scholarly journals Use of Methionine Alkylation to Prepare Cationic and Zwitterionic Block Copolypeptide Vesicles

2015 ◽  
Vol 56 (8) ◽  
pp. 607-613 ◽  
Author(s):  
April R. Rodriguez ◽  
Uh-Joo Choe ◽  
Daniel T. Kamei ◽  
Timothy J. Deming
Keyword(s):  
Block Copolypeptide

scholarly journals Intracellular Fates of Cell-Penetrating Block Copolypeptide Vesicles

2011 ◽  
Vol 12 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Victor Z. Sun ◽  
Zhibo Li ◽  
Timothy J. Deming ◽  
Daniel T. Kamei
Keyword(s):  
Cell Penetrating ◽  
Block Copolypeptide

scholarly journals Block Copolypeptide Nanoparticles for the Delivery of Ocular Therapeutics

2014 ◽  
Vol 15 (1) ◽  
pp. 138-145 ◽  
Author(s):  
Timo Stukenkemper ◽  
Anica Dose ◽  
Maria Caballo Gonzalez ◽  
Alexander J.J. Groenen ◽  
Sarah Hehir ◽  
...  
Keyword(s):  
Block Copolypeptide

scholarly journals Endocytosis and Intracellular Trafficking Properties of Transferrin-Conjugated Block Copolypeptide Vesicles

2013 ◽  
Vol 14 (5) ◽  
pp. 1458-1464 ◽  
Author(s):  
Uh-Joo Choe ◽  
April R. Rodriguez ◽  
Brian S. Lee ◽  
Scott M. Knowles ◽  
Anna M. Wu ◽  
...  
Keyword(s):  
Intracellular Trafficking ◽  
Block Copolypeptide

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

Transfection of Mammalian Cells Using Block Copolypeptide Vesicles

2013 ◽  
Vol 13 (5) ◽  
pp. 539-550 ◽  
Author(s):  
Victor Z. Sun ◽  
Uh-Joo Choe ◽  
April R. Rodriguez ◽  
Howard Dai ◽  
Timothy J. Deming ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Block Copolypeptide

Biosilicification Templated by Amphiphilic Block Copolypeptide Assemblies

2010 ◽  
Vol 10 (12) ◽  
pp. 1566-1575 ◽  
Author(s):  
Lin Xia ◽  
Yu Liu ◽  
Zhibo Li
Keyword(s):  
Block Copolypeptide

scholarly journals Self-Sorting Microscale Compartmentalized Block Copolypeptide Hydrogels

2019 ◽  
Vol 8 (10) ◽  
pp. 1275-1279 ◽  
Author(s):  
Yintao Sun ◽  
Laurent A. Bentolila ◽  
Timothy J. Deming
Keyword(s):  
Block Copolypeptide

Efficient and stable enzyme immobilization in a block copolypeptide vesicle-templated biomimetic silica support

2010 ◽  
Vol 80 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Jun-Kun Lai ◽  
Tzu-Han Chuang ◽  
Jeng-Shiung Jan ◽  
Steven Sheng-Shih Wang
Keyword(s):  
Enzyme Immobilization ◽  
Silica Support ◽  
Block Copolypeptide

Metal Ion-Induced Self-Assembly of a Multi-Responsive Block Copolypeptide into Well-Defined Nanocapsules

Small ◽  
2016 ◽  
Vol 12 (18) ◽  
pp. 2476-2483 ◽  
Author(s):  
Mark B. van Eldijk ◽  
Lise Schoonen ◽  
Jeroen J. L. M. Cornelissen ◽  
Roeland J. M. Nolte ◽  
Jan C. M. van Hest
Keyword(s):  
Self Assembly ◽  
Metal Ion ◽  
Block Copolypeptide
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