/− mice showed protection from Chlamydia-induced infertility with fertility rate that was comparable to uninfected WT mice. These results are intriguing as they suggest that miR-378b is important in regulating host immune responses that control Chlamydial replication and drive the inflammation that causes complications such as infertility. The finding has important implications for biomarkers of Chlamydial complications and targets for prevention of disease.

Microbiologic study of chronic inflammation associated with tubal factor infertility: role of Chlamydia trachomatis

1987 ◽  
Vol 47 (2) ◽  
pp. 274-277 ◽  
Author(s):  
Jeanine Henry-Suchet ◽  
Christine Utzmann ◽  
Jean De Brux ◽  
Pierre Ardoin ◽  
François Catalan
Keyword(s):  
Chlamydia Trachomatis ◽  
Chronic Inflammation ◽  
Tubal Factor Infertility ◽  
Tubal Factor

scholarly journals Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility

2020 ◽  
Vol 8 (6) ◽  
pp. 918 ◽  
Author(s):  
Wies T.M. van Dooremalen ◽  
Stephan P. Verweij ◽  
Janneke E. den Hartog ◽  
Carole Kebbi-Beghdadi ◽  
Sander Ouburg ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Intracellular Pathogen ◽  
Serum Samples ◽  
Tubal Factor Infertility ◽  
Fertility Clinic ◽  
Tubal Factor ◽  
Adverse Pregnancy

Waddlia chondrophila is an emerging intracellular pathogen belonging to the order of Chlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both W. chondrophila and Chlamydia trachomatis IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for C. trachomatis and 38.8% for W. chondrophila. C. trachomatis antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for W. chondrophila no difference could be observed. In conclusion, our study confirms the association between C. trachomatis seropositivity and TFI, but no association was found between W. chondrophila seropositivity and TFI. The high percentage of W. chondrophila seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this Chlamydia-like bacterium and its possible role in infertility.

scholarly journals Predicting tubal factor infertility by using markers of humoral and cell-mediated immune response against Chlamydia trachomatis

2018 ◽  
Vol 80 (5) ◽  
pp. e13051 ◽  
Author(s):  
Tiina Rantsi ◽  
Hanna Öhman ◽  
Mirja Puolakkainen ◽  
Aini Bloigu ◽  
Jorma Paavonen ◽  
...  
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Tubal Factor Infertility ◽  
Cell Mediated Immune Response ◽  
Tubal Factor
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