scholarly journals The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre‐eclampsia: A pragmatic guide for first‐trimester screening and prevention

2019 ◽  
Vol 145 (S1) ◽  
pp. 1-33 ◽  
Author(s):  
Liona C. Poon ◽  
Andrew Shennan ◽  
Jonathan A. Hyett ◽  
Anil Kapur ◽  
Eran Hadar ◽  
...  
Keyword(s):  
First Trimester ◽  
International Federation ◽  
First Trimester Screening ◽  
Gynecology And Obstetrics ◽  
Trimester Screening ◽  
Screening And Prevention

scholarly journals Predictive value of extreme low PAPP-A, free βhCG and extreme high mean uterine artery pulsatility index in the first trimester for fetal growth restriction

2020 ◽  
Vol 77 (3) ◽  
pp. 256-261
Author(s):  
Relja Lukic ◽  
Natasa-Orlic Karadzov ◽  
Amira Egic ◽  
Barbara Damnjanovic-Pazin ◽  
Zeljko Mikovic
Keyword(s):  
Pulsatility Index ◽  
First Trimester ◽  
Growth Restriction ◽  
Categorical Variables ◽  
Continuous Variables ◽  
First Trimester Screening ◽  
Gynecology And Obstetrics ◽  
Risk Pregnancy ◽  
Trimester Screening ◽  
Adverse Pregnancy

Background/Aim. Adverse pregnancy outcomes such as preeclampsia (PE), placental abruption (PA), fetal intrauterine growth restriction (IUGR) and stillbirth could be recognized by prenatal screening. The objective of this study was to predict IUGR by using first-trimester extremely low pregnancy-associated plasma protein-A (PAPP-A), extremely low free beta-human chorionic gonadotropin (free ?hCG) levels, and extremely high Pulsatility-index (PI) of uterine arteries, as single and combined predictors for IUGR development. Methods. This was a prospective first-trimester study analyzing singleton pregnancies at 11?13+6 weeks? gestation who underwent routine first-trimester screening at the Department of High Risk Pregnancy of the Clinic for Gynecology and Obstetrics ?Narodni front?, University of Belgrade, Serbia. First-trimester screening for PAPP-A, free ?hCG, and PI was performed in nulliparous, normotensive women with extremely low PAPP-A (PAPP-A ? 0.52 unit multiple of median ? MoM) and/or extremely low free ?hCG (free ?hCG ? 0.56 MoM) and/or extremely high PI (PI ? 2.52). Results. Of 85 pregnant women included in the final analysis, 14 (16.5%) developed IUGR. PAPP-A ? 0.52 MoM and PI ? 2.52, as single categorical variables, found to be with high predictable values for IUGR development (odds ratio ? OR = 3.064, 95% confidence interval ? CI= 0.634-14.810, p = 0.046, and OR = 2.129, 95% CI = 0.449?10.713, p = 0.021, respectively). Furthermore, the receiver operating characteristic (ROC curve identified PAPP-A and PI as continuous variables to be significant predictors of IUGR (area under curve ? AUC = 0.671, 95% CI = 0.521?0.820, p = 0.045, and AUC = 0.744, 95% CI = 0.587?0.902, p = 0.004, respectively). Conclusion. The present study suggests that the first trimester extremely low PAPP-A and increased Doppler-PI levels are single predictors of IUGR. Described model could be used in a routine daily clinical practice in resource limited settings where other parameters are not available for the prediction of IUGR development.

Trends in early prenatal screening for chromosomal abnormalities and congenital malformations in Russia in 2018

2020 ◽  
pp. 76-78
Author(s):  
Е.А. Калашникова ◽  
Е.Н. Андреева ◽  
П.А. Голошубов ◽  
Н.О. Одегова ◽  
Е.В. Юдина ◽  
...  
Keyword(s):  
Reference Values ◽  
Congenital Malformations ◽  
Prenatal Screening ◽  
Chromosomal Abnormalities ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Overall Effectiveness ◽  
Regions Of Russia

В ходе анализа результатов раннего пренатального скрининга (РПС) в России за 2018 г. (Аудит-2019) дана оценка качества мероприятий, общей эффективности и тенденций развития системы РПС в субъектах РФ посредством сравнения рассчитанных основных организационных, методологических и интегральных показателей с международными референтными значениями. In the course of analyzing the results of early prenatal combined first-trimester screening (FTS) in Russia for 2018 (Audit-2019) the assessment of the quality of measures, the overall effectiveness and trends in the development of the FTS system in the regions of Russia. They are presented by comparing the calculated main organizational, methodological and integral indicators with international reference values.

scholarly journals Two-stage first-trimester screening for trisomy 21 by ultrasound assessment and biochemical testing

2010 ◽  
Vol 36 (5) ◽  
pp. 542-547 ◽  
Author(s):  
K. O. Kagan ◽  
I. Staboulidou ◽  
J. Cruz ◽  
D. Wright ◽  
K. H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
First Trimester Screening ◽  
Two Stage ◽  
Trimester Screening ◽  
Ultrasound Assessment ◽  
Biochemical Testing

Sequential Pathways of Testing After First-Trimester Screening for Trisomy 21

2004 ◽  
Vol 104 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Lawrence D. Platt ◽  
Naomi Greene ◽  
Anthony Johnson ◽  
Julia Zachary ◽  
Elizabeth Thom ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening
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