Pre‐diagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

2021 ◽  
Author(s):  
Magdalena Stepien ◽  
Marina Lopez‐Nogueroles ◽  
Agustin Lahoz ◽  
Tilman Kühn ◽  
Gabriel Perlemuter ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bile Acid ◽  
Bile Acid Profiles

AMA-positives without PBC and healthy subjects have similar bile acid profiles but are different from PBC patients

2019 ◽  
Author(s):  
S Zandanell ◽  
A Feldman ◽  
M Strasser ◽  
J Tevini ◽  
T Felder ◽  
...  
Keyword(s):  
Bile Acid ◽  
Healthy Subjects ◽  
Bile Acid Profiles

Cholestatic drugs impair bile acid profiles and disposition in HepaRG cells

2016 ◽  
Vol 258 ◽  
pp. S55
Author(s):  
A. Sharanek ◽  
A. Burban ◽  
L. Humbert ◽  
D. Rainteau ◽  
A. Guillouzo
Keyword(s):  
Bile Acid ◽  
Heparg Cells ◽  
Bile Acid Profiles

scholarly journals Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms

2021 ◽  
Author(s):  
Robert S. Thompson ◽  
Michelle K Gaffney ◽  
Shelby Hopkins ◽  
Tel Kelley ◽  
Antonio Gonzalez ◽  
...  
Keyword(s):  
Bile Acid ◽  
Body Temperature ◽  
Core Body Temperature ◽  
Nrem Sleep ◽  
Diurnal Rhythms ◽  
Shotgun Metagenomics ◽  
Relative Abundances ◽  
Negative Impacts ◽  
Bile Acid Profiles ◽  
Core Body

Chronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment of physiological systems, which in turn is associated with increased disease risk. Exposure to repeated or severe stressors also disturbs sleep and diurnal rhythms. Prebiotic nutrients produce favorable changes in gut microbial ecology, the gut metabolome, and reduce several negative impacts of acute severe stressor exposure, including disturbed sleep, core body temperature rhythmicity, and gut microbial dysbiosis. This study tested the hypothesis whether prebiotics can also reduce the negative impacts of CDR by facilitating light/dark realignment of sleep/wake, core body temperature, and locomotor activity; and whether prebiotic-induced changes in bacteria and bile acid profiles are associated with these effects. Male, Sprague Dawley rats were fed diets enriched in prebiotic substrates or calorically matched control chow. After 5 weeks on diet, rats were exposed to CDR (12h light/dark reversal, weekly for 8 weeks) or remained on undisturbed normal light/dark cycles (NLD). Sleep EEG, core body temperature, and locomotor activity were recorded via biotelemetry in freely moving rats. Fecal samples were collected on experimental days -33, 0 (day of onset of CDR), and 42. Taxonomic identification and relative abundances of gut microbes were measured in fecal samples using 16S rRNA gene sequencing and shotgun metagenomics. Fecal primary, bacterially-modified secondary, and conjugated bile acids were measured using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Prebiotic diet produced rapid and stable increases in the relative abundances of Parabacteroides distasonis and Ruminiclostridium 5. Shotgun metagenomics analyses confirmed reliable increases in relative abundances of Parabacteroides distasonis and Clostridium leptum, a member of the Ruminiclostridium genus. Prebiotic diet also modified fecal bile acid profiles; and based on correlational and step-wise regression analyses, Parabacteroides distasonis and Ruminiclostridium 5 were positively associated with each other and negatively associated with secondary and conjugated bile acids. Prebiotic diet, but not CDR, impacted beta diversity. Measures of alpha diversity evenness were decreased by CDR and prebiotic diet prevented that effect. Rats exposed to CDR while eating prebiotic, compared to control diet, more quickly realigned NREM sleep and core body temperature (ClockLab) diurnal rhythms to the altered light/dark cycle. Finally, both cholic acid and Ruminiclostridium 5 prior to CDR were associated with time to realign CBT rhythms to the new light/dark cycle after CDR; whereas both Ruminiclostridium 5 and taurocholic acid prior to CDR were associated with NREM sleep recovery after CDR. These results suggest that ingestion of prebiotic substrates is an effective strategy to increase the relative abundance of health promoting microbes, alter the fecal bile acid profile, and facilitate the recovery and realignment of sleep and diurnal rhythms after circadian disruption.

Potential Implications for Monitoring Serum Bile Acid Profiles in Circulation with Serum Proteome for Carbon Tetrachloride-Induced Liver Injury/Regeneration Model in Mice

2010 ◽  
Vol 9 (9) ◽  
pp. 4490-4500 ◽  
Author(s):  
Takashi Shimada ◽  
Tsuyoshi Nakanishi ◽  
Atsuhiko Toyama ◽  
Satoshi Yamauchi ◽  
Atsuhiro Kanzaki ◽  
...  
Keyword(s):  
Bile Acid ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Serum Bile Acid ◽  
Serum Proteome ◽  
Bile Acid Profiles

scholarly journals Molecular Genetic and Bile Acid Profiles in Two Japanese Patients With 3β-Hydroxy-Δ5-C27-Steroid Dehydrogenase/Isomerase Deficiency

2010 ◽  
Vol 68 (3) ◽  
pp. 258-263 ◽  
Author(s):  
Tatsuki Mizuochi ◽  
Akihiko Kimura ◽  
Isao Ueki ◽  
Tomoyuki Takahashi ◽  
Takuji Hashimoto ◽  
...  
Keyword(s):  
Bile Acid ◽  
Molecular Genetic ◽  
Japanese Patients ◽  
Bile Acid Profiles ◽  
Steroid Dehydrogenase

scholarly journals Genetic determinants of gut microbiota composition and bile acid profiles in mice

PLoS Genetics ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. e1008073 ◽  
Author(s):  
Julia H. Kemis ◽  
Vanessa Linke ◽  
Kelsey L. Barrett ◽  
Frederick J. Boehm ◽  
Lindsay L. Traeger ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Microbiota Composition ◽  
Genetic Determinants ◽  
Bile Acid Profiles ◽  
Gut Microbiota Composition

scholarly journals Assessment of serum bile acid profiles as biomarkers of liver injury and liver disease in humans

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193824 ◽  
Author(s):  
Lina Luo ◽  
Jiri Aubrecht ◽  
Dingzhou Li ◽  
Roscoe L. Warner ◽  
Kent J. Johnson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bile Acid ◽  
Liver Injury ◽  
Serum Bile Acid ◽  
Bile Acid Profiles
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