Iminosugars as Immunomodulating Agents: Synthesis and Biological Activities of 1-Deoxynojirimycin and Related Compounds

2015 ◽  
Vol 55 (3-4) ◽  
pp. 336-346 ◽  
Author(s):  
Qin Li ◽  
Xin-Shan Ye
Keyword(s):  
Biological Activities ◽  
Related Compounds

Biotransformation of Coumarins by Filamentous Fungi: An Alternative Way for Achievement of Bioactive Analogs

2019 ◽  
Vol 16 (6) ◽  
pp. 568-577 ◽  
Author(s):  
Jainara Santos do Nascimento ◽  
João Carlos Silva Conceição ◽  
Eliane de Oliveira Silva
Keyword(s):  
Filamentous Fungi ◽  
Chemical Reactions ◽  
Biological Activities ◽  
Chemical Transformations ◽  
Chemical Structures ◽  
Pattern Structures ◽  
Pharmacological Interest ◽  
Aspergillus Sp ◽  
The Impact ◽  
Related Compounds

Coumarins are natural 1,2-benzopyrones, present in remarkable amounts as secondary metabolites in edible and medicinal plants. The low yield in the coumarins isolation from natural sources, along with the difficulties faced by the total synthesis, make them attractive for biotechnological studies. The current literature contains several reports on the biotransformation of coumarins by fungi, which can generate chemical analogs with high selectivity, using mild and eco-friendly conditions. Prompted by the enormous pharmacological interest in the coumarin-related compounds, their alimentary and chemical applications, this review covers the biotransformation of coumarins by filamentous fungi. The chemical structures of the analogs were presented and compared with those from the pattern structures. The main chemical reactions catalyzed the insertion of functional groups, and the impact on the biological activities caused by the chemical transformations were discussed. Several chemical reactions can be catalyzed by filamentous fungi in the coumarin scores, mainly lactone ring opening, C3-C4 reduction and hydroxylation. Chunninghamella sp. and Aspergillus sp. are the most common fungi used in these transformations. Concerning the substrates, the biotransformation of pyranocoumarins is a rarer process. Sometimes, the bioactivities were improved by the chemical modifications and coincidences with the mammalian metabolism were pointed out.

Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides

1983 ◽  
Vol 26 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Erik De Clercq ◽  
Johan Descamps ◽  
Jan Balzarini ◽  
Jerzy Giziewicz ◽  
Philip J. Barr ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Biological Activities ◽  
Related Compounds

Structural separation of biological activities of jasmonates and related compounds

1997 ◽  
pp. 3549-3560 ◽  
Author(s):  
Siegfried Blechert ◽  
Christian Bockelmann ◽  
Oliver Brümmer ◽  
Martin Füßlein ◽  
Heidrun Gundlach ◽  
...  
Keyword(s):  
Biological Activities ◽  
Related Compounds ◽  
Structural Separation

Synthesis of biologically active heterocyclic compounds from allenic and acetylenic nitriles and related compounds

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marthe Carine Djuidje Fotsing ◽  
Dieudonné Njamen ◽  
Zacharias Tanee Fomum ◽  
Derek Tantoh Ndinteh
Keyword(s):  
Michael Addition ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Polycyclic Compounds ◽  
One Step ◽  
Pharmaceutical Properties ◽  
Related Compounds ◽  
Acetylenic Acids ◽  
The Michael Addition

Abstract Cyclic and polycyclic compounds containing moieties such as imidazole, pyrazole, isoxazole, thiazoline, oxazine, indole, benzothiazole and benzoxazole benzimidazole are prized molecules because of the various pharmaceutical properties that they display. This led Prof. Landor and co-workers to engage in the synthesis of several of them such as alkylimidazolenes, oxazolines, thiazolines, pyrimidopyrimidines, pyridylpyrazoles, benzoxazines, quinolines, pyrimidobenzimidazoles and pyrimidobenzothiazolones. This review covers the synthesis of biologically active heterocyclic compounds by the Michael addition and the double Michael addition of various amines and diamines on allenic nitriles, acetylenic nitriles, hydroxyacetylenic nitriles, acetylenic acids and acetylenic aldehydes. The heterocycles were obtained in one step reaction and in most cases, did not give side products. A brief discussion on the biological activities of some heterocycles is also provided.

scholarly journals Studies on Antidiabetic Agents. X. Synthesis and Biological Activities of Pioglitazone and Related Compounds.

1991 ◽  
Vol 39 (6) ◽  
pp. 1440-1445 ◽  
Author(s):  
Yu MOMOSE ◽  
Kanji MEGURO ◽  
Hitoshi IKEDA ◽  
Chitoshi HATANAKA ◽  
Satoru OI ◽  
...  
Keyword(s):  
Biological Activities ◽  
Antidiabetic Agents ◽  
Related Compounds

Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary

2019 ◽  
Vol 30 ◽  
pp. 43-48 ◽  
Author(s):  
Yu Buchin ◽  
Yuka Sakemi ◽  
Ruriko Hamashima ◽  
Yuko Morioka ◽  
Daisuke Yamanaka ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Biological Activities ◽  
Carnosic Acid ◽  
Related Compounds

Synthesis and biological activities of degraded limonoids, (±)-fraxinellonone and its related compounds

1997 ◽  
Vol 38 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Hiroaki Okamura ◽  
Keiko Yamauchi ◽  
Keiji Miyawaki ◽  
Tetsuo Iwagawa ◽  
Munehiro Nakatani
Keyword(s):  
Biological Activities ◽  
Related Compounds
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