Systematic review and meta-analysis of the performance of second-trimester screening for prenatal detection of congenital heart defects

2017 ◽  
Vol 140 (2) ◽  
pp. 137-145 ◽  
Author(s):  
Christine L. van Velzen ◽  
Johannes C.F. Ket ◽  
Peter M. van de Ven ◽  
Nico A. Blom ◽  
Monique C. Haak
Keyword(s):  
Systematic Review ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Meta Analysis ◽  
Second Trimester ◽  
Prenatal Detection ◽  
Second Trimester Screening ◽  
Trimester Screening

Second trimester cardiac diagnosis: screening standards and outcomes

2014 ◽  
Vol 24 (S2) ◽  
pp. 19-25 ◽  
Author(s):  
Sally-Ann B. Clur ◽  
Caterina M. Bilardo
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Low Risk ◽  
Second Trimester ◽  
Detection Rates ◽  
Targeted Interventions ◽  
Chamber View ◽  
Second Trimester Screening ◽  
Trimester Screening

AbstractSecond trimester screening for congenital heart defects occurs during the routine 18–20 weeks’ anomaly scan in many countries. Most congenital heart defects can be prenatally detected by experts in foetal echocardiography working in tertiary centres with high-risk pregnancies. Many studies, however, have shown that detection rates obtained by experts are not reproducible in the low-risk peripheral practices where most of the foetal screening takes place. As the majority of foetuses with congenital heart defects are born to mothers with no identifiable risk factors, it is important that widespread screening of the low-risk population occurs. To facilitate this, standard protocols have been introduced in several countries, but they are not universal and have differing sensitivities depending on the screening views advocated and the area studied. Initially, only performing the four-chamber view (basic scan) was advocated. By adding the outflow tract views (extended scan), three-vessel, and laterality views, the sensitivity of the examination can be significantly increased. Unfortunately, the sensitivity of these extended protocols still does not meet that obtainable in experienced hands, reflecting the additional skill required to obtain these extended views. Thus, close links are required between the tertiary centres and the screening centres to teach and maintain the skills required to obtain and interpret the required views, and to support the sonographer’s commitment. Furthermore, an audit system is required to trace false-positive and -negative cases so that targeted interventions can be planned. This is important, as a missed case of prenatal congenital heart defect is potentially a missed opportunity to reduce postnatal morbidity and mortality.

scholarly journals Children Born with Congenital Heart Defects and Growth Restriction at Birth: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (9) ◽  
pp. 3056 ◽  
Author(s):  
Ali Ghanchi ◽  
Neil Derridj ◽  
Damien Bonnet ◽  
Nathalie Bertille ◽  
Laurent J. Salomon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Congenital Heart Defects ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Congenital Heart ◽  
Heart Defects ◽  
Data Extraction ◽  
Meta Analysis ◽  
Adverse Outcomes ◽  
Growth Restriction

Newborns with congenital heart defects tend to have a higher risk of growth restriction, which can be an independent risk factor for adverse outcomes. To date, a systematic review of the relation between congenital heart defects (CHD) and growth restriction at birth, most commonly estimated by its imperfect proxy small for gestational age (SGA), has not been conducted. Objective: To conduct a systematic review and meta-analysis to estimate the proportion of children born with CHD that are small for gestational age (SGA). Methods: The search was carried out from inception until 31 March 2019 on Pubmed and Embase databases. Studies were screened and selected by two independent reviewers who used a predetermined data extraction form to obtain data from studies. Bias was assessed using the Critical Appraisal Skills Programme (CASP) checklist. The database search identified 1783 potentially relevant publications, of which 38 studies were found to be relevant to the study question. A total of 18 studies contained sufficient data for a meta-analysis, which was done using a random effects model. Results: The pooled proportion of SGA in all CHD was 20% (95% CI 16%–24%) and 14% (95% CI 13%–16%) for isolated CHD. Proportion of SGA varied across different CHD ranging from 30% (95% CI 24%–37%) for Tetralogy of Fallot to 12% (95% CI 7%–18%) for isolated atrial septal defect. The majority of studies included in the meta-analysis were population-based studies published after 2010. Conclusion: The overall proportion of SGA in all CHD was 2-fold higher whereas for isolated CHD, 1.4-fold higher than the expected proportion in the general population. Although few studies have looked at SGA for different subtypes of CHD, the observed variability of SGA by subtypes suggests that growth restriction at birth in CHD may be due to different pathophysiological mechanisms.

Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis

The Lancet ◽  
2012 ◽  
Vol 379 (9835) ◽  
pp. 2459-2464 ◽  
Author(s):  
Shakila Thangaratinam ◽  
Kiritrea Brown ◽  
Javier Zamora ◽  
Khalid S Khan ◽  
Andrew K Ewer
Keyword(s):  
Systematic Review ◽  
Pulse Oximetry ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Meta Analysis ◽  
Pulse Oximetry Screening

Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

2015 ◽  
Vol 35 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Ditte E. S. Jørgensen ◽  
Niels Vejlstrup ◽  
Connie Jørgensen ◽  
Lisa Leth Maroun ◽  
Jesper Steensberg ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Low Risk ◽  
Second Trimester ◽  
Risk Population ◽  
Prenatal Detection ◽  
Second Trimester Screening ◽  
Trimester Screening
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